Results 121 to 130 of about 22,232 (242)

Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Cultured white adipocytes exposed to 31°C undergo cell‐autonomous metabolic adaptation characterized by enhanced mitochondrial function and widespread remodeling of the mitochondrial acetylome. Acetyl‐proteomic and metabolomic profiling identified mitochondria‐associated proteins, including SHMT2 and PCCA, whose acetylation changes were linked to ...
Hiroyuki Mori, Hadla Hariri, William Moe, Sophia Durham, Yuridia Guzman, Emma Paulsson, Rachel C. Simmermon, Parth B. Bhanderi, Sydney K. Peterson, Mia J. Dickson, Charles R. Evans, Ormond A. MacDougald   +11 more
wiley   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 544-550, August 2026.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Phenotype Expansion of Malan Syndrome: New Cases and a Review of the Literature

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1783-1798, August 2026.
ABSTRACT Malan syndrome is an ultra‐rare overgrowth syndrome caused by pathogenic variants or deletions in nuclear factor one X (NFIX) located at 19p13.2. Here, we report a comprehensive literature review and phenotyping of known patients with Malan syndrome and present a novel cohort of eight patients.
Alex F. Nisbet, Sylvie A. Adams, Zoe S. Katz, Christal G. Delagrammatikas, Kosuke Izumi, Winifred Sigal, Kim Ventarola, Elaine H. Zackai, Julia E. Reid, Grant T. Liu, Jennifer M. Kalish   +10 more
wiley   +1 more source

Shockwave Therapy or Acupoint Stimulation Combined With Physiotherapy for Spasticity and Motor Function in Post‐Stroke Recovery: A Randomized Controlled Trial

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Stroke frequently causes spasticity and motor impairment, reducing independence. Non‐invasive treatments like radial extracorporeal shockwave therapy (ESWT) and acupoint‐based transcutaneous electrical nerve stimulation (Acu‐TENS) show potential, but direct comparisons with physiotherapy are limited.
Kazi Md Azman Hossain, Meer Hossain Hero, Mahomuda Afroze, Saddam Hossain, Md. Adnan Ibne Reza, Tofajjal Hossain, Ahamadullah Hil Galeb, Jannatul Ferdous Rikti, Mahdi Ul Bari, Arnob Datta   +9 more
wiley   +1 more source

Secondary Adrenal Insufficiency Presenting With Severe Hyponatremia in an Elderly Patient With Primary Aldosteronism Suggesting Underlying Autonomous Cortisol Secretion

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Possible unrecognized cortisol autonomy in primary aldosteronism may suppress the hypothalamic–pituitary–adrenal axis. Under physiological stress, this may contribute to secondary adrenal insufficiency and severe hyponatremia. Clinicians should consider adrenal insufficiency in patients with primary aldosteronism presenting with unexplained ...
Minami Toda, Shunsuke Takahashi, Hitomi Saito, Honami Mori, Yutaka Kuroda, Akito Maeshima   +5 more
wiley   +1 more source

Effects of lactate-based therapies on intracranial pressure and brain metabolism of patients with acute brain injury: a systematic review. [PDF]

Crit Care
Romero García N, Ruiz Zarco A, Ruiz Pacheco A, Úbeda Mata S, Milian JM, Monleón B, Segura Marín N, Oddo M, Bouzat P, Resch P, Annoni F, Taccone FS, Robba C, Badenes R.   +13 more
europepmc   +1 more source

Symptomatic Management of Sudden Unilateral Severe Spasticity Following a Fall in a Patient With Traumatic Spinal Cord Injury: A Case Report—From Etiology To Symptom‐Focused

Clinical Case Reports, Volume 14, Issue 8, August 2026.
This graphic abstract details the case of a 26‐year‐old male with a history of chronic traumatic spinal cord injury (TSCI), who achieved wheelchair‐dependent independence following 6 years of rehabilitation. A fall incident precipitated sudden and uncontrollable spasticity in the patient's right lower limb.
Juchuan Dong, Yongmei Li, Yongqian Han, Fuhou Zhang, Shaofang Li, Lihua Jin   +5 more
wiley   +1 more source

Hypertonic thermal solutions as a putative strategy for respiratory biofilm disruption. [PDF]

Open Med (Wars)
Falcone M, Pietrangelo L, Guarnieri A, Brancazio N, Venditti N, Di Naro M, Petronio Petronio G, Di Marco R, Varricchio A.   +8 more
europepmc   +1 more source

CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang, Xinbo Ji, Han Yu, Jingwen Xu, Yu Wang, Ping Sun, Yingxin Wang, Yao Tang, Zexin Zhan, Yichang Jiao, Didi Shan, Pengfei Lin, Dong‐dong Wang, Yuying Zhao, Xianyang Liu, Chuanzhu Yan, Jianqiao Li, Mingfeng Li, Fuchen Liu, Shengping Hou   +19 more
wiley   +1 more source