Results 61 to 70 of about 5,300 (203)

Hypofibrinogenemia Presenting as Intracranial Hemorrhage [PDF]

, 2015
Introduction: Factor I deficiency or fibrinogen deficiency, is a rare inherited bleeding disorder related to fibrinogen function in the blood coagulation cascade.
Sudulagunta, Sreenivasa rao, Khorram, Hadi, Sodalagunta, Mahesh Babu, Sepehrar, Mona, Aheta Sham, Mohammed, Noroozpour, Zahra   +5 more
core  

Peri‐operative management of multiple tooth extractions in a patient with congenital hypofibrinogenemia receiving anticoagulant therapy [PDF]

, 2021
Congenital fibrinogen disorder is rare and is responsible for the difficulty in achieving hemostasis following surgery. A 75-year-old man was referred to our hospital for the management of gingival hemorrhage.
Horikawa, Masaaki, Kasahara, Kazue, Kazue Kasahara, Masaaki Horikawa, Yoshiyuki Nakamichi, Wataru Kakuguchi, Ohiro, Yoichi, Yoichi Ohiro, Kakuguchi, Wataru, Nakamichi, Yoshiyuki   +9 more
core   +1 more source

Management of Kaposiform Haemangioendothelioma—A Retrospective Case Series Examining the Use and Effectiveness of Vincristine

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim Kaposiform haemangioendothelioma is a rare vascular tumour. Management has evolved over the last two decades, with most cases receiving vincristine or sirolimus. We aim to describe our experience with managing this tumour, with a focus on the safety and efficacy of vincristine.
Bronwen Kirk, Susan Adams, Orli Wargon, Artiene Tatian, Susan Russell   +4 more
wiley   +1 more source

Hepatic fibrinogen storage disease due to the fibrinogen γ375 Arg → Trp mutation "fibrinogen aguadilla" is present in Arabs

The Saudi Journal of Gastroenterology, 2014
The mutation γ375Arg → Trp (fibrinogen Aguadilla) is one of four mutations (Brescia, Aguadilla, Angers, and AI duPont) capable of causing hepatic storage of fibrinogen.
Abdulrahman Al-Hussaini, Abdulhadi Altalhi, Imad El Hag, Hussa AlHussaini, Paola Francalanci, Isabella Giovannoni, Francesco Callea   +6 more
doaj   +1 more source

The clinical use of cryoprecipitate and fibrinogen concentrate: A scoping review

Transfusion, EarlyView.
Abstract Background Acquired hypofibrinogenemia poses significant bleeding risks. Concentrated sources of fibrinogen, whether cryoprecipitate or fibrinogen concentrates, are widely used. This scoping review aimed to identify and map the available evidence on fibrinogen supplementation.
Aaron S. Hess, Sandra K. White, Elizabeth P. Crowe, Jay S. Raval, Jennifer Andrews, Claudia S. Cohn, Mischa L. Covington, Melissa M. Cushing, Cyril Jacquot, Jenna Khan, Anil K. Panigrahi, Nabiha H. Saifee, Aaron A. R. Tobian, Mary M. McFarland, Simon J. Stanworth, Ryan A. Metcalf   +15 more
wiley   +1 more source

Adeno‐Associated Virus Gene Therapy for Spinal Muscular Atrophy Induces Hepatotoxicity via Cytokine and Macrophage Activation

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatotoxicity is a common and significant adverse effect associated with adeno‐associated virus (AAV) gene therapy; however, the underlying mechanisms remain unknown. In this study, we demonstrated innate immune activation in two patients with spinal muscular atrophy shortly after receiving AAV9 gene therapy with onasemnogene abeparvovec ...
Aiko Sakai, Masaya Sugiyama, Masafumi Onodera, Fujiko Fukushima, Mai Tanaka, Toru Uchiyama, Masashi Mizokami, Ryo Sumazaki   +7 more
wiley   +1 more source

In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A > G causing abnormal RNA splicing [PDF]

, 2010
ArticleClinica Chimica Acta.
Kumagai, T, Honda, T, Terasawa, F, Fujihara, N, Kamijyo, Y, Yamauchi, K, Okumura, N, Shigematsu, S   +7 more
core   +1 more source

Severe Pediatric Snakebite With Coagulopathy and Compartment Syndrome: Conservative Management With Plasma Exchange

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Therapeutic plasma exchange was successfully used in a child with severe snakebite envenomation complicated by refractory venom‐induced consumptive coagulopathy and suspected compartment syndrome, leading to full recovery and avoidance of surgical intervention.
Zain Mohammed Al Muqbel, Abdulrahman Al‐Majmuei, Ali Haider Ali, Naseem Yusuf Fahad, Reema Ajjawi, Amal Al Dailami, Afshan Lone, Manal Al Maskati, Nasser Mohamed Mansoor   +8 more
wiley   +1 more source

Hyperfibrinolysis and hypofibrinogenemia diagnosed with rotational thromboelastometry in dogs naturally infected with angiostrongylus vasorum [PDF]

, 2017
BACKGROUND: The pathomechanism of Angiostrongylus vasorum infection-associated bleeding diathesis in dogs is not fully understood. OBJECTIVE: To describe rotational thromboelastometry (ROTEM) parameters in dogs naturally infected with A.
Kuemmerle-Fraune, C, Jud Schefer, Rahel, Kutter, Annette P N; https://orcid.org/, Sigrist, Nadja; https://orcid.org/, Schnyder, Manuela, Hofer-Inteeworn, Nathalie   +5 more
core   +1 more source

The thrombotic paradox in congenital fibrinogen deficiencies: from pathophysiology to practice

Research and Practice in Thrombosis and Haemostasis
Congenital fibrinogen deficiencies (CFDs) comprise rare inherited disorders characterized by quantitative (afibrinogenemia, hypofibrinogenemia) or qualitative (dysfibrinogenemia, hypodysfibrinogenemia) abnormalities of fibrinogen.
Samin Mohsenian, Alessandro Casini, Flora Peyvandi   +2 more
doaj   +1 more source