Results 51 to 60 of about 6,740 (215)

Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies

Haematologica
Chimeric antigen receptor (CAR-) T cell therapy causes serious side effects including cytokine release syndrome (CRS). CRS-related coagulopathy is associated with hypofibrinogenemia that is thus far considered the result of disseminated intravascular ...
Markus Perl, Konstantin Herfeld, Dennis C. Harrer, Matthias Höpting, Marina Schweiger, Ulrich Sterz, Leonard Knödler, Susanne Heimerl, Leo Hansmann, Wolfgang Herr, Hendrik Poeck, Daniel Wolff, Matthias Edinger, Christina Hart, Matthias A. Fante   +14 more
doaj   +1 more source

Fatal Chronic Varicella‐Zoster Viral Infection in a Young Man With Chediak–Higashi Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Chediak–Higashi syndrome (CHS) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (HLH), which significantly worsens prognosis. We report
Albane Badet, Clément Pruvot, Zoé Manssens, Wadih Abou‐Chahla, Sébastien Buche   +4 more
wiley   +1 more source

Visceral leishmaniasis, hypertriglyceridemia and secondary hemophagocytic lymphohistiocytosis [PDF]

, 2016
Visceral leishmaniasis (VL), a protozoan disease, is 100 % fatal if left untreated. Anemia is common in VL which plays a role in expression of clinically overt VL disease.
Barberi, G., Cama, V., CASCIO, ANTONIO, COLOMBA, Claudia, DI CARLO, Paola, Famà, F., Iaria, C., SCARLATA, Francesco   +7 more
core   +2 more sources

The impact of rapid infusers on the hemostatic potential of cryoprecipitate products

Transfusion, EarlyView.
Abstract Background In cases of massive transfusion, intravenous access can be limited. Additionally, delivering different products through separate lines and infusion methods adds unnecessary steps. RBC, plasma, and whole blood (WB) are delivered via rapid infusers; cryoprecipitate (CRYO) is infused through separate access and is not approved with ...
Connor D. Purvis, Samantha Redden, Andrew Jacobson, Yao‐Wei Wang, Julie Campbell, Jessica Cardenas, Jan‐Michael Van Gent, Bryan A. Cotton   +7 more
wiley   +1 more source

Elevating the standards of hypofibrinogenemia in trauma: Higher thresholds of admission fibrinogen predict mortality and organ dysfunction

Transfusion, EarlyView.
Abstract Background The precise thresholds at which admission fibrinogen predicts mortality and organ dysfunction in trauma patients are unknown. Study Design and Methods Retrospective study at a single trauma center. Inclusion criteria: 18–89 years, traumatic mechanism, transported from scene, and fibrinogen obtained within 30‐min of arrival ...
Justin Richards, Joseph Kufera, Mary Burgoyne, Deborah Stein, Rosemary Kozar   +4 more
wiley   +1 more source

Pediatric Therapeutic Plasma Exchange: Characterization of Practice, Epidemiology, and Safety Profile at a Children's Hospital in the United States

Journal of Clinical Apheresis, Volume 41, Issue 3, June 2026.
ABSTRACT There is a need to better understand the indications and safety profiles for therapeutic plasma exchange (TPE) in children. We aimed to assess pediatric TPE practice at a large academic center by retrospective chart review from 2011 to 2022. Patient demographics and clinical information including American Society for Apheresis (ASFA) category ...
Benjamin C. Lee, Brian D. Adkins, Ayda Javanbakht, Hung S. Luu, Daniel K. Noland   +4 more
wiley   +1 more source

Risk factors for poor outcomes of children with acute acalculous cholecystitis [PDF]

, 2017
BACKGROUND: Acute acalculous cholecystitis (AAC) is generally considered to be a mild disease in children; however, if left untreated or treated without caution, AAC can lead to severe outcomes, such as death. The objectives of this study were to present
Barie, Cheng-Hsun Chiu, Chien-Chang Chen, Chirdan, Elwood, Gora-Gebka, Han-I Wang, Hsun-Chin Chao, Huang, Huffman, Iaria, Imamoğlu, Imhof, Indar, Khan, Kuzu, Man-Shan Kong, Mateos-Corral, McChesney, McDonald, Pelinka, Prassouli, Rescorla, Ryu, Souza, Tsakayannis, Unal, Wang, Wang, Wiboltt, Yi-An Lu, Yokoe   +31 more
core   +2 more sources

Neonatal Hemophagocytic Lymphohistiocytosis – Case Report [PDF]

, 2010
Hemophagocytic lymphohystiocytosis (HLH) represents a severe hyperinflammatory condition with the cardinal symptoms prolonged fever, hepatosplenomegaly, and cytopenias. The most prominent histopathological feature of HLH is an accumulation of activated T
Barbara Kvenić, Ika Kardum-Skelin, Irena Seili-Bekafigo, Jelena Roganović, Nives Jonjić   +4 more
core   +1 more source

Fulminant hemophagocytic lymphohistiocytosis induced by pandemic A (H1N1) influenza: a case report [PDF]

, 2011
Introduction Hemophagocytic lymphohistiocytosis induced by viral diseases is a well recognized entity. Severe forms of H5N1 influenza are known to be associated with symptoms very similar to a reactive hemophagocytic syndrome.
Christophe Willekens, Aurélie Cornelius, Mary-Jane Guerry, Agnès Wacrenier, François Fourrier   +4 more
core   +1 more source

Severe Adult HLH/MAS With SPTCL‐Like Panniculitis: A Phenotype‐Guided, Resource‐Adapted Therapeutic Strategy Without Cytotoxic Therapy

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Graphical abstract illustrating the phenotype‐guided therapeutic approach in severe adult HLH/MAS with SPTCL‐like panniculitis, demonstrating clinical and biochemical response following sequential treatment with therapeutic plasma exchange, intravenous immunoglobulin, and cyclosporine.
Hatem Mousa Taha, Omar Marouf, Khaled Hatem Taha   +2 more
wiley   +1 more source