Results 51 to 60 of about 57,118 (288)

Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three‐period, partially replicated crossover design was used for the
Menghan Ye, Rui Zhang, Jing Wan, Jinping Zhou, Pengpeng Guo, Dianwen Yu, Peixia Li, Yani Liu, Shaojun Shi   +8 more
wiley   +1 more source

The Influence of Low Purine Diet and Physical Activity on Changing of Uric Acid Levels in Hyperuricemia [PDF]

, 2017
Hyperuricemia is caused by elevated levels of uric acid in the blood due to excessive production or reduced disposal. Factors that contribute to increased uric acid production are the consumption of foods that contain lots of purine and uric acid ...
Dewantari, N. M. (Ni), Kusumayanti, G. A. (G)   +1 more
core   +1 more source

Mechanism of flavonoids inhibiting xanthine oxidase and alleviating hyperuricemia from structure–activity relationship and animal experiments: A review [PDF]

, 2023
Hui Xue, Meng Xu, Deming Gong, Guowen Zhang   +3 more
openalex   +1 more source

Major adverse cardiovascular events and hyperuricemia during tuberculosis treatment.

PLoS ONE, 2023
BackgroundHyperuricemia is common during tuberculosis (TB) treatment, especially in association with pyrazinamide (PZA). This study investigated the relationship between major adverse cardiovascular events (MACEs) and hyperuricemia during TB treatment ...
Hong-Joon Shin, Joon-Young Yoon, Young-Ok Na, Jae-Kyeong Lee, Bo Gun Kho, Tae-Ok Kim, Yu-Il Kim, Sung-Chul Lim, Sae-Hee Jeong, Yong-Soo Kwon   +9 more
doaj   +1 more source

Effect Modification of Hyperuricemia, Cardiovascular Risk, and Age on Chronic Kidney Disease in China: A Cross-Sectional Study Based on the China Health and Nutrition Survey Cohort

Frontiers in Cardiovascular Medicine, 2022
IntroductionThe question of whether the increased burden of chronic kidney disease (CKD) is caused by the interaction of hyperuricemia and cardiovascular disease (CVD) risk factors or is accelerated by aging remains unresolved.
Yang Li, Yang Li, Yang Li, Bowen Zhu, Bowen Zhu, Bowen Zhu, Yeqing Xie, Yeqing Xie, Yeqing Xie, Shi Jin, Shi Jin, Shi Jin, Weiran Zhou, Weiran Zhou, Weiran Zhou, Yi Fang, Yi Fang, Yi Fang, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding   +20 more
doaj   +1 more source

Uric Acid, Arterial Stiffness and Blood Pressure: A Population-Based Cohort Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aim Serum uric acid (SUA) has long been linked to elevated blood pressure (BP) in observational clinical studies. Nonetheless, data regarding the correlation between SUA and BP are controversial in randomized controlled trials and mendelian randomization research.
Li L, Zheng M, Wang M, Wang C, Wu S, Xue H.   +5 more
europepmc   +2 more sources

Gout in pregnancy: Obstetric and neonatal outcomes

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 349-355, April 2025.
Abstract Objective The pregnancy, delivery, and neonatal outcomes of pregnancies complicated by gout have yet to be evaluated in a population‐based study. We sought to evaluate the obstetric and neonatal outcomes in pregnant patients with gout using a national population database.
Sam Amar, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan   +3 more
wiley   +1 more source

Associations of circulating multiple metals with the risk of incident hyperuricemia and the average annual change in uric acid levels

Ecotoxicology and Environmental Safety, 2023
Background: Hyperuricemia has been linked to exposure to certain metals in cross-sectional studies. However, prospective studies evaluating the associations of multiple metal exposures with incident hyperuricemia are scarce.
Jianjian Xu, Yutong You, Yu Yuan, Hao Wang, Tangchun Wu, Pinpin Long   +5 more
doaj   +1 more source

Clinical Relevance and Diagnostic Utility of Standard Serum Biomarkers in Advanced Chronic Kidney Disease: A Single‐Center Observational Study From Bangladesh

iLABMED, EarlyView.
This study evaluated conventional and emerging biochemical markers for assessing chronic kidney disease (CKD) progression in Bangladeshi patients elevated serum uric acid and parathyroid hormone levels, along with reduced eGFR, vitamin D, and albumin levels, were significantly associated with CKD, highlighting their potential as cost‐effective early ...
Fazlul Haque, Md. Samiul Islam, Nafsoon Rahman, Ayub Zawad, Sadia Afrin, Pulak Kanti Palit, Tanjil Hasan, Md. Isahak Ali, Shafin Ahmed, Akram Hossain, Marina Khatun, Tabassuma Marzia Prome, Md. Shah Alam, Ashekul Islam   +13 more
wiley   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source