Results 81 to 90 of about 5,300 (203)

Fibrinogen Concentrate for the Treatment of Thrombolysis-Associated Hemorrhage in Adult Ischemic Stroke Patients

Clinical and Applied Thrombosis/Hemostasis, 2020
In patients with ischemic stroke who receive systemic recombinant tissue plasminogen activator (rt-PA), the risk of secondary hemorrhage is 1-7%. Fibrinogen supplementation with cryoprecipitate is recommended in patients with rt-PA-associated symptomatic
Megan E. Barra PharmD, BCPS, BCCCP, Steven K. Feske MD, Katelyn W. Sylvester PharmD, BCPS, Charlene Ong MD, MPHS, Sarah E. Culbreth PharmD, BCPS, Patricia Krause PharmD, BCPS, Galen V. Henderson MD, Eva Rybak PharmD, BCPS   +7 more
doaj   +1 more source

A new global fibrinolysis capacity assay for the sensitive detection of hyperfibrinolysis and hypofibrinogenemia in trauma patients.

, 2023
BACKGROUND: Conventional clotting tests are not expeditious enough to allow timely targeted interventions in trauma, and current point-of-care analyzers, such as rotational thromboelastometry (ROTEM), have limited sensitivity for hyperfibrinolysis and ...
Platton, S, Paul Vulliamy, Vulliamy, P, Davenport, R, Tracy Torres, Sean Platton, Rossetto, A, Curry, N, Nicola Curry, Ross Davenport, Torres, T, Andrea Rossetto   +11 more
core   +1 more source

Thrombotic and Hemorrhagic Complications in the Treatment of Acute Lymphoblastic Leukemia with L-Asparaginase

Клиническая онкогематология, 2018
The article provides a literature review on the use of the L-asparaginase (ASP) in acute lymphoblastic leukemia (ALL) and describes two clinical cases.
Gennadii Martinovich Galstyan, O. A. Polevodova, A. V. Bazhenov, V. V. Troitskaya, O. A. Gavrilina, D. G. Gitel’zon, A. E. Vasil’ev, E. N. Parovichnikova   +7 more
doaj   +1 more source

Protein S deficiency present in a pregnant woman with dyspnea, abdominal pains, restlessness, agitation and hypofibrinogenemia [PDF]

, 2015
Key Clinical Message: Hypofibrinogenemia is rare in pulmonary thromboembolism. A pregnant woman with dyspnea, abdominal pain, restlessness, agitation and protein S deficiency exhibited normal blood oxygenation and high D-dimer (370 mu g/mL) and ...
Umazume, Takeshi, Akaishi, Rina, Minakami, Hisanori, Takeshi Umazume, Rina Akaishi, Takahiro Yamada, Takahiro Koyama, Hisanori Minakami, Yamada, Takahiro, Koyama, Takahiro, Morikawa, Mamoru, Mamoru Morikawa   +11 more
core   +1 more source

Diagnosing and Managing Paradoxical Deep Vein Thrombosis in a Patient With Congenital Afibrinogenemia

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Congenital afibrinogenemia, classically a bleeding disorder, can paradoxically predispose to thrombosis, potentially due to disruptions in fibrin‐mediated thrombin clearance and plasmin activation. A young man with reported congenital afibrinogenemia presented with extensive deep vein thrombosis in the setting of undetectable fibrinogen and ...
Altamash Jawadi, Malik Alqawasmi, Mahmoud Abdelsamia, Hemza Assed, Mohammad Adawee, Mohammad Badawy, Xuan Thuy T. Nguyen, Andres E. Mindiola Romero, Allison Burnett, Ala Ebaid   +9 more
wiley   +1 more source

Efficacy and safety of fibrinogen administration in acute post-traumatic hypofibrinogenemia in isolated severe traumatic brain injury: A randomized clinical trial

, 2022
Aim: This study was conducted to evaluate clinical outcomes after fibrinogen administration in hypofibrinogenemia following severe traumatic brain injury.
Mahdavi, S. B., Shafiei, E., Sabouri, M., Vahidian, M., Sourani, A., Tehrani, D. S.   +5 more
core   +1 more source

Fibrinogen deficiency in a dog - a case report

BMC Veterinary Research, 2017
Background Among coagulation disorders, primary fibrinogen deficiency is very rare in dogs. It is divided into hypofibrinogenemia, afibrinogenemia and dysfibrinogenemia. Afibrinogenemia has been described in three dogs.
Franck Jolivet, Armelle Diquélou, Catherine Trumel, Simon Privat, Olivier Dossin   +4 more
doaj   +1 more source

Hepatic fibrinogen storage disease and hypofibrinogenemia caused by fibrinogen Aguadilla mutation: a case report

Journal of International Medical Research, 2020
Hepatic fibrinogen storage disease is a rare autosomal dominant genetic disorder characterized by hypofibrinogenemia, as well as the retention of variant fibrinogen within the hepatocellular endoplasmic reticulum. Here, we describe an asymptomatic 4-year-
Leilei Gu, Bin Wang, Lu Liu, Qiaorong Gan, Xiaolong Liu, Lihong Chen, Li Chen   +6 more
doaj   +1 more source

Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Sorafenib attenuates urethral scar formation by inhibiting β‐catenin signaling in fibroblasts, which downregulates the SLC7A11/GPX4 antioxidant axis and triggers ferroptosis. This β‐catenin–ferroptosis coupling effectively suppresses fibrogenesis, highlighting sorafenib as a promising drug‐repurposing candidate for urethral stricture.
Zhongying Yu, Xianzhong Zhu, Shijie Tang, Shubo Yang, Jinyu Li, Lianzhong Luo, Yan Tan, Jun Yin   +7 more
wiley   +1 more source

Fibrinogen Columbus: a novel gamma Gly200Val mutation causing hypofibrinogenemia in a family with associated thrombophilia

Haematologica, 2007
Fibrinogen is an essential component of the coagulation cascade and the acute phase response. The native 340 kDa molecule has a symmetrical trinodular structure composed of a central E-domain connected to outer D-domains by triple helical coiled-coils.1 ...
Ryan L. Davis, Michael W. Mosesson, Bryce A. Kerlin, Jason A. Canner, Frederick B. Ruymann, Stephen O. Brennan   +5 more
doaj   +1 more source