Results 101 to 110 of about 57,118 (288)

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 120-130, January 2026.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

Hyperuricemia as cardiovascular risk factor in patients with hypothyroidism [PDF]

, 2016
Thyroid dysfunction is associated with dyslipidemia, a well-known cardiovascular risk factor. Besides dyslipidemia, thyroid dysfunction can induce insulin resistance, hypertension, endothelial dysfunction.
Chukwunonso, Arinze, Obinna, Nwokiea Chukwuma   +1 more
core  

Associations of body mass index and remnant cholesterol with hyperuricemia in patients with hypertension

BMC Endocrine Disorders
Background There is a paucity of prior research on residual cholesterol (RC) and hyperuricemia, and it remains unclear whether body mass index (BMI) functions as a mediating factor between them or intensifies lipid metabolic dysregulation, thereby ...
Wei Zhou, Tao Wang, Lingjuan Zhu, Yumeng Shi, Chao Yu, Huihui Bao, Xiaoshu Cheng   +6 more
doaj   +1 more source

Association of serum uric acid with proteinuria in type 2 diabetic patients [PDF]

, 2013
Background: Various findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy.
Baradaran, A., Behradmanesh, S., Karami Horestani, M., Nasri, H.   +3 more
core   +3 more sources

Fatal Tumor Lysis Syndrome Induced by Pembrolizumab in Advanced Renal Pelvis Cancer

IJU Case Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Tumor lysis syndrome (TLS) arises from the rapid breakdown of tumor cells during oncological treatment. Although TLS is rarely observed in solid tumors, few studies have documented instances of TLS associated with pembrolizumab. This report presents a case involving pembrolizumab‐induced TLS.
Takashi Asakura, Toshiaki Shinojima, Shinnosuke Hiruta, Hirotaka Asakura   +3 more
wiley   +1 more source

Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications

Diabetes, Metabolic Syndrome and Obesity, 2020
Min Gong, Song Wen, Thiquynhnga Nguyen, Chaoxun Wang, Jianlan Jin, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of ...
Gong M, Wen S, Nguyen T, Wang C, Jin J, Zhou L   +5 more
doaj  

Hyperuricemia in Renal patients: Treat or not to treat [PDF]

, 2021
Abbasi Muhammad Tanzeel, Asghar Muhammad Rashid, Bashir Khuram, Muhammad Nauman Hashmi   +3 more
openalex   +1 more source

Bladder Amyloidosis With Pulmonary Lesions: A Case of Spontaneous Remission After Transurethral Resection

IJU Case Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Bladder amyloidosis is a rare condition characterized by amyloid fibril deposition in the bladder, often mimicking bladder cancer. Diagnosis requires histological analysis of the examination, and treatment typically involves transurethral resection. Case Presentation An 80‐year‐old male presented with gross hematuria.
Suguru Ito, Takuma Suzuki, Ryo Sato, Kunihiko Maeda, Shinta Suenaga, Hidenori Kanno, Sadanobu Sato, Shigemitsu Horie, Sei Naito, Norihiko Tsuchiya   +9 more
wiley   +1 more source

Retrospective Case Series of Fulminant Metabolic Crisis in GSDIA: Persistent Lactic Acidosis Despite Correction of Hypoglycemia May Reflect Secondary Mitochondrial Dysfunction

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Although several advances in glycogen storage disorder (GSD) management have been made over the years, there is still increased morbidity and mortality in these patients, particularly among those with GSD type I (GSDI). Here, we describe a case series of five patients with GSDIa who presented with severe lactic acidosis and passed away without
Herodes Guzman, Nicole Stewart, Lauren Mitteer, Victoria Sanders, Rebecca Ganetzky, Diva D. De Leon   +5 more
wiley   +1 more source

Relationship of hyperuricemia with mortality in heart failure patients with preserved ejection fraction [PDF]

, 2015
Takeshi Shimizu, Akiomi Yoshihisa, Yuki Kanno, Mai Takiguchi, Akihiko Sato, Shunsuke Miura, Yuichi Nakamura, H. Yamauchi, Takashi Owada, Satoshi Abe, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu‐ichi Saitoh, Yasuchika Takeishi   +19 more
openalex   +1 more source