Computational Modeling of Cardiac Growth and Remodeling in Pressure Overloaded Hearts -- Linking Microstructure to Organ Phenotype [PDF]
Acta Biomaterialia, 2020, 2020 Cardiac growth and remodeling (G&R) refers to structural changes in myocardial tissue in response to chronic alterations in loading conditions. One such condition is pressure overload where elevated wall stresses stimulate the growth in cardiomyocyte thickness, associated with a phenotype of concentric hypertrophy at the organ scale, and promote ...
arxiv +1 more source
Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. [PDF]
, 2019 IntroductionDysferlin loss-of-function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin-like growth factor 1 (IGF-1) could provide benefit but may cause ...
Barton, Elisabeth R +9 more
core +1 more source
Unilateral lateral mass hypertrophy: An extremely rare congenital anomaly of Atlas
Journal of Craniovertebral Junction and Spine, 2013 A wide variety of congenital anomalies are observed around the craniovertebral junctional area. However, hypertrophied unilateral lateral mass of atlas in association with chiari-1 malformation leading to myelopathy is extremely uncommon.
Kuntal Kanti Das +5 more
doaj +1 more source
Whole-slide image analysis outperforms micrograph acquisition for adipocyte size quantification
Adipocyte, 2020 The distinction between biological processes of adipose tissue expansion is crucial to understanding metabolic derangements, but a robust method for quantifying adipocyte size has yet to be standardized.
Anne S Maguire +5 more
doaj +1 more source
Self-supervised contrastive learning of echocardiogram videos enables label-efficient cardiac disease diagnosis [PDF]
, 2022 Advances in self-supervised learning (SSL) have shown that self-supervised pretraining on medical imaging data can provide a strong initialization for downstream supervised classification and segmentation. Given the difficulty of obtaining expert labels for medical image recognition tasks, such an "in-domain" SSL initialization is often desirable due ...
arxiv +1 more source
Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]
, 2015 Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT +5 more
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Hypertrophy of the Turbinate. [PDF]
JAMA: The Journal of the American Medical Association, 1907 Brookings, S. D., March 4, 1907. To the Editor: —After reading with interest the article of Dr. Kuyk inThe Journalof March 2, in which he describes his method of dealing with hypertrophy of the inferior turbinate, I am prompted to describe a method which has proved successful in my hands. The observations of Dr.
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Lipomatous septal hypertrophy [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2009 A 76-year old obese woman with a body mass index (BMI) of 36.8 was referred for evaluation of an intracardiac mass, incidentally detected with computed tomography (CT). The CT scan showed massive thickening of the intra-atrial septum with the septal tissue clearly hypointense to normal myocardium and isointense to subcutaneous fat (Figure 1, A) and ...
Claudia Plachtzik +2 more
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Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise.
Journal of applied physiology, 2019 One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that occurs in response to resistance exercise. A large body of work shows that a mammalian target of rapamycin complex 1 (mTORC1)-mediated increase of muscle protein ...
H. Wackerhage +4 more
semanticscholar +1 more source
Comorbid CAD and Ventricular Hypertrophy Compromise The Perfusion of Myocardial Tissue at Subcritical Stenosis of Epicardial Coronaries [PDF]
, 2018 BACKGROUND: Most studies of CAD revascularization have been based on and reported according to angiographic criteria which don't consider the relation between the resulting effective flow distal to the stenosis and the demand of a hypertrophied myocardial tissue.
arxiv +1 more source