Results 191 to 200 of about 14,051 (235)
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Hypochlorous acid mobilizes cellular zinc
Canadian Journal of Physiology and Pharmacology, 1991Neutrophil oxidants, in particular hypochlorous acid (HOCl), can cause injury to healthy tissues at sites of inflammation. Some of this injury may be caused by oxidant-induced mobilization of metals. We examined the ability of HOCl to mobilize Zn2+ in target tissues.
H, Fliss, M, Ménard, M, Desai
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Biomarkers of myeloperoxidase-derived hypochlorous acid
Free Radical Biology and Medicine, 2000Hypochlorous acid is the major strong oxidant generated by neutrophils. The heme enzyme myeloperoxidase catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride. Although myeloperoxidase has been implicated in the tissue damage that occurs in numerous diseases that involve inflammatory cells, it has proven difficult to ...
C C, Winterbourn, A J, Kettle
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Reaction of uracil with hypochlorous acid
Biochemical and Biophysical Research Communications, 1978Abstract The end products of the reaction of uracil with at least a 10-fold excess of aqueous hypochlorous acid at pH 7–8 were found to be trichloroacetic acid, carbon dioxide and nitrogen trichloride. Little formation of trichloroacetic acid was observed after 24 hours when the ratio of hypochlorous acid to uracil was less than 4:1.
W H, Dennis, V P, Olivieri, C W, Krusé
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Wound cleansing: benefits of hypochlorous acid
Journal of Wound Care, 2020Cleansing provides an opportunity to remove pathogens from the wound bed, thereby preventing an increase in the bioburden and delayed healing.
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Immunoglobulin cleavage by hypochlorous acid treatment
Clinica Chimica Acta, 1995IgA, IgG and IgM were cleaved by hypochlorous acid treatment. The apparent calculated molecular masses of three polypeptides obtained from IgA were 81.1. 25.8 and 13.9 kDa. The amounts of released IgA fragments were proportional to the amount of HOCl employed.
R, Drozdz, I, Guevara, J W, Naskalski
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Mechanism of cyanocobalamin chlorination by hypochlorous acid
JBIC Journal of Biological Inorganic Chemistry, 2021Hypochlorous acid (HOCl) is a strong oxidant produced by myeloperoxidase. Previous work suggested that HOCl modifies the corrin ring of cobalamins to yield chlorinated species via mechanisms that are incompletely understood. Herein, we report a mechanistic study on the reaction between cyanocobalamin (CNCbl, vitamin B12) and HOCl.
Ilia A. Dereven’kov +5 more
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Modification of phosphatidylserine by hypochlorous acid
Chemistry and Physics of Lipids, 2009The binding of the heme enzyme myeloperoxidase to phosphatidylserine epitopes on the surface of non-vital polymorphonuclear leukocytes and other cells at inflammatory sites favours modifications of this phospholipid by myeloperoxidase products. As detected by MALDI-TOF mass spectrometry hypochlorous acid and the myeloperoxidase-hydrogen peroxide ...
Joerg, Flemmig +4 more
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Cephalosporins are scavengers of hypochlorous acid
Biochemical Pharmacology, 1995Potential scavenging properties of cephalosporins (i.e. cefamandole, cefotaxime and ceftriaxone) towards hypochlorous acid (HOCl) as well as the antibacterial activity of control and HOCl-reacted antibiotics were investigated. We found that these drugs, at therapeutically relevant concentrations, are indeed scavengers of HOCl, with ceftriaxone showing ...
LAPENNA, Domenico +6 more
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Hypochlorous acid scavenging capacity of garlic
Phytotherapy Research, 2007AbstractThe ability of the following aqueous garlic extracts to scavenge hypochlorous acid (HOCl) was studied: (a) unheated extract of raw garlic (RG), (b) heated extract of raw garlic (HRG), (c) extract of boiled garlic cloves (BG) and (d) extract of microwave‐treated garlic cloves (MG).
José, Pedraza-Chaverrí +2 more
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A spectroscopic probe for hypochlorous acid detection
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022A spectroscopic probe CMBT was synthesized and characterized. CMBT showed the specific recognition for HClO based on the turn-on blue fluorescence and naked-eye change from pink to colorless. NMR, IR, HRMS-ESI, and spectral analysis suggested that colorimetric and fluorescent change of CMBT to HClO originated from the conversion of CMBT to starting ...
Ning, An +3 more
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