Results 81 to 90 of about 19,540 (227)

Mutations of Bruton's tyrosine kinase gene in Brazilian patients with X-linked agammaglobulinemia [PDF]

, 2010
Mutations in Bruton's tyrosine kinase (BTK) gene are responsible for X-linked agammaglobulinemia (XLA), which is characterized by recurrent bacterial infections, profound hypogammaglobulinemia, and decreased numbers of mature B cells in peripheral blood.
OLIVEIRA JÚNIOR, E.B., RAMALHO, V.D., ROXO JÚNIOR, P., TANI, S.M., VILELA, M.M.S.   +4 more
core   +2 more sources

Steroid‐Refractory Cryptogenic Organising Pneumonia (COP) in a Patient With Mannose‐Binding Lectin (MBL) Deficiency

Respirology Case Reports, Volume 14, Issue 2, February 2026.
A 67‐year‐old man with cryptogenic organising pneumonia developed recurrent relapses despite corticosteroid and mycophenolate therapy. A complete absence of mannose‐binding lectin was identified, suggesting impaired apoptotic cell clearance as a contributor to persistent inflammation.
Ilias E. Dimeas, Sotirios I. Sinis, Paraskevi Kirgou, Cormac McCarthy, Zoe Daniil   +4 more
wiley   +1 more source

Case Report—Secondary Antibody Deficiency Due to Endogenous Hypercortisolism

Frontiers in Immunology, 2020
Therapeutic corticosteroids have an immunosuppressive function involving several pathways, including lymphocytopenia and hypogammaglobulinemia. While these effects have been well-described in patients that received corticosteroids for therapeutic reasons,
Jelena Sarcevic, Claudia Cavelti-Weder, Christoph T. Berger, Christoph T. Berger, Marten Trendelenburg, Marten Trendelenburg   +5 more
doaj   +1 more source

Common variable immunodeficiency, impaired neurological development and reduced numbers of T regulatory cells in a 10-year-old boy with a STAT1 gain-of-function mutation [PDF]

, 2016
Recently, gain-of-function (GOF) mutations in the gene encoding signal transducer and activator of transcription 1 (STAT1) have been associated with chronic mucocutaneous candidiasis (CMC).
Fuchs, S, Grimbacher, B, Jenderny, J, Kobbe, R, Kochhan, L, Kolster, M, Meyer, T, Schulze-Sturm, U, Staab, J, Tolosa, E   +9 more
core   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

A rare case of alpha 1-antitrypsin deficiency associated with hypogammaglobulinemia and recurrent pulmonary thrombosis

Annals of Thoracic Medicine, 2014
Alpha 1-antitrypsin (AAT) belongs to the family of serpins (serine protease inhibitors). Loop sheet polymerization is the pathology behind serpinopathies which encompasses AAT, anti-thrombin III and neuroserpin deficiency.
Raghav Gupta, Srilekha Sridhara, John A Wood   +2 more
doaj   +1 more source

Ecthyma gangrenosum caused by Pseudomonas aeruginosa in a patient with astrocytoma treated with chemotherapy [PDF]

, 2010
Ecthyma gangrenosum, presenting as embolic lesions caused by Pseudomonas aeruginosa infection, has distinct pathognomonic features and a high mortality rate in patients with bacteremia, but when recognized early is easily treated.
Jonge, M.J.A. (Maja) de, Middelburg, T.A. (Tom), Seynaeve, C.M. (Caroline), Vos, F.Y.F.L. de   +3 more
core   +4 more sources

T‐Cell–Redirecting Immunotherapies in Relapsed/Refractory Mantle Cell Lymphoma: Current Evidence, Sequencing, and Future Directions

European Journal of Haematology, Volume 116, Issue 2, Page 129-141, February 2026.
ABSTRACT Relapsed/refractory (R/R) mantle cell lymphoma (MCL) remains a therapeutic challenge, particularly in patients with high‐risk features or prior exposure to Bruton's tyrosine kinase inhibitors (BTKis). The advent of T‐cell–redirecting immunotherapies, including chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies (BsAbs ...
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

Age, Low Immunoglobulin G, and M Serum Levels Predict Infections in People With AQP4‐IgG+ NMOSD Treated With Rituximab—A Multicenter Cohort Study From the German Neuromyelitis Optica Study Group (NEMOS)

European Journal of Neurology, Volume 33, Issue 2, February 2026.
In this multicenter cohort study, we evaluated the risk of infection in people with AQP4‐IgG+ NMOSD treated with rituximab. We found no significant difference in infection risk between patients receiving rituximab and those treated with azathioprine.
Daniel Engels, Mariella Herfurth, Joachim Havla, Patrick Schindler, Klemens Ruprecht, Carolin Schwake, Marius Ringelstein, Katinka Fischer, Charlotte Schubert, Insa Schiffmann, Martin W. Hümmert, Katrin Giglhuber, Sven Jarius, Ioannis Vardakas, Matthias Grothe, Thorleif Etgen, Clemens Warnke, Jasmin Naumann, Frank Hoffmann, Makbule Senel, Brigitte Wildemann, Achim Berthele, Corinna Trebst, Vivien Häußler, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann‐Strobl, Florian Then Bergh, Tania Kümpfel, Neuromyelitis Optica Study Group (NEMOS)   +29 more
wiley   +1 more source

Hypogammaglobulinemia and Poor Performance Status are Predisposing Factors for Vancomycin-Resistant Enterococcus Colonization in Patients with Hematological Malignancies

Turkish Journal of Hematology, 2017
Objective: Vancomycin-resistant enterococci (VRE) are common pathogens of hospital-acquired infection. Long hospitalization periods, use of broadspectrum antibiotics, and immunosuppression are major risks for VRE colonization.
Elif Gülsüm Ümit, Figen Kuloglu, Ahmet Muzaffer Demir   +2 more
doaj   +1 more source