Results 31 to 40 of about 70,452 (325)

Association of impaired sensitivity to thyroid hormones with hyperuricemia through obesity in the euthyroid population

Journal of Translational Medicine, 2023
Quetions To what extent is impaired sensitivity to thyroid hormones associated with hyperuricemia through body mass index (BMI) in the euthyroid population?
Zhiyuan Wu, Yue Jiang, Pingan Li, Yutao Wang, Haiping Zhang, Zhiwei Li, Xia Li, Lixin Tao, B. Gao, Xiuhua Guo   +9 more
semanticscholar   +1 more source

Association between weight-adjusted-waist index and the risk of hyperuricemia in adults: a population-based investigation

Frontiers in Endocrinology, 2023
Objective This investigation sought to elucidate the potential correlation between a recently characterized adiposity metric, termed the Weight-Adjusted-Waist Index (WWI) and hyperuricemia.
Yunyi Ding, Zhuohan Xu, Xue Zhou, Yichen Luo, Ruijie Xie, Yayu Li   +5 more
semanticscholar   +1 more source

Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

BMC Endocrine Disorders, 2023
Background and aims Chronic kidney disease (CKD) is a public health concern worldwide and has been recognized as a significant risk factor for cardiovascular disease.
Z. Barman, Mahmudul Hasan, Rakib Miah, Ananya Dutta Mou, Jaasia Momtahena Hafsa, Aporajita Das Trisha, Firoz Mahmud, Nurshad Ali   +7 more
semanticscholar   +1 more source

Linear and non-linear Mendelian randomization analyses of sex-specific associations between sleep duration and hyperuricemia

Frontiers in Nutrition, 2022
BackgroundObservational studies have suggested a potential non-linear association between sleep duration and hyperuricemia. However, the causal nature and sex-specific differences are poorly understood.
Chenfeng Zou, Zhenqian Wang, Wenyu Huang, Jiawen Lu, Vivian Yawei Guo, Yuying Zhang, Shufei Zang, Jinying Yang, Liyuan Han, Guozhi Jiang   +9 more
doaj   +1 more source

The Role of the Intestine in the Development of Hyperuricemia

Frontiers in Immunology, 2022
Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout.
Hui-ming Yin, Na Liu, Jie Chen
semanticscholar   +1 more source

Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Frontiers in Cellular and Infection Microbiology, 2022
The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. The gut microbiota, which colonizes the human intestine, has a mutually beneficial and symbiotic relationship with the host and plays a ...
Zhilei Wang, Yuchen Li, Wenhao Liao, Ju Huang, Yanping Liu, Zhiyong Li, Jianyuan Tang   +6 more
semanticscholar   +1 more source

Prevalence of Hyperuricemia Among Chinese Adults: Findings From Two Nationally Representative Cross-Sectional Surveys in 2015–16 and 2018–19

Frontiers in Immunology, 2021
Objective To determine the nationwide prevalence of hyperuricemia in China and evaluate its trends and associated risk factors. Methods Using a multi-stage, stratified, cluster-randomized sampling design, two cross-sectional surveys (representative of ...
Mei Zhang, Xiaoxia Zhu, Jing Wu, Zheng-jing Huang, X. Zhang, Yu Xue, W. Wan, Chun Xing Li, Zhenping Zhao, Linhong Wang, Limin Wang, H. Zou, Maigeng Zhou   +12 more
semanticscholar   +1 more source

Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]

, 2016
BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc, Hagerty, David T, Hyndman, David, Iverson, Cory, Liu, Sha, Manhard, Kimberly, Miner, Jeffrey N, Nanavati, Payal, Quart, Barry, Shen, Zancong, Tan, Philip K, Terkeltaub, Robert, Yeh, Li-Tain   +12 more
core   +2 more sources

What makes gouty inflammation so variable? [PDF]

, 2017
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core   +2 more sources

Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]

, 2020
Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro, Camandola, Simonetta, Cutler, Roy G., Feldman, Neil H., Haran, James B., Mattsona, Mark P., Seon Yoon, Jeong   +6 more
core   +1 more source