Results 61 to 70 of about 906 (141)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Secondary Adrenal Insufficiency Presenting With Severe Hyponatremia in an Elderly Patient With Primary Aldosteronism Suggesting Underlying Autonomous Cortisol Secretion

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Possible unrecognized cortisol autonomy in primary aldosteronism may suppress the hypothalamic–pituitary–adrenal axis. Under physiological stress, this may contribute to secondary adrenal insufficiency and severe hyponatremia. Clinicians should consider adrenal insufficiency in patients with primary aldosteronism presenting with unexplained ...
Minami Toda, Shunsuke Takahashi, Hitomi Saito, Honami Mori, Yutaka Kuroda, Akito Maeshima   +5 more
wiley   +1 more source

The Renal Function of the Wild Rodent Cerradomys goytaca Reveals Adaptations in the Mechanisms of Urinary Concentration and Solute Excretion

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 7, Page 772-784, August 2026.
Renal adaptations of Cerradomys goytaca associated with survival in its natural habitat. Graphical Abstract of the main renal physiological characteristics identified in C. goytaca. This species exhibits an increased kidney mass index, elevated urine osmolality, and enhanced tubular water reabsorption, indicating a higher capacity for water ...
Luzia Agusta Valeriano‐Monici, Carolina de Augusta Barros Silva, Gustavo de Castro Nascimento, Lana Soares Sales, Carlos de Alberto Souza Filho, Edgar Mendes Souza Wan Der Maas Rosa, Patrick Gabriel Alencar dos Santos, Eulogio de Carlos Queiroz Carvalho, Jones Bernardes Graceli, Pablo Rodrigues Gonçalves, Jackson de Souza‐Menezes   +10 more
wiley   +1 more source

Hypertonic saline and reduced peroxynitrite formation in experimental pancreatitis

Clinics, 2011
OBJECTIVES: In this study, we tested the hypothesis that hypertonic saline exerts anti-inflammatory effects by modulating hepatic oxidative stress in pancreatitis.
Ester Correia Sarmento Rios, Ana Soares Moretti, Irineu Tadeu Velasco, Heraldo Possolo de Souza, Fatima Abatepaulo, Francisco Soriano   +5 more
doaj   +1 more source

What Matters Most: A Case of Pemphigus Vulgaris in a Nonagenarian Physician

Journal of the American Geriatrics Society, EarlyView.
Svetlana Bagdasarov, Loma Dave, Alan Sang, Lisa Zhou, Billie Fyfe‐Kirschner, Ying Guo, Ibiyonu Lawrence   +6 more
wiley   +1 more source

Admission Plasma Lipopolysaccharide‐binding protein, Procalcitonin, and Lactate for Early Identification of Nosocomial Infection in Cirrhotic Patients With Upper Gastrointestinal Bleeding: A Retrospective Analysis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT This study aimed to assess whether admission plasma lipopolysaccharide‐binding protein (LBP), procalcitonin (PCT), and lactate could improve detection of nosocomial infection in cirrhotic patients presenting with upper gastrointestinal bleeding (UGIB).
Li Chen, Shan‐Shan Dun, Fang Xiao
wiley   +1 more source

Hypertonic Saline [PDF]

JACC: Heart Failure, 2020
openaire   +2 more sources

Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats

International Journal of Vascular Medicine, 2016
Background. Angiotensin 1-7 (Ang1-7) plays an important role in renal circulation. Hemorrhagic shock (HS) may cause kidney circulation disturbance, and this study was designed to investigate the renal blood flow (RBF) response to Ang1-7 after HS. Methods.
Maryam Maleki, Mehdi Nematbakhsh
doaj   +1 more source

Effect of hypertonic saline on hypotension following induction of general anesthesia: A randomized controlled trial

Advanced Biomedical Research, 2014
Background: The aim of this study was to examine the effects of preoperatively administered i.v. hypertonic saline on hypotension following induction of general anesthesia.
Parviz Kashefi, Kamran Montazeri, Seyed Taghi Hashemi   +2 more
doaj   +1 more source

Renal Phosphate Reabsorption in Humans Depends on at Least Three Distinct Transporters Unlike in Mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Aim Kidney excretion of phosphate is the gatekeeper of systemic phosphate homeostasis as evident from inborn and acquired diseases. Renal phosphate transporters are a promising target for phosphate‐lowering drugs, but molecular details of human kidney phosphate handling are largely unknown.
Ashley L. Fernandes, Laurine Lang, Jürgen Klar, Anja Giese, Alexander Ehrmann, Rupert Busch, Hannah Auwerx, Christoph Daniel, Nati Hernando, Isabel Rubio‐Aliaga, Carsten A. Wagner   +10 more
wiley   +1 more source