Results 71 to 80 of about 1,069 (160)

Total knee arthroplasty in a patient with hypofibrinogenemia [PDF]

, 2016
Patients with afibrinogenemia or hypofibrinogenemia present a unique challenge to the arthroplasty surgeon as fibrinogen is a key contributor to hemostasis.
Rubin, Lee E., Lee E. Rubin, MD, Truntzer, Jeremy N., Kalpit N. Shah, MD, Nacca, Christopher R., Christopher R. Nacca, MD, Shah, Kalpit N., Jeremy N. Truntzer, MD   +7 more
core   +1 more source

Adeno‐Associated Virus Gene Therapy for Spinal Muscular Atrophy Induces Hepatotoxicity via Cytokine and Macrophage Activation

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatotoxicity is a common and significant adverse effect associated with adeno‐associated virus (AAV) gene therapy; however, the underlying mechanisms remain unknown. In this study, we demonstrated innate immune activation in two patients with spinal muscular atrophy shortly after receiving AAV9 gene therapy with onasemnogene abeparvovec ...
Aiko Sakai, Masaya Sugiyama, Masafumi Onodera, Fujiko Fukushima, Mai Tanaka, Toru Uchiyama, Masashi Mizokami, Ryo Sumazaki   +7 more
wiley   +1 more source

In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A > G causing abnormal RNA splicing [PDF]

, 2010
ArticleClinica Chimica Acta.
Kumagai, T, Honda, T, Terasawa, F, Fujihara, N, Kamijyo, Y, Yamauchi, K, Okumura, N, Shigematsu, S   +7 more
core   +1 more source

Fibrinogen Concentrate for the Treatment of Thrombolysis-Associated Hemorrhage in Adult Ischemic Stroke Patients

Clinical and Applied Thrombosis/Hemostasis, 2020
In patients with ischemic stroke who receive systemic recombinant tissue plasminogen activator (rt-PA), the risk of secondary hemorrhage is 1-7%. Fibrinogen supplementation with cryoprecipitate is recommended in patients with rt-PA-associated symptomatic
Megan E. Barra PharmD, BCPS, BCCCP, Steven K. Feske MD, Katelyn W. Sylvester PharmD, BCPS, Charlene Ong MD, MPHS, Sarah E. Culbreth PharmD, BCPS, Patricia Krause PharmD, BCPS, Galen V. Henderson MD, Eva Rybak PharmD, BCPS   +7 more
doaj   +1 more source

Protein S deficiency present in a pregnant woman with dyspnea, abdominal pains, restlessness, agitation and hypofibrinogenemia [PDF]

, 2015
Key Clinical Message: Hypofibrinogenemia is rare in pulmonary thromboembolism. A pregnant woman with dyspnea, abdominal pain, restlessness, agitation and protein S deficiency exhibited normal blood oxygenation and high D-dimer (370 mu g/mL) and ...
Umazume, Takeshi, Akaishi, Rina, Minakami, Hisanori, Takeshi Umazume, Rina Akaishi, Takahiro Yamada, Takahiro Koyama, Hisanori Minakami, Yamada, Takahiro, Koyama, Takahiro, Morikawa, Mamoru, Mamoru Morikawa   +11 more
core   +1 more source

Efficacy and safety of fibrinogen administration in acute post-traumatic hypofibrinogenemia in isolated severe traumatic brain injury: A randomized clinical trial

, 2022
Aim: This study was conducted to evaluate clinical outcomes after fibrinogen administration in hypofibrinogenemia following severe traumatic brain injury.
Mahdavi, S. B., Shafiei, E., Sabouri, M., Vahidian, M., Sourani, A., Tehrani, D. S.   +5 more
core   +1 more source

Chiari I Malformation and Intramedullary Hemorrhage in a Female Patient with Klippel Trenaunay Syndrome: A Rare Case Report Study [PDF]

International Journal of Caring Sciences
Chiari I Malformation and Intramedullary Hemorrhage in a Female Patient with Klippel Trenaunay Syndrome: A Rare Case Report ...
Kalliopi Magounaki, Emmanouil Kalafatis, Dimitris Stergiou, Maria Tzaki, Dionysios Vekios, Aggelos Papakalos and Ioannis Kyriazis   +5 more
doaj  

Identification of Risk Factors and Predictive Indicators for Tigecycline‐Associated Hypofibrinogenemia

Clinical and Translational Science
To investigate the prevalence, clinical manifestations, and risk factors of hypofibrinogenemia after tigecycline use, which can disrupt coagulation and potentially hinder antimicrobial therapy.
Xiaohui Liu, Xuefeng Yuan, Long Wen, Xin Tan, Qian Sui, Jiheng Liu   +5 more
doaj   +1 more source

Fibrinogen deficiency in a dog - a case report

BMC Veterinary Research, 2017
Background Among coagulation disorders, primary fibrinogen deficiency is very rare in dogs. It is divided into hypofibrinogenemia, afibrinogenemia and dysfibrinogenemia. Afibrinogenemia has been described in three dogs.
Franck Jolivet, Armelle Diquélou, Catherine Trumel, Simon Privat, Olivier Dossin   +4 more
doaj   +1 more source

Hepatic fibrinogen storage disease and hypofibrinogenemia caused by fibrinogen Aguadilla mutation: a case report

Journal of International Medical Research, 2020
Hepatic fibrinogen storage disease is a rare autosomal dominant genetic disorder characterized by hypofibrinogenemia, as well as the retention of variant fibrinogen within the hepatocellular endoplasmic reticulum. Here, we describe an asymptomatic 4-year-
Leilei Gu, Bin Wang, Lu Liu, Qiaorong Gan, Xiaolong Liu, Lihong Chen, Li Chen   +6 more
doaj   +1 more source