Results 11 to 20 of about 28,514 (288)

Structure and function of the hypochlorous acid–induced flavoprotein RclA from Escherichia coli [PDF]

Journal of Biological Chemistry, 2020
In response to microbial invasion, the animal immune system generates hypochlorous acid (HOCl) that kills microorganisms in the oxidative burst. HOCl toxicity is amplified in the phagosome through import of the copper cation (Cu2+).
Yeongjin Baek, Jinwoo Kim, Jinsook Ahn, Inseong Jo, Seokho Hong, Sangryeol Ryu, Nam‐Chul Ha   +6 more
openalex   +2 more sources

Long-Term Efficacy of Chlorine-Based Disinfectants Vs Multi-Enzymatic Detergent with Hypochlorous Acid for Waterline Disinfection in Inactive Dental Chair Units [PDF]

Infection and Drug Resistance
Yu-Ying Zheng,1,2,* Yuan-Yuan Wang,1,3,* Qian Guo,1,4 Chan-Yuan Shen,1,5 Rong Huang,1,2 Li Wang,1,6 Huan Sun1,2 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry
Zheng YY, Wang YY, Guo Q, Shen CY, Huang R, Wang L, Sun H   +6 more
doaj   +2 more sources

Highly purified hypochlorous acid water facilitates glucose metabolism and memory formation in type 2 diabetic mice associated with altered-gut microbiota [PDF]

Scientific Reports
Hypochlorous acid (HOCl) is an endogenous oxidant and chlorinating agent in mammals that is effective against a broad range of microorganisms. However, the effects of exogenous HOCl on biological processes have not been reported.
Kazuki Watanabe, Yusuke Maruyama, Risako Mikami, Keiji Komatsu, Kenji Kikuchi, Kunimoto Hotta, Toshikazu Yoshikawa, Kouetsu Ogasawara, Atsuhiko Hattori, Shinichi Arakawa   +9 more
doaj   +2 more sources

Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies

International Journal of Molecular Sciences, 2022
This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative ...
Celia María Curieses Andrés, J. M. Pérez de la Lastra, Celia Andrés Juan, F. Plou, Eduardo Perez‐Lebeña   +4 more
semanticscholar   +1 more source

Research Progress of Small Molecule Fluorescent Probes for Detecting Hypochlorite

Sensors, 2021
Hypochlorous acid (HOCl) generates from the reaction between hydrogen peroxide and chloride ions via myeloperoxidase (MPO)-mediated in vivo. As very important reactive oxygen species (ROS), hypochlorous acid (HOCl)/hypochlorite (OCl−) play a crucial role
Zhi-Guo Song, Qing Yuan, Pengcheng Lv, Kun Chen   +3 more
doaj   +1 more source

Fluorescent probes for monitoring myeloperoxidase-derived hypochlorous acid: a comparative study

Scientific Reports, 2022
MPO-derived oxidants including HOCl contribute to tissue damage and the initiation and propagation of inflammatory diseases. The search for small molecule inhibitors of myeloperoxidase, as molecular tools and potential drugs, requires the application of ...
K. Pierzchala, Marlena Pięta, Monika Rola, M. Świerczyńska, Angelika Artelska, K. Dębowska, R. Podsiadły, Jakub Pięta, J. Zielonka, A. Sikora, A. Marcinek, R. Michalski   +11 more
semanticscholar   +1 more source

Time to rethink medical disinfection from a planetary health perspective

Journal of Global Health Reports, 2023
Disinfection products can have substantial environmental impacts which include associated manufacturing emissions, toxicity to marine life and potential adverse health outcomes. Despite this, disinfection is under-represented in sustainability approaches.
Kate M Homyer, Felicity V Mehendale
doaj   +1 more source

One-electron oxidation and reduction of glycosaminoglycan chloramides: a kinetic study. [PDF]

, 2013
Hypochlorous acid and its acid-base counterpart, hypochlorite ions, produced under inflammatory conditions, may produce chloramides of glycosaminoglycans, these being significant components of the extracellular matrix (ECM).
A.W.J. Paterson, Akeel, Al-Assaf, Al-Assaf, B.J. Parsons, Balazs, C. Houee-Levin, Camenisch, Chawla, D.J. Heyes, Dogliotti, Eriksen, Hardingham, Hawkins, Hayon, Hayon, Heckel, Heinecke, Huie, Ivanov, J.-L. Marignier, Jiang, Johnson, Kennett, Kennett, Kettle, Laurent, Laurent, McElroy, McElroy, McGowan, Milner, Misra, Parsons, Parsons, Pattison, Pattison, Pattison, Pe Myint, Poskrebyshev, Redpath, Rees, Rees, Rees, Rees, Rees, Rees, S. Sibanda, Schwarz, Stern, Swallow, Tang, Thomas, Thomas, Thorne, Toole, Toole, Toole, Turley, van Golen, von Sonntag, Weeks, Weiss, Weiss, Wine, Wolfenden, Woods, Zao   +67 more
core   +1 more source

Experimental study of the effects of hypochlorite on polysulfone membrane properties [PDF]

, 2006
Although chemical solutions are widely employed to clean membranes, they can also be responsible for changes in membrane properties. The two major drawbacks are then either the functional properties of the membrane gradually change, so the production can
Aimar, Pierre, Causserand, Christel, Rouaix, Sandrine   +2 more
core   +1 more source

Permeability and chemical analysis of aromatic polyamide based membranes exposed to sodium hypochlorite [PDF]

, 2011
In this study, a cross-linked aromatic polyamide based reverse osmosis membrane was exposed to variable sodium hypochlorite ageing conditions (free chlorine concentration, solution pH) and the resulting evolutions of membrane surface chemical and ...
Aimar, Pierre, Causserand, Christel, Ettori, Axel, Gaudichet-Maurin, Emmanuelle, Schrotter, Jean-Christophe   +4 more
core   +1 more source