Results 21 to 30 of about 19,833 (230)

Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: two different conditions within the same disease spectrum

Haematologica, 2013
Patients with hypogammaglobulinemia who do not fulfill all the classical diagnostic criteria for common variable immunodeficiency (reduction of two immunoglobulin isotypes and a reduced response to vaccination) constitute a diagnostic and therapeutic ...
Gertjan J. Driessen, Virgil A.S.H. Dalm, P. Martin van Hagen, H. Anne Grashoff, Nico G. Hartwig, Annemarie M. C. van Rossum, Adilia Warris, Esther de Vries, Barbara H. Barendregt, Ingrid Pico, Sandra Posthumus, Menno C. van Zelm, Jacques J.M. van Dongen, Mirjam van der Burg   +13 more
doaj   +1 more source

Common variable immunodeficiency disorder: a clinical case

Медицинская иммунология, 2021
Primary immunodeficiency is a rare congenital pathology associated with failure of immune system, manifested by disturbances of its functions. These defects lead to increased susceptibility of patients to various infectious agents, as well as the ...
E. A. Sobko, I. V. Demko, I. A. Soloveva, A. Yu. Kraposhina, N. V. Gordeeva, D. A. Anikin, N. S. Pronkina, O. P. Ischenko   +7 more
doaj   +1 more source

Successful treatment of rituximab-unresponsive elderly-onset neuromyelitis optica spectrum disorder and hypogammaglobulinemia with ofatumumab plus intravenous immunoglobulin therapy in a patient with mutant FCGR3A genotype: A case report

Frontiers in Immunology, 2022
BackgroundElderly-onset neuromyelitis optica spectrum disorder (NMOSD) is a rare entity that poses a therapeutic challenge. We report a case of elderly-onset NMOSD with mutant FCGR3A genotype who was successfully treated with ofatumumab after multiple ...
Weihe Zhang, Yujuan Jiao, Jinsong Jiao, Ming Jin, Dantao Peng   +4 more
doaj   +1 more source

IgA and IgG hypogammaglobulinemia in Waldenström’s macroglobulinemia

Haematologica, 2010
Background Hypogammaglobulinemia is common in Waldenström’s macroglobulinemia. The etiology of this finding remains unclear, but it has been speculated to be based on tumor-induced suppression of the ‘uninvolved’ immunoglobulin productionDesign and ...
Zachary R. Hunter, Robert J. Manning, Christine Hanzis, Bryan T. Ciccarelli, Leukothea Ioakimidis, Christopher J. Patterson, Megan C. Lewicki, Hsuiyi Tseng, Ping Gong, Xia Liu, Yangsheng Zhou, Guang Yang, Jenny Sun, Lian Xu, Patricia Sheehy, Massimo Morra, Steven P. Treon   +16 more
doaj   +1 more source

Impaired B-Cell Differentiation in a Patient With STAT1 Gain-of-Function Mutation

Frontiers in Immunology, 2020
Hypogammaglobulinemia is a rare complication of STAT1 gain-of-function (GOF) mutations. We report an adult patient diagnosed with hypogammaglobulinemia caused by B-cell depletion during the treatment of disseminated cryptococcosis.
Kazuki Nemoto, Toshinori Kawanami, Takayuki Hoshina, Masataka Ishimura, Kei Yamasaki, Satoshi Okada, Hirokazu Kanegane, Kazuhiro Yatera, Koichi Kusuhara   +8 more
doaj   +1 more source

Mulibrey nanism and immunological complications: a comprehensive case report and literature review

Frontiers in Immunology, 2023
IntroductionMulibrey nanism (MUL) is a rare disorder caused by TRIM37 gene variants characterized by growth failure, dysmorphic features, congestive heart failure (CHF), and an increased risk of Wilms’ tumor.
Andrea Gazzin, Andrea Gazzin, Francesca Pala, Marita Bosticardo, Julie Niemela, Jennifer Stoddard, Eleonora Biasin, Paola Quarello, Diana Carli, Diana Carli, Francesca Ferroni, Ottavia M. Delmonte, Davide Montin, Sergio D. Rosenzweig, Francesco Licciardi, Luigi D. Notarangelo   +15 more
doaj   +1 more source

In-depth blood immune profiling of Good syndrome patients

Frontiers in Immunology, 2023
IntroductionGood syndrome (GS) is a rare adult-onset immunodeficiency first described in 1954. It is characterized by the coexistence of a thymoma and hypogammaglobulinemia, associated with an increased susceptibility to infections and autoimmunity.
Alba Torres-Valle, Alba Torres-Valle, Alba Torres-Valle, Larraitz Aragon, Susana L. Silva, Susana L. Silva, Cristina Serrano, Miguel Marcos, Miguel Marcos, Miguel Marcos, Josefa Melero, Carolien Bonroy, Carolien Bonroy, Pedro Pablo Arenas-Caro, David Monzon Casado, Pedro Mikel Requejo Olaizola, Jana Neirinck, Jana Neirinck, Mattias Hofmans, Mattias Hofmans, Sonia de Arriba, María Jara, María Jara, María Jara, Carlos Prieto, Ana E. Sousa, Álvaro Prada, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Martín Pérez-Andrés, Martín Pérez-Andrés, Martín Pérez-Andrés, Martín Pérez-Andrés, Alberto Orfao, Alberto Orfao, Alberto Orfao, Alberto Orfao   +37 more
doaj   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Evaluation of humoral immunity profiles to identify heart recipients at risk for development of severe infections: a multicenter prospective study [PDF]

, 2017
[Abstract] BACKGROUND: New biomarkers are necessary to improve detection of the risk of infection in heart transplantation. We performed a multicenter study to evaluate humoral immunity profiles that could better enable us to identify heart recipients at
Almenar-Bonet, Luis, Calahorra, Leticia, Carbone, Javier, Cebrián, Mónica, Crespo-Leiro, María Generosa, Fernández-Cruz, Eduardo, Fernández-Yáñez, Juan, Gómez-Bueno, Manuel, Gómez-Sánchez, Miguel, Jaramillo, María, Levy, Beltrán, López, Javier, Mirabet, Sonia, Navarro, Joaquín, Paniagua-Martín, María J., Rodríguez-Molina, Juan José, Rábago, Gregorio, Sarmiento, Elizabeth, Segovia-Cubero, Javier   +18 more
core   +2 more sources

A computational pipeline for the diagnosis of CVID patients [PDF]

, 2019
Common variable immunodeficiency (CVID) is one of the most frequently diagnosed primary antibody deficiencies (PADs), a group of disorders characterized by a decrease in one or more immunoglobulin (sub) classes and/or impaired antibody responses caused ...
Bogaert, Delfien, Dullaers, Melissa, Emmaneel, Annelies, Haerynck, Filomeen, Saeys, Yvan, Tavernier, Simon, Van Gassen, Sofie   +6 more
core   +2 more sources