RCTs: ‘Gold Standard’ for Medical Research Targets Improved Outcomes [PDF]
, 2014 For decades, prospective randomized clinical trials (RCTs) have been the “gold standard” for medical research. These studies randomly assign patients to one of two groups: half receive the standard treatment, and half undergo the experimental approach ...
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Resisted adduction in hip neutral is a superior provocation test to assess adductor longus pain:an experimental pain study [PDF]
, 2015 The criterion of long-standing groin pain diagnoses in athletes usually relies on palpation and clinical tests. An experimental pain model was developed to examine the clinical tests under standardized conditions.
Chiarelli, P. +7 more
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Acta Paediatrica, EarlyView.ABSTRACT Aim Children with cystic fibrosis (CF) face substantial daily treatment burdens and the effects of transmembrane conductance regulator modulators on these have not been sufficiently described. We evaluated changes in treatment burden after elexacaftor tezacaftor ivacaftor (ETI) was initiated.
Marcus Svedberg +5 more
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Trials, 2017 Background Hyponatremia is the most common electrolyte imbalance encountered in clinical practice, associated with increased mortality and length of hospital stay. However, no high-quality evidence regarding whether hypertonic saline is best administered
Anna Lee +11 more
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Comparison of normal saline, hypertonic saline albumin and terlipressin plus hypertonic saline albumin in an infant animal model of hypovolemic shock. [PDF]
PLoS ONE, 2015 In series of cases and animal models suffering hemorrhagic shock, the use of vasopressors has shown potential benefits regarding hemodynamics and tissue perfusion.
Javier Urbano +8 more
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Management of hyperkalemia in the acutely ill patient. [PDF]
, 2019 PURPOSE:To review the mechanisms of action, expected efficacy and side effects of strategies to control hyperkalemia in acutely ill patients. METHODS:We searched MEDLINE and EMBASE for relevant papers published in English between Jan 1, 1938, and July 1,
Dépret, François +5 more
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Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial
BJU International, Volume 135, Issue 4, Page 638-647, April 2025.Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui +2 more
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Egyptian Journal of Critical Care Medicine, 2021 Introduction Septic shock remains an impatient cause of morbidity and mortality. A cascade of inflammatory mediators released cause misdistribution of blood flow and organ perfusion.
Hassan S. Effat +3 more
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Effects of Hypertonic Saline Solution on Clinical Parameters, Serum Electrolytes and Plasma Volume in the Treatment of Haemorrhagic Septicaemia in Buffaloes [PDF]
, 2010 This study was conducted to determine the efficacy of hypertonic saline solution (HSS) along with antibiotic (ceftiofur HCl) and non-steroidal anti-inflammatory drug (ketoprofen) in the treatment of haemorrhagic septicaemia in buffaloes. For this purpose,
M. Arif Zafar*, G. Muhammad, Zafar Iqbal1 and M. Riaz2
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A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants [PDF]
, 2016 OBJECTIVE: Acute bronchiolitis is a common disorder of infants that often results in hospitalization. Apart from supportive care, no therapy has been shown to influence the course of the disease, except for a possible effect of nebulized hypertonic ...
Flores, P, Mendes, AL, Neto, AS
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