Results 71 to 80 of about 47,286 (245)

Family History of Exceptional Longevity Is Associated with Lower Serum Uric Acid Levels in A shkenazi J ews [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91205/1/jgs3902 ...
Atzmon, Atzmon, Atzmon, Barzilai, Barzilai, Barzilai, Baxmann, Borges, Botev, Chobanian, Cockcroft, Coresh, Cutler, Dehghan, Edwards, Fang, Fliser, Fried, Fried, Geloneze, Gulbrandsen, Kim, Kim, Levey, Levey, Matthews, Obermayr, Oda, U.S. Renal Data System, Ward   +29 more
core   +1 more source

Probiotics in Alleviating Hyperuricemia: Research Status, Mechanism of Action and Challenges

Shipin gongye ke-ji
Hyperuricemia (HUA) is a chronic metabolic disease, characterized by excessive uric acid in the blood, caused by purine metabolism disorders. Studies show that conventional clinical treatment methods have certain limitations, while probiotics have the ...
Xinru YANG, Jiayue TANG, Xiaoqun ZENG, Zhen WU, Qiwei DU, Maolin TU   +5 more
doaj   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, EarlyView.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants. a multicenter case-control study in Italy. [PDF]

, 2018
Cardiovascular diseases are the leading causes of mortality and morbidity in Western countries. The possible synergistic effect of poor adherence to a Mediterranean diet (MD) and other risk factors for acute myocardial infarction (AMI) such as ...
Agati, L, Barillà, F, Colamesta, V, Di Murro, F, Ferrante, F, Firenze, A, La Torre, G, Mannocci, A, Maurici, M, Saulle, R, Siliquini, R   +10 more
core   +1 more source

Incidence of major cardiovascular events in patients with metabolic dysfunction‐associated steatotic liver disease in the general population

European Journal of Heart Failure, EarlyView.
Aims Major adverse cardiovascular events (MACE) related to cardiovascular disease are a major cause of death in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). We explored the impact of MASLD on incident MACE and overall mortality in the general population in Germany.
Yvonne Huber, Lea Hofmann, Jürgen H. Prochaska, Thomas Koeck, Julian Chalabi, Norbert Pfeiffer, Manfred Beutel, Konstantin Strauch, Karl J. Lackner, Oliver Tüscher, Thomas Münzel, Matthias M. Weber, Julia Weinmann‐Menke, Philipp Wild, Peter R. Galle, Jörn M. Schattenberg   +15 more
wiley   +1 more source

Wearable biosensors based on molecularly imprinted polymers

FlexMat, EarlyView.
Wearable biosensors based on molecularly imprinted polymers (MIPs) provide real‐time, non‐invasive monitoring of key biomarkers. This review highlights the research advances on MIPs‐based biosensors with enhanced selectivity, stability, and adaptability in flexible sensing platforms.
Xiangnan Li, Rongqi Ou, Zhen Yuan, Yuanjing Lin   +3 more
wiley   +1 more source

Exogenous chemical exposures and metabolic disruptions in hyperuricemia: a multi-omics mediation study

Environment International
Background: Hyperuricemia has emerged as a significant public health concern. However, the relationship between hyperuricemia and both individual and mixed exogenous chemicals remains poorly understood, and the underlying mechanisms are still unclear ...
Yang Ouyang, Lvyun Sun, Di Yu, Qi Li, Shanshan Du, Xiaolin Wang, Mengyao Wang, Guowang Xu, Weimin Ye, Xinyu Liu   +9 more
doaj   +1 more source

Independent and joint associations of body mass index, waist circumference, waist-height ratio and their changes with risks of hyperuricemia in middle-aged and older Chinese individuals: a population-based nationwide cohort study

Nutrition & Metabolism, 2021
Background Previous reports regarding the predictive power of adiposity indices remain inconsistent, and longitudinal studies on this top are limited. The associations of hyperuricemia risk with changes in obesity status, as well as the joint effects of ...
Zonglei Zhou, Kunpeng Li, Xianzhi Li, Rongsheng Luan, Ruzhen Zhou   +4 more
doaj   +1 more source

Gout in pregnancy: Obstetric and neonatal outcomes

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 349-355, April 2025.
Abstract Objective The pregnancy, delivery, and neonatal outcomes of pregnancies complicated by gout have yet to be evaluated in a population‐based study. We sought to evaluate the obstetric and neonatal outcomes in pregnant patients with gout using a national population database.
Sam Amar, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan   +3 more
wiley   +1 more source

Musculoskeletal ultrasonography in gout [PDF]

, 2015
Gout is a frequent inflammatory disease induced by the deposition of monosodium urate crystals in joints and extra-articular tissues. The natural history of the disease includes four different phases: asymptomatic hyperuricemia, acute attacks ...
Finucci, Annacarla, Iagnocco, Annamaria, Rutigliano, IOLANDA MARIA, Scirocco, Chiara   +3 more
core   +1 more source