Results 71 to 80 of about 6,872 (199)
Impaired Alertness Correlates With Chronic Anxiety: A Prospective Tertiary University Centre Cohort
Journal of Sleep Research, EarlyView.ABSTRACT The Maintenance of Wakefulness Test (MWT) is a widely used objective measure of daytime alertness, especially in patients with sleep disorders at increased risk of accidents. Anxiety and depression are common in this population and may influence subjective sleepiness and objective alertness.
Anice Borjon +13 more
wiley +1 more source
Journal of Sleep Research, EarlyView.Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein +10 more
wiley +1 more source
Comparison of Actigraphy and Polysomnography in a Sleep Centre Cohort
Journal of Sleep Research, EarlyView.MotionWatch 8 actigraphy correlated most strongly with PSG for total sleep time and showed modest group‐level bias, but wide individual limits of agreement precluded interchangeability. PLMS modified actigraphy‐PSG differences, while recording setting influenced actigraphy‐derived sleep continuity across home and inpatient recordings.
Panagis Drakatos +8 more
wiley +1 more source
Actigraphy provides an objective measure of sleepiness and is recommended by the American Academy of Sleep Medicine for use 7–14 days prior to multiple sleep latency testing. It plays a valuable role in the differential diagnosis of hypersomnolence.
Maia, Susana +4 more
core +1 more source
International Forum of Allergy &Rhinology, Volume 16, Issue 9, Page 913-923, September 2026.ABSTRACT Background To determine the safety and efficacy of laser ablation of the posterior nasal nerve (PNN) for the treatment of chronic rhinitis. Methods This study was a single‐center, prospective, single‐blinded, randomized sham‐controlled trial. Patients with a 24‐h reflective Total Nasal Symptom Score (rTNSS) ≧ 5, rhinorrhea ≧ 2, and congestion ≧
Jyun‐Yi Liao +9 more
wiley +1 more source
Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia.
, 2013 OBJECTIVE: Clinical and immunological evaluation of 'incomplete' Bickerstaff brainstem encephalitis (BBE). METHODS: We studied two patients with postinfectious brainstem syndromes who presented at National University Hospital Singapore.
Wakerley, BR +4 more
core +1 more source
Clocks & SleepHypersomnia may be classified as primary or secondary, with secondary hypersomnia arising from a variety of underlying causes. Thus, according to ICSD3-TR classification, the diagnosis of idiopathic hypersomnia (IH) is established based on (1) excessive ...
Vlad Bucurescu +3 more
doaj +1 more source
FXTAS and the Spectrum of FMR1 Premutation‐Associated Phenotypes in Latin America: A Scoping Review
Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2045-2058, September 2026.Abstract Background Fragile X–associated tremor/ataxia syndrome (FXTAS) is a late‐onset neurodegenerative disorder caused by FMR1 premutation expansions (55–200 CGG repeats). Although well described in populations of predominantly European ancestry, FXTAS remains poorly characterized in Latin America due to limited awareness, restricted access to ...
Amy Schmidmajer +6 more
wiley +1 more source
Clinical Variability and Genotype‐Driven Outcomes in CHRND‐Related Congenital Myasthenic Syndrome
European Journal of Neurology, Volume 33, Issue 9, September 2026.Clinical variability in CHRND‐related congenital myasthenic syndrome ranges from isolated ocular involvement to severe neonatal‐onset disease with respiratory insufficiency. In a multicenter cohort of nine patients, ocular symptoms represented the core phenotype, while disease severity was influenced by genotype and presumed residual acetylcholine ...
David Muhmann +16 more
wiley +1 more source
Cerebrospinal fluid monoamine levels in central disorders of hypersomnolence
, 2021 International audienceAbstract Study Objectives Whether the cause of daytime sleepiness in narcolepsy type 1 (NT1) is a direct consequence of the loss of orexin (ORX) neurons or whether low orexin reduces the efficacy of the monoaminergic systems to ...
Dauvilliers, Yves +5 more
core +1 more source