Results 111 to 120 of about 1,353,360 (263)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Diuretic adherence in patients with pre-capillary pulmonary hypertension: insights from the PHARE study

ERJ Open Research
Background Supportive treatments, such as diuretics, play a critical role in managing pulmonary hypertension (PH). While low adherence to oral PH therapies worsens outcomes, the impact of diuretic adherence is less clear.
Antoine Le Bozec, Samuel D. Cohen, David Montani, Athénaïs Boucly, Christophe Guignabert, Anne Roche, Salma Al Kahf, Antoine Beurnier, Olivier Sitbon, Xavier Jaïs, Mitja Jevnikar, Marc Humbert, Laurent Savale, Marie-Camille Chaumais   +13 more
doaj   +1 more source

Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients

, 2018
Abbreviated versions of the risk stratification strategy of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension guidelines have been recently validated in patients with pulmonary arterial hypertension.
Grünig, Ekkehard, Olsson, Karen M., Gruenig, Ekkehard, Staehler, Gerd, Opitz, Christian F., Vonk-Noordegraaf, Anton, Pepke-Zaba, Joanna, Halank, Michael, Klose, Hans, Pittrow, David, Hoeper, Marius M., Gibbs, J. Simon R., Delcroix, Marion, Held, Matthias, Gall, Henning, Rosenkranz, Stephan, Tsangaris, Iraklis, Huscher, Doerte, Lange, Tobias J.   +18 more
core   +1 more source

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

American Journal of Hematology, EarlyView.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas, Nichola Cooper, Vickie McDonald, Karina Yazdanbakhsh, Wilma Barcellini   +4 more
wiley   +1 more source

Is pulmonary arterial hypertension associated with interferon-β therapy for multiple sclerosis reversible? A case study to explore the complexity

ERJ Open Research, 2020
Anastasia Anthi, Eleni Stagaki, Loukianos Rallidis, Dimitrios Konstantonis, Maria-Eleftheria Evangelopoulos, Konstantinos Voumvourakis, Apostolos Armaganidis, Stylianos E. Orfanos   +7 more
doaj   +1 more source

Unexplained breathlessness: Integrating pathophysiological insights with clinical evaluation

Clinical Medicine
Unexplained breathlessness is a challenging symptom encountered across diverse medical conditions. This review will briefly overview the interplay between central neural mechanisms and peripheral receptor activity leading to symptom perception.
Andrea Baccelli, Francesco Lo Giudice, Gulammehdi Haji, Rachel J. Davies, Wendy Gin-Sing, Luke S. Howard   +5 more
doaj   +1 more source

Current Management of pulmonary Hypertension

, 2018
treatment of pulmonary hypertension. New methods of the new drugs.
Jezawi, Abdullah
core  

Effects of combined angiotensin II receptor antagonism and neprilysin inhibition in experimental pulmonary hypertension and right ventricular failure

, 2019
Background: Combined angiotensin II receptor antagonism and neprilysin inhibition by LCZ696 reduces morbidity and mortality in heart failure patients and works by reducing RAAS activity and increasing cGMP levels.
Nyengaard, Jens Randel, de Man, Frances S., Axelsen, Julie Birkmose, Bogaard, Harm Jan, Ringgaard, Steffen, Nielsen-Kudsk, Jens Erik, Hyldebrandt, Janus Adler, Andersen, A., Andersen, S.   +8 more
core   +1 more source

Characteristics Associated With Persistent Long COVID Symptoms in Healthcare Personnel Infected With SARS‐CoV‐2 Between August 2022 and May 2024: A Multicenter Cohort Analysis of US Healthcare Personnel

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Long COVID affects a significant proportion of COVID‐19 survivors. This study examined persistent Long COVID symptoms among healthcare personnel (HCP) and evaluated associations with vaccination, prior SARS‐CoV‐2 infection, underlying health conditions, and demographics.
Eric Kontowicz, Amanda K. Irish, Lilly C. Lee, Howard A. Smithline, Ian D. Plumb, Melissa Briggs‐Hagen, Alexandra F. Rollins, Karisa K. Harland, Anusha Krishnadasan, Karin F. Hoth, Eliezer Santos‐León, David A. Talan, Nicholas M. Mohr, Project PREVENT Network   +13 more
wiley   +1 more source

A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Multiple mitochondrial dysfunctions syndrome 1 (MMDS1, MIM #605711) due to NFU1 gene defects is an ultra‐rare autosomal recessive inborn error of metabolism associated with reduced function of NFU1 iron–sulfur cluster (ISC) scaffold protein.
Charles R. DiFalco, Aaron Williams, Claudia Soler‐Alfonso, Emily Waskow, Elizabeth Mizerik, Fernando Scaglia, Chaya N. Murali   +6 more
wiley   +1 more source