Results 111 to 120 of about 2,219,611 (304)

Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model

European Respiratory Journal, 2017
The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH).
M. Hoeper, T. Kramer, Z. Pan, C. Eichstaedt, J. Spiesshoefer, N. Benjamin, K. Olsson, K. Meyer, C. Vizza, A. Vonk-Noordegraaf, O. Distler, C. Opitz, J. Gibbs, M. Delcroix, H. Ghofrani, D. Huscher, D. Pittrow, S. Rosenkranz, E. Grünig   +18 more
semanticscholar   +1 more source

Targeted Degradation of sGRP78 Alleviates the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
Soluble GRP78 (sGRP78) is identified as a novel tumor‐derived soluble factor that induces regulatory T cells (Treg). sGRP78 serves as an excellent serological biomarker for predicting the efficacy of neoadjuvant therapy in breast cancer patients. sGRP78 specifically binds to B cells, inducing the expression of IL‐10 and PD‐L1, thereby promoting Treg ...
Zhenghao Wu, Peng Zheng, Yunxiao Xiao, Qianheng Wang, Xin Pan, Xiaoqi Zhou, Yibing Lv, Junyi Xiao, Yong He, Tao Huang, Ping Lei   +10 more
wiley   +1 more source

Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension

European Respiratory Journal, 2017
Current European guidelines recommend periodic risk assessment for patients with pulmonary arterial hypertension (PAH). The aim of our study was to determine the association between the number of low-risk criteria achieved within 1 year of diagnosis and ...
A. Boucly, J. Weatherald, L. Savale, X. Jaïs, V. Cottin, G. Prévôt, F. Picard, P. De Groote, M. Jevnikar, E. Bergot, A. Chaouat, C. Chabanne, A. Bourdin, F. Parent, D. Montani, G. Simonneau, M. Humbert, O. Sitbon   +17 more
semanticscholar   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Nature Communications, 2018
Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious variation within components of the transforming growth factor-β pathway, particularly the bone morphogenetic protein type 2 receptor (BMPR2), underlies most ...
S. Gräf, M. Haimel, M. Bleda, C. Hadinnapola, L. Southgate, L. Southgate, Wei Li, J. Hodgson, Bin Liu, R. Salmon, M. Southwood, R. Machado, Jennifer M. Martin, C. Treacy, C. Treacy, Katherine Yates, L. Daugherty, O. Shamardina, Deborah Whitehorn, Simon Holden, M. Aldred, H. Bogaard, Colin Church, G. Coghlan, R. Condliffe, P. Corris, C. Danesino, M. Eyries, Henning Gall, Stefano Ghio, H. Ghofrani, H. Ghofrani, J. S. R. Gibbs, B. Girerd, A. Houweling, Luke Howard, Marc Humbert, D. Kiely, Gabor Kovacs, R. Ross, S. Moledina, D. Montani, M. Newnham, Andrea Olschewski, H. Olschewski, A. Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J. Rhodes, L. Scelsi, Werner Seeger, F. Soubrier, D. Stein, J. Suntharalingam, E. Swietlik, M. Toshner, D. A. Heel, A. Noordegraaf, Q. Waisfisz, J. Wharton, S. J. Wort, W. Ouwehand, Nicole Soranzo, Nicole Soranzo, A. Lawrie, P. Upton, Martin R. Wilkins, R. Trembath, N. Morrell   +68 more
semanticscholar   +1 more source

NO‐Driven Janus Nanomotor Enhances T‐Cell Infiltration by Reconstructing Tumor‐Associated Blood and Lymphatic Vessels

Advanced Science, EarlyView.
NO‐driven hollow gold Janus nanomotors (HAM) are engineered to improve tumor blood vessel normalization throughout the entire tumor region to enhance T‐cell intratumoral infiltration, and generate and capture whole‐tumor antigens as an in situ cancer vaccine to enhance T‐cell activation, therefore enhancing the antitumor immune response.
Qingping Ma, Shunli Fu, Yiming Xia, Shuying Gao, Zhenxing Xia, Panpan Gu, Shijun Yuan, Jinhu Liu, Shuang Liang, Nan Li, Qinglin Yang, Weiwei Mu, Jie Liu, Xinrui Liu, Yongjun Liu, Na Zhang   +15 more
wiley   +1 more source

Guidelines for the Treatment of Pulmonary Hypertension (JCS 2017/JPCPHS 2017).

Circulation Journal, 2019
J-STAGE Advance Publication released online March 9, 2019 Mailing address: Scientific Committee of the Japanese Circulation Society, 18F Imperial Hotel Tower, 1-1-1 Uchisaiwai-cho, Chiyoda-ku, Tokyo 100-0011, Japan.
K. Fukuda, H. Date, Shozaburo Doi, Y. Fukumoto, N. Fukushima, M. Hatano, Hiroshi Ito, M. Kuwana, H. Matsubara, S. Momomura, M. Nishimura, H. Ogino, T. Satoh, H. Shimokawa, K. Yamauchi-Takihara, K. Tatsumi, H. Ishibashi-Ueda, N. Yamada, S. Yoshida, K. Abe, A. Ogawa, T. Ogo, T. Kasai, M. Kataoka, Takashi Kawakami, S. Kogaki, Mashio Nakamura, T. Nakayama, M. Nishizaki, K. Sugimura, N. Tanabe, I. Tsujino, A. Yao, T. Akasaka, M. Ando, Takeshi Kimura, T. Kuriyama, N. Nakanishi, T. Nakanishi, H. Tsutsui   +39 more
semanticscholar   +1 more source

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

Advanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang, Di Mu, Su Liu, Peng‐Bo Jing, Bin Wu, Xiao‐Mei Yang, Jia‐Yi Ge, Qing‐Yi Li, Hao‐Hao Chen, Feng‐Ming Zhang, Bing Wang, Ying‐Ying Zhang, Linnan Qian, Zi‐Yi Zhu, Yu‐Sen Ou, Shi‐Yu Sun, Lin Luo, Yu Feng, Changyu Jiang, Zhuo Sun, Yong Chen, Hai‐Li Pan, Bin Wang, Fen‐Fei Gao, Jie Wu, Zhigang Lu, Tong Liu, Yan‐Gang Sun, Xing‐Jun Liu   +28 more
wiley   +1 more source

Unexplained breathlessness: Integrating pathophysiological insights with clinical evaluation

Clinical Medicine
Unexplained breathlessness is a challenging symptom encountered across diverse medical conditions. This review will briefly overview the interplay between central neural mechanisms and peripheral receptor activity leading to symptom perception.
Andrea Baccelli, Francesco Lo Giudice, Gulammehdi Haji, Rachel J. Davies, Wendy Gin-Sing, Luke S. Howard   +5 more
doaj   +1 more source

Echocardiographic assessment of pulmonary hypertension: a guideline protocol from the British Society of Echocardiography

Echo Research and Practice, 2018
Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg as confirmed on right heart catheterisation. Traditionally, the pulmonary arterial systolic pressure has been estimated on echo by utilising the simplified Bernoulli equation from ...
D. Augustine, Lindsay D Coates-Bradshaw, J. Willis, A. Harkness, L. Ring, J. Grapsa, G. Coghlan, Nikki Kaye, D. Oxborough, Shaun Robinson, J. Sandoval, B. Rana, A. Siva, P. Nihoyannopoulos, L. Howard, K. Fox, S. Bhattacharyya, V. Sharma, R. Steeds, T. Mathew   +19 more
semanticscholar   +1 more source