Results 81 to 90 of about 2,600,943 (336)

Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells

Stem Cell Research & Therapy, 2023
Background Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells (MSCs).
Logan M. Glasstetter, Tomiwa S. Oderinde, Mohit Mirchandani, Kamalnath Sankaran Rajagopalan, Samer H. Barsom, Roman Thaler, Sarosh Siddiqi, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Andre J. van Wijnen, Alfonso Eirin, Lilach O. Lerman   +13 more
doaj   +1 more source

Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice

Diabetology & Metabolic Syndrome
Background Roux-en-Y gastric bypass (RYGB) surgery is an effective metabolic surgery against diabetes and obesity. Clinical evidence indicates that patients with severe obesity have a poor curative effect in losing weight if they suffer from leptin or ...
Dan Tong, Jie Xiang, Wei Liu, Fang Sun, Lijuan Wang, Aidi Mou, Tingbing Cao, Qing Zhou, Mei You, Yingying Liao, Peng Gao, Daoyan Liu, Zongshi Lu, Zhiming Zhu   +13 more
doaj   +1 more source

Prognostic impact of increased pulse pressure/stroke index in a registry of hypertensive patients: the Campania Salute Network

Blood Pressure, 2019
Objectives: Increased arterial stiffness is associated with advanced arteriosclerosis, abnormal left ventricular (LV) geometry and function. Whether increased arterial stiffness is associated with incident cardiovascular (CV) event (MACE), independent of
Costantino Mancusi, Maria Angela Losi, Raffaele Izzo, Eva Gerdts, Grazia Canciello, Maria Immacolata Arnone, Bruno Trimarco, Giovanni de Simone, Nicola De Luca   +8 more
doaj   +1 more source

Epidermal growth factor receptor activation is essential for kidney fibrosis development

Nature Communications, 2023
Fibrosis is the progressive accumulation of excess extracellular matrix and can cause organ failure. Fibrosis can affect nearly every organ including kidney and there is no specific treatment currently.
Shirong Cao, Yu Pan, Andrew S. Terker, Juan Pablo Arroyo Ornelas, Yinqiu Wang, Jiaqi Tang, Aolei Niu, Sarah Abu Kar, Mengdi Jiang, Wentian Luo, Xinyu Dong, Xiaofeng Fan, Suwan Wang, Matthew H. Wilson, Agnes Fogo, Ming-Zhi Zhang, Raymond C. Harris   +16 more
doaj   +1 more source

Obesity and Hypertension

Annals of Internal Medicine, 1985
There is a close association of obesity with hypertension through mechanisms not now understood. Hypertension occurs frequently in industrialized societies where weight gain with advancing years is a common feature and is rare in primitive societies where weight and age are negatively correlated. Hemodynamically, obesity is characterized by an expanded
openaire   +7 more sources

Evidence Based Treatment for Excessive Alcohol Consumption and Concurrent Hypertension [PDF]

, 2020
Purpose. Excessive alcohol consumption is a preventable risk factor for hypertension, heart disease, and stroke. Though alcohol-related deaths number 88,000 annually in the U.S., alcohol use has the lowest treatment rate of behavioral health disorders at
Ward, Kimberly Ann
core   +1 more source

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif, Georgios Mangioris, Binxia Yang, Vanessa K. Pazdernik, Jeffrey W. Britton, Divyanshu Dubey, Eoin P. Flanagan, Sarosh R. Irani, Gregory S. Day, Charles L. Howe, A. Sebastian López‐Chiriboga, Andrew McKeon, John R. Mills, Yahel Segal, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +17 more
wiley   +1 more source

Effects of Non‐Aspirin Nonsteroidal Anti‐Inflammatory Drugs on Acute Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite celecoxib, a cyclooxygenase‐2 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation‐mediated perihematomal edema in rat models, the evidence of its effects on patient outcomes remains limited.
Shin‐Joe Yeh, Sung‐Chun Tang, Li‐Kai Tsai, Jiann‐Shing Jeng   +3 more
wiley   +1 more source

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source

Poor sleep quality was associated with increased plasma aldosterone concentration in community dwellers, a cross-sectional study

Scientific Reports
Sleep is implicated in circulating aldosterone, whereas effects of overall sleep quality are not characterized. Therefore, we explored relationship of sleep quality with plasma aldosterone concentration (PAC) in general population.
Xiufang Li, Mulalibieke Heizhati, Mei Li, Ling Yao, Ting Wu, Wenbo Yang, Lin Gan, Hui Wang, Miaomiao Liu, Adalaiti Maitituersun, Mengyue Lin, Jing Hong, Nanfang Li   +12 more
doaj   +1 more source