Results 41 to 50 of about 78,803 (280)

Cumulative Burden of Morbidity Among Testicular Cancer Survivors After Standard Cisplatin-Based Chemotherapy: A Multi-Institutional Study [PDF]

, 2018
Purpose In this multicenter study, we evaluated the cumulative burden of morbidity (CBM) among > 1,200 testicular cancer survivors and applied factor analysis to determine the co-occurrence of adverse health outcomes (AHOs).
AnnaLynn M. Williams, Christian Kollmannsberger, Chunkit Fung, Clair Beard, Darren R. Feldman, David J. Vaughn, Deepak M. Sahasrabudhe, Howard D. Sesso, Jeri Kim, Lawrence H. Einhorn, Lois B. Travis, Mohammad I. Abu Zaid, null null, Patrick O. Monahan, Robert A. Huddart, Robert J. Hamilton, Ryan Cook, Sarah L. Kerns, Shirin Ardeshir-Rouhani-Fard, Sophie D. Fossa, Timothy E. Stump   +20 more
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

COVID-19-associated hypertriglyceridemia and impact of treatment

Frontiers in Medicine
BackgroundCoronavirus disease 2019 (COVID-19) associated hypertriglyceridemia was observed among patients admitted to intensive care units (ICU) in Qatar.
Rasha Kaddoura, Mohamed Izham Mohamed Ibrahim, Maha Al-Amri, Arun Prabhakaran Nair, Ahmad Alharafsheh, Sumaya Alsaadi Alyafei, Mutaz Albakri   +6 more
doaj   +1 more source

Hypertriglyceridemia and Recurrent Pancreatitis following Splenectomy

Case Reports in Gastroenterology, 2007
Hyperlipoproteinemia represents a constellation of clinical syndromes that frequently includes hypertriglyceridemia. Because of the degree of elevation in the triglyceride levels frequently seen in these syndromes, they are associated with complications ...
Michael Butman, David Taylor, Kristina Boström, Manuel Quinones, Susanne B. Nicholas   +4 more
doaj   +1 more source

An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. [PDF]

, 2019
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for ...
Cheang, Rachel T, Chen, Tzu-Chieh, Fitch, Mark D, Gray, Nora E, Hellerstein, Marc K, Kanamaluru, Deepthi, Lee, Justin Y, Lee, Rebecca A, Tan, Jenna H, Tsai, Sam L, Wang, Jen-Chywan, Yiv, Nicholas   +11 more
core  

Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status [PDF]

, 2020
Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular.
Barber, Thomas M., Coussa, Ayla, Hassan, Hayder   +2 more
core   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

Disease Models & Mechanisms, 2015
Apolipoprotein C-II (APOC2) is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis ...
Chao Liu, Keith P. Gates, Longhou Fang, Marcelo J. Amar, Dina A. Schneider, Honglian Geng, Wei Huang, Jungsu Kim, Jennifer Pattison, Jian Zhang, Joseph L. Witztum, Alan T. Remaley, P. Duc Dong, Yury I. Miller   +13 more
doaj   +1 more source

Associations of Hypertriglyceridemia Onset Age With Cardiovascular Disease and All‐Cause Mortality in Adults: A Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Limited studies have involved new‐onset hypertriglyceridemia, and this study was to evaluate the associations of hypertriglyceridemia onset age with cardiovascular diseases (CVD) and all‐cause mortality.
Hui Zhou, Xiong Ding, Qing Yang, Shuohua Chen, Yun Li, Xin Zhou, Shouling Wu   +6 more
doaj   +1 more source

Recombinant gamma interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients. [PDF]

, 1986
Animals suffering from malignancy or chronic infection develop characteristic metabolic abnormalities, including a well-defined hypertriglyceridemic state.
Bradley, WA, Gianturco, SH, Gutterman, JU, Kurzrock, R, Quesada, JR, Rohde, MF, Sherwin, SA   +6 more
core