Results 91 to 100 of about 158,302 (232)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Bioactive Polysaccharides Targeting Gut Microbiota to Modulate Host Health: A Gear Effect Theory

Food Frontiers, EarlyView.
The “Gear Effect” mechanism of bioactive polysaccharides driving gut microbiota to modulate host health. ABSTRACT Bioactive polysaccharides are macromolecular polymers with broad biological activities. Recent evidence has highlighted their role in modulating host health primarily through interactions with gut microbiota.
Yonggan Sun, Shanshan Zhang, Junyi Yin, Shaoping Nie   +3 more
wiley   +1 more source

The Postbiotic Potential of Microalgae

Food Frontiers, EarlyView.
Description of “Microalgal Postbiotic” following ISAPP Consensus (Salminen et al. 2021b) (Icons produced with Biorender) ABSTRACT The International Scientific Association for Probiotics and Prebiotics (ISAPP) has defined postbiotics as “preparations of inanimate microorganisms and/or their components that confer a health benefit on the host ...
Francesco Martelli, Caterina Nicolotti, Benedetta Bottari   +2 more
wiley   +1 more source

Exploring the bio‐functional potential of polysaccharides from Morchella esculenta: A mini review

Food Biomacromolecules, EarlyView.
Abstract Polysaccharides, natural polymers of monosaccharides, exhibit diverse biological activities due to their molecular structures and functional properties. Morchella esculenta, a precious edible mushroom with higher market value, is also rich in polysaccharides (MEP) and holds potential as a bioactive compound with therapeutic and functional food
Shiva Bakshi, Vinod Kumar Paswan
wiley   +1 more source

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source

Oligodendrogenesis in Evolution, Development and Adulthood

Glia, EarlyView.
Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu, Tianhao Gao, Jingwei Zhao, Huiliang Li   +3 more
wiley   +1 more source

Neonatal mortality risk for vulnerable newborn types in 15 countries using 125.5 million nationwide birth outcome records, 2000–2020

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView., 2023
Abstract Objective To compare neonatal mortality associated with six novel vulnerable newborn types in 125.5 million live births across 15 countries, 2000–2020. Design Population‐based, multi‐country study. Setting National data systems in 15 middle‐ and high‐income countries.
Lorena Suárez‐Idueta, Hannah Blencowe, Yemisrach B Okwaraji, Judith Yargawa, Ellen Bradley, Adrienne Gordon, Vicki Flenady, Enny S. Paixao, Mauricio L. Barreto, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jírová, Erzsebet Horváth‐Puhó, Henrik Toft Sørensen, Luule Sakkeus, Liili Abuladze, Khalid A. Yunis, Ayah Al Bizri, Arturo Barranco, Lisa Broeders, Aimée E. van Dijk, Fawziya Alyafei, Tawa O. Olukade, Neda Razaz, Jonas Söderling, Lucy K. Smith, Elizabeth S. Draper, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Eric O. Ohuma, Joy E. Lawn, the National Vulnerable Newborn Mortality Collaborative Group and Vulnerable Newborn Measurement Core Group, Kara Warrilow, Harriet Lawford, Arturo Barranco Flores, Jesus Felipe Gonzalez Roldan, Mai AlQubaisi, Tawa O. Olukade, Hamdy A. Ali, Bradley N. Manktelow, Ruth J. Matthews, Alan Fenton, Celina Davis, Bob Black, Joanne Katz, Dan Erchick, Elizabeth Hazel, Mike Diaz, Anne C. C. Lee   +53 more
wiley   +1 more source

Vulnerable newborn types: analysis of subnational, population‐based birth cohorts for 541 285 live births in 23 countries, 2000–2021

