Results 131 to 140 of about 1,434,677 (298)

Pulmonary vascular disease, environmental pollution, and climate change

Pulmonary Circulation
Pollution and climate change constitute a combined, grave and pervasive threat to humans and to the life‐support systems on which they depend. Evidence shows a strong association between pollution and climate change on cardiovascular and respiratory ...
Mona Lichtblau, Lena Reimann, Lucilla Piccari   +2 more
doaj   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies

Cell Reports Medicine
Summary: Despite advances in treatment, the prognosis for patients with pulmonary arterial hypertension (PAH) remains dismal, highlighting the need for further therapeutic advances. By using RNA sequencing on pulmonary artery smooth muscle cells (PASMCs),
Sarah-Eve Lemay, Manon Mougin, Mélanie Sauvaget, Reem El Kabbout, Chanil Valasarajan, Keiko Yamamoto, Sandra Martineau, Andréanne Pelletier, Coralie Bilodeau, Yann Grobs, Alice Bourgeois, Charlotte Romanet, Sandra Breuils-Bonnet, Monica S. Montesinos, Min Lu, Huidong Chen, Mégan Gilbert, Charlie Théberge, François Potus, Soni Pullamsetti, Steeve Provencher, Sébastien Bonnet, Olivier Boucherat   +22 more
doaj   +1 more source

Arterial pulmonary hypertension in noncardiac intensive care unit

, 2008
Mykola V Tsapenko1,5, Arseniy V Tsapenko2, Thomas BO Comfere3,5, Girish K Mour1,5, Sunil V Mankad4, Ognjen Gajic1,51Division of Pulmonary and Critical Care Medicine; 3Division of Critical Care Medicine; 4Division of Cardiovascular Diseases, Mayo ...
Thomas BO Comfere, Ognjen Gajic, Girish K Mour, Arseniy V Tsapenko, Sunil V Mankad, Mykola V Tsapenko   +5 more
core  

Pulmonary Hypertension Associated with Interstitial Lung Disease: A Review on Diagnosis and Treatment with a Focus on Emerging Therapies

Pulmonary hypertension (PH) complicating interstitial lung diseases (ILDs) is critical for symptom burden and prognosis. The prevalence of PH varies according to ILD subgroups and severities. Establishing the diagnosis of PH associated with ILDs (PH-ILDs)
Wacker, J., Darie, A.M., Ulrich, S., Beghetti, M., Genecand, L., Lador, F., Guerreiro, I., Lechartier, B., Pohle, S., Lichtblau, M., Guler, S.A., Ulrich, Silvia, Beghetti, Maurice, Wacker Bou Puigdefabregas, Julie Caroline, Guler, Sabina A., Guler, Sabina A, Pohle, Susanne, Wacker, Julie; https://orcid.org/, Lechartier, Benoit, Lichtblau, Mona; https://orcid.org/, Lichtblau, Mona, Darie, Andrei M, Lador, Frédéric, Beghetti, Maurice; https://orcid.org/, Guerreiro, Ivan, Wacker, Julie, Lador, Frédéric; https://orcid.org/, Ulrich, Silvia; https://orcid.org/, Swiss Society of Pulmonary Hypertension, Genecand, Léon; https://orcid.org/, Lechartier, Benoit; https://orcid.org/, Guerreiro, Ivan; https://orcid.org/, Genecand, Léon   +32 more
core   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Ischemia-reperfusion injury with a model of porcine whole-blood ex-vivo lung perfusion

Frontiers in Transplantation
IntroductionOur objective was to model Ischemia-Reperfusion (IR) injuries by ex-vivo perfusion of porcine lungs with whole blood containing the inflammatory cells.MethodsLungs and whole blood were collected from 12 pigs and submitted to cold ischemia ...
Jean-Baptiste Menager, Jean-Baptiste Menager, Jean-Baptiste Menager, Julia Mercier, Julia Mercier, Justin Issard, Justin Issard, Justin Issard, Maria-Rosa Ghigna, Maria-Rosa Ghigna, Maria-Rosa Ghigna, Jeanne Tran Van Nhieu, Benoit Decante, Benoit Decante, Julien Guihaire, Julien Guihaire, Elie Fadel, Elie Fadel, Elie Fadel, Fabrice Antigny, Fabrice Antigny, Olaf Mercier, Olaf Mercier, Olaf Mercier   +23 more
doaj   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source

Pulmonary hypertension: diagnostic and therapeutic challenges

, 2015
Isabel S Bazan, Wassim H Fares Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, USA Abstract: Pulmonary hypertension (PH) is a hemodynamic and pathophysiologic state that can be ...
Bazan IS, Fares WH
core  

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source