Results 151 to 160 of about 2,500,398 (351)

Diagnosis of pulmonary hypertension

European Respiratory Journal, 2019
A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or ...
A. Frost, D. Badesch, J. Gibbs, D. Gopalan, D. Khanna, A. Manes, R. Oudiz, T. Satoh, F. Torres, A. Torbicki   +9 more
semanticscholar   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

What role does the right side of the heart play in circulation? [PDF]

, 2006
Right ventricular failure (RVF) is an underestimated problem in intensive care. This review explores the physiology and pathophysiology of right ventricular function and the pulmonary circulation.
Cecconi, M, Johnston, E, Rhodes, A
core   +2 more sources

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Patient engagement and self-management in pulmonary arterial hypertension

European Respiratory Review, 2016
Improved care in pulmonary arterial hypertension has led to increased longevity for patients, with a paralleled evolution in the nature of their needs.
Jytte Graarup, Pisana Ferrari, Luke S. Howard   +2 more
doaj   +1 more source

Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model

European Respiratory Journal, 2017
The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH).
M. Hoeper, T. Kramer, Z. Pan, C. Eichstaedt, J. Spiesshoefer, N. Benjamin, K. Olsson, K. Meyer, C. Vizza, A. Vonk-Noordegraaf, O. Distler, C. Opitz, J. Gibbs, M. Delcroix, H. Ghofrani, D. Huscher, D. Pittrow, S. Rosenkranz, E. Grünig   +18 more
semanticscholar   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension

European Respiratory Journal, 2017
Current European guidelines recommend periodic risk assessment for patients with pulmonary arterial hypertension (PAH). The aim of our study was to determine the association between the number of low-risk criteria achieved within 1 year of diagnosis and ...
A. Boucly, J. Weatherald, L. Savale, X. Jaïs, V. Cottin, G. Prévôt, F. Picard, P. De Groote, M. Jevnikar, E. Bergot, A. Chaouat, C. Chabanne, A. Bourdin, F. Parent, D. Montani, G. Simonneau, M. Humbert, O. Sitbon   +17 more
semanticscholar   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Guidelines for the Treatment of Pulmonary Hypertension (JCS 2017/JPCPHS 2017).

Circulation Journal, 2019
J-STAGE Advance Publication released online March 9, 2019 Mailing address: Scientific Committee of the Japanese Circulation Society, 18F Imperial Hotel Tower, 1-1-1 Uchisaiwai-cho, Chiyoda-ku, Tokyo 100-0011, Japan.
K. Fukuda, H. Date, Shozaburo Doi, Y. Fukumoto, N. Fukushima, M. Hatano, Hiroshi Ito, M. Kuwana, H. Matsubara, S. Momomura, M. Nishimura, H. Ogino, T. Satoh, H. Shimokawa, K. Yamauchi-Takihara, K. Tatsumi, H. Ishibashi-Ueda, N. Yamada, S. Yoshida, K. Abe, A. Ogawa, T. Ogo, T. Kasai, M. Kataoka, Takashi Kawakami, S. Kogaki, Mashio Nakamura, T. Nakayama, M. Nishizaki, K. Sugimura, N. Tanabe, I. Tsujino, A. Yao, T. Akasaka, M. Ando, Takeshi Kimura, T. Kuriyama, N. Nakanishi, T. Nakanishi, H. Tsutsui   +39 more
semanticscholar   +1 more source