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView., 2023
Abstract Objective To examine prevalence of novel newborn types among 541 285 live births in 23 countries from 2000 to 2021. Design Descriptive multi‐country secondary data analysis. Setting Subnational, population‐based birth cohort studies (n = 45) in 23 low‐ and middle‐income countries (LMICs) spanning 2000–2021.
D. J. Erchick, E. A. Hazel, J. Katz, A. C. C. Lee, M. Diaz, L. S. F. Wu, S. Yoshida, R. Bahl, C. Grandi, A. B. Labrique, M. Rashid, S. Ahmed, A. D. Roy, R. Haque, S. Shaikh, A. H. Baqui, S. K. Saha, R. Khanam, S. Rahman, R. Shapiro, R. Zash, M. F. Silveira, R. Buffarini, P. Kolsteren, C. Lachat, L. Huybregts, D. Roberfroid, L. Zeng, Z. Zhu, J. He, X. Qiu, S. H. Gebreyesus, K. Tesfamariam, D. Bekele, G. Chan, E. Baye, F. Workneh, K. P. Asante, E. B. Kaali, S. Adu‐Afarwuah, K. G. Dewey, S. Gyaase, B. J. Wylie, B. R. Kirkwood, A. Manu, R. D. Thulasiraj, J. Tielsch, R. Chowdhury, S. Taneja, G. R. Babu, P. Shriyan, P. Ashorn, K. Maleta, U. Ashorn, C. Mangani, S. Acevedo‐Gallegos, M. J. Rodriguez‐Sibaja, S. K. Khatry, S. C. LeClerq, L. C. Mullany, F. Jehan, M. Ilyas, S. J. Rogerson, H. W. Unger, R. Ghosh, S. Musange, V. Ramokolo, W. Zembe‐Mkabile, M. Lazzerini, M. Rishard, D. Wang, W. W. Fawzi, D. T. R. Minja, C. Schmiegelow, H. Masanja, E. Smith, J. P. A. Lusingu, O. A. Msemo, F. M. Kabole, S. N. Slim, P. Keentupthai, A. Mongkolchati, R. Kajubi, A. Kakuru, P. Waiswa, D. Walker, D. H. Hamer, K. E. A. Semrau, E. B. Chaponda, R. M. Chico, B. Banda, K. Musokotwane, A. Manasyan, J. M. Pry, B. Chasekwa, J. Humphrey, R. E. Black, the Subnational Vulnerable Newborn Prevalence Collaborative Group and Vulnerable Newborn Measurement Core Group, Hasmot Ali, Parul Christian, Rolf D. W. Klemm, Alan B. Massie, Maithili Mitra, Sucheta Mehra, Kerry J. Schulze, Abu Ahmed Shamim, Alfred Sommer, MD. Barkat Ullah, Keith P. West, Nazma Begum, Nabidul Haque Chowdhury, Md. Shafiqul Islam, Dipak Kumar Mitra, Abdul Quaiyum, Modiegi Diseko, Joseph Makhema, Yue Cheng, Yixin Guo, Shanshan Yuan, Meselech Roro, Bilal Shikur, Frederick Goddard, Sebastien Haneuse, Bezawit Hunegnaw, Yemane Berhane, Alemayehu Worku, Seyram Kaali, Charles D. Arnold, Darby Jack, Seeba Amenga‐Etego, Lisa Hurt, Caitlin Shannon, Seyi Soremekun, Nita Bhandari, Jose Martines, Sarmila Mazumder, Yamuna Ana, R Deepa, Lotta Hallamaa, Juha Pyykkö, Mario I. Lumbreras‐Marquez, Claudia E. Mendoza‐Carrera, Atiya Hussain, Muhammad Karim, Farzana Kausar, Usma Mehmood, Naila Nadeem, Muhammad Imran Nisar, Muhammad Sajid, Ivo Mueller, Maria Ome‐Kaius, Elizabeth Butrick, Felix Sayinzoga, Ilaria Mariani, Willy Urassa, Thor Theander, Phillippe Deloron, Birgitte Bruun Nielsen, Alfa Muhihi, Ramadhani Abdallah Noor, Ib Bygbjerg, Sofie Lykke Moeller, Fahad Aftab, Said M. Ali, Pratibha Dhingra, Usha Dhingra, Arup Dutta, Sunil Sazawal, Atifa Suleiman, Mohammed Mohammed, Saikat Deb, Moses R. Kamya, Miriam Nakalembe, Jude Mulowooz, Nicole Santos, Godfrey Biