Results 71 to 80 of about 1,957,875 (298)

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice

Diabetology & Metabolic Syndrome
Background Roux-en-Y gastric bypass (RYGB) surgery is an effective metabolic surgery against diabetes and obesity. Clinical evidence indicates that patients with severe obesity have a poor curative effect in losing weight if they suffer from leptin or ...
Dan Tong, Jie Xiang, Wei Liu, Fang Sun, Lijuan Wang, Aidi Mou, Tingbing Cao, Qing Zhou, Mei You, Yingying Liao, Peng Gao, Daoyan Liu, Zongshi Lu, Zhiming Zhu   +13 more
doaj   +1 more source

Right ventricular hypertrophy in systemic hypertension: An updated review of clinical studies

, 2013
AIM: Experimental and clinical evidence supports the view that right ventricular hypertrophy (RVH) may parallel left ventricular hypertrophy in systemic hypertension; a comprehensive analysis of this issue, however, is lacking.
C. Cuspidi, C. Sala, Cuspidi, Cesare, MUIESAN, Maria Lorenza, M. L. Muiesan, G. Schillaci, Sala, Carla, De Luca, Nicola, Schillaci, Giuseppe, N. De Luca, Sala C, Working Group on Heart Hypertension of the Italian Society of Hypertension, Cuspidi C, Muiesan ML, Schillaci G   +14 more
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

The body mass index-glucose index as a new tool for early detection of the risk of dysglycemia in patients with hypertension and obstructive sleep apnea

BMC Endocrine Disorders
Purpose Currently, there is a lack of early biomarkers to identify the risk of dysglycemia in patients with concurrent hypertension and obstructive sleep apnea (OSA).
Wenbo Yang, Xintian Cai, Mulalibieke Heizhati, Qing Zhu, Xiaoguang Yao, Wen Wen, Di Shen, Junli Hu, Jing Hong, Nanfang Li   +9 more
doaj   +1 more source

Lifestyle modification and hypertension prevention [PDF]

BACKGROUND: Hypertension, a clear risk factor for cardiovascular diseases, affects nearly one billion people worldwide. Recent statistics have reported increasing mortality due to hypertension which reveals the importance of prophylactic strategies in ...
قربانی, اعظم, قزلباش, سيما   +1 more
core  

Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. [PDF]

, 2014
Resistant hypertension continues to pose a major challenge to clinicians worldwide and has serious implications for patients who are at increased risk of cardiovascular morbidity and mortality with this diagnosis.
Matson, M, Williams, B, Paton, JF, Kapil, Vikas, Moss, J, Simpson, Iain, Knight, Charles, Poulter, Neil, Poulter, N, Collier, David, de Belder, Mark A, Caulfield, Mark J, Matson, Matthew, Simpson, I, Cleveland, Trevor, Deanfield, John, Lobo, MD, de Belder, MA, Williams, Bryan, Lobo, Melvin D, Moss, Jonathan, Caulfield, MJ, Kapil, V, Knight, C, Paton, Julian F R, Dasgupta, I, Paton, JFR, Deanfield, J, ?, ?, Cleveland, T, Collier, D, Dasgupta, Indranil   +31 more
core   +1 more source

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes, Leonardo Cruz‐Criollo, Eric Kontowicz, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López‐Frías, Ameer E. Hassan, Samantha Miller, Elena Zapata‐Arriaza, Asier de Albóniga‐Chindurza, Mauro Bergui, Stefano Molinaro, João André Sousa, Fábio Gomes, João Sargento‐Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena‐Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Catarina Perry da Câmara, Anderson Brito, Nashwa Abdelhakim, Isabel Fragata, Dileep R. Yavagal, Jude H. Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor G. Jovin, Francesco Biraschi, Francesca Richetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikolaos Ntoulias, Marios Psychogios, Mariano Velo, Joaquín Zamarro, Gonzalo de Paco, Yazan Ashouri, Mohammad AlMajali, Juan F. Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena, Santiago Ortega‐Gutierrez   +75 more
wiley   +1 more source

Kidney function in the very elderly with hypertension: data from the hypertension in the very elderly (HYVET) trial.

, 2013
BACKGROUND: numerous reports have linked impaired kidney function to a higher risk of cardiovascular events and mortality. There are relatively few data relating to kidney function in the very elderly. METHODS: the Hypertension in the Very Elderly Trial (
Narkiewicz, Krzysztof, Beckett, Nigel, Fagard, Robert, Bulpitt, Christopher, Wang, Nan, Fletcher, Astrid, Peters, Ruth, Nitsch, Dorothea, Burch, Lisa, Li, Mengying, Poulter, Ruth   +10 more
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source