Results 31 to 40 of about 19,833 (230)

Is Rituximab-Associated Hypogammaglobulinemia Always Linked to B-Cell Depletion?

Children, 2022
We describe a case of a 3-year-old male toddler with a history of severe and refractory warm antibody autoimmune hemolytic anemia (w-AIHA) since early infancy and hypogammaglobulinemia persisting 20 months after rituximab administration (second-line ...
Anthie Damianaki, Marianna Tzanoudaki, Maria Kanariou, Emmanouil Liatsis, Alexandros Panos, Alexandra Soldatou, Lydia Kossiva   +6 more
doaj   +1 more source

Persistent hypogammaglobulinemia after rituximab therapy in pediatric patients, prevalence and clinical outcomes

Clinical Immunology Communications
Hypogammaglobulinemia is a known side effect of rituximab (RTX) in adults, but its prevalence and persistence in children remain underexplored. This retrospective cohort study at a tertiary care center examines the prevalence and clinical outcomes of ...
Susanna P.C. Höppener, Saskia R. Veldkamp, Mark C.H. de Groot, Saskia Haitjema, Julia Drylewicz, Jaap Jan Boelens, Caroline A. Lindemans, Joris van Montfrans, Annet van Royen-Kerkhof, Marc H.A. Jansen   +9 more
doaj   +1 more source

Resistant Widespread Facial Impetigo in a Healthy Infant with Atopic Dermatitis [PDF]

Journal of Clinical and Diagnostic Research, 2018
Atopic Dermatitis (AD) or eczema is a chronic and relapsing, itchy skin inflammatory condition in infancy and childhood. The diagnosis is based on pruritus and an eczematous dermatitis with typical presentation.
Seyed Hesamedin Nabavizadeh, Ali Fazel, Soheila Alyasin, Mohammad Bahadoram, Gholamreza Houshmand   +4 more
doaj   +1 more source

Case Report: Kidney Transplantation in a Patient With Acquired Agammaglobulinemia and SLE. Issues and Challenges

Frontiers in Medicine, 2021
Lupus nephritis in the context of Systemic Lupus Erythematosus (SLE) is characterized by an unpredicted course with remissions and flare-ups. Among others, it remains a significant cause of end-stage kidney disease (ESKD) in relatively young patients ...
Paraskevi Pavlakou, Marios Papasotiriou, Theodoros Ntrinias, Alexandra Kourakli, Adamantia Bratsiakou, Dimitrios S. Goumenos, Evangelos Papachristou   +6 more
doaj   +1 more source

Vulnerability to Meningococcal Disease in Immunodeficiency Due to a Novel Pathogenic Missense Variant in NFKB1

Frontiers in Immunology, 2021
NF-κB1 deficiency is suggested to be the most common cause of common variable immunodeficiency (CVID). NFKB1 encodes for the p105 precursor protein of NF-κB1, which is converted into the active transcriptional subunit p50 through proteasomal processing ...
Manfred Anim, Manfred Anim, Georgios Sogkas, Georgios Sogkas, Gunnar Schmidt, Natalia Dubrowinskaja, Torsten Witte, Reinhold Ernst Schmidt, Reinhold Ernst Schmidt, Faranaz Atschekzei, Faranaz Atschekzei   +10 more
doaj   +1 more source

Subcutaneous Immunoglobulin Replacement Therapy with Hizentra® is Safe and Effective in Children Less Than 5 Years of Age. [PDF]

, 2015
BACKGROUND:Hizentra® (IGSC 20%) is a 20% liquid IgG product approved for subcutaneous administration in adults and children 2 years of age and older who have primary immunodeficiency disease (PIDD). There is limited information about the use of IGSC 20 %
Atkinson, Thomas Prescott, Bonilla, Francisco A, Dorsey, Morna, Gallagher, Joel L, Haddad, Elie, Heimall, Jennifer, Kobrynski, Lisa, Morris, David, Ochs, Hans D, Patel, Niraj C, Wahlstrom, Justin   +10 more
core   +2 more sources

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Monoclonal gammopathy in WHIM syndrome can mask hypogammaglobulinemia

Journal of Allergy and Clinical Immunology: Global
Monoclonal gammopathy can be seen at an early age in patients with warts-hypogammaglobulinemia, infections, and myelokathexis syndrome and can mask the presence of hypogammaglobulinemia.
Julia Lew, MD, Adil Adatia, MD
doaj   +1 more source

Immunoglobulin G: A useful outcome marker in the follow‐up of cystic fibrosis patients?

Immunity, Inflammation and Disease, 2021
Background and Methods Hypergammaglobulinemia (hyper‐IgG) and hypogammaglobulinemia (hypo‐IgG) have been reported in patients with cystic fibrosis (CF).
Laurence S. Hanssens, Sarah Cellauro, Jean Duchateau, Georges J. Casimir   +3 more
doaj   +1 more source