Results 41 to 50 of about 3,374,250 (258)

Hyperthermia induced pathophysiology of the central nervous system

, 2003
This review is focused on the pathophysiology of the central nervous system (CNS) associated with mild-to-moderate hyperthermia (body temperature > 37°C but <40°C) induced thermal stress in Human cases as well as whole body hyperthermia (WBH) in ...
Sharma, Har Shanker,, Hoopes, P.J., H. S. Sharma, P. J. Hoopes   +3 more
core   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Maternal exercise reduces hyperthermia-induced apoptosis in developing mouse brain

, 2011
Purpose: Hyperthermia-induced apoptosis is mediated by mitochondrial pathway, and is temporally correlated with alterations in mitochondrial morphology in neuroepithelial cells.
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core   +1 more source

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Modification of thermosensitivity and chemosensitivity induced by combined treatments with hyperthermia and adriamycin [PDF]

, 2001
Both adriamycin (ADM) and hyperthermia show thermal chemo-enhancement. Tolerance induction against ADM in heated cells has been reported resulting in clinical difficulty of cancer therapy.
Hayashi, Sachiko, Hatashita, Masanori, Tsuji, Koh, Jin, Zhao-Hui, Furukawa-Furuya, Masayo, Matsumoto, Hideki, Kano, Eiichi, Ohtsubo, Toshio, Yoshikawa, Shinji, Kitai, Ryuhei   +9 more
core  

The possible use of combined electrical impedance and ultrasound velocity measurements for the non-invasive measurement of temperature during mild hyperthermia [PDF]

, 2013
This paper explores the possibility of using combined measurements of electrical impedance and changes in ultrasound time of flight for determining deep body temperature during mild hyperthermia. Simultaneous electrical impedance spectra (1 kHz–1024 kHz)
Hale, Rebecca, Taylor, Matthew S., Wilson, Adrian J., Islam, Naimul   +3 more
core   +1 more source

Membrane‐Bound Multimodal Plasmonic Transducers for Noninvasive, In Situ Monitoring and Control of CAR T Cells Against Heterogeneous Solid Tumors

Advanced Materials, EarlyView.
Membrane‐bound multimodal transducers enable longitudinal ultrasound‐guided photoacoustic monitoring and in situ thermal control of CAR T cells in heterogeneous solid tumors. Imaging correlates T cell trafficking with tumor response, distinguishing responders from nonresponders.
Myeongsoo Kim, Ali Zamat, Melissa Cadena, Chloé Thiveaud, Riya Sen, Jeungyoon Lee, Elif Kulaksizoglu, S. Abbey Oliver, Don VanderLaan, Sydney Fábrega, Zizhen Zha, Kelsey P. Kubelick, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +14 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Quality assurance guidelines for interstitial hyperthermia [PDF]

, 2019
Quality assurance (QA) guidelines are essential to provide uniform execution of clinical hyperthermia treatments and trials. This document outlines the clinical and technical consequences of the specific properties of interstitial heat delivery and ...
Stauffer, P. R., Crezee, J., Van Rhoon, G. C., Strnad, V.,, Kukiełka, A. M., Hurwitz, M. D., Abdel-Rahman, S.,, Schmidt, M.,, Ghadjar, Pirus, Strnad, V., Kok, H. P.,, Gordeyev, S. S.,, Abdel-Rahman, S, Nadobny, J., Diederich, C. J., Ghadjar, P., Lamprecht, U.,, Ghadjar, Pirus,, Schmidt, M., Kok, H. P., Nadobny, J.,, Gordeyev, S. S., Marder, D., Vujaskovic, Z., Dobšíček Trefná, H., Van Rhoon, G. C.,, Abdel-Rahman, S., Dobsicek Trefna, Hana,, Lamprecht, U., Dobsicek Trefna, Hana, Kukiełka, A. M.,, Vujaskovic, Z.,, Stauffer, P. R.,, Diederich, C. J.,, Crezee, J.,, Marder, D.,, Hurwitz, M. D.,   +36 more
core   +1 more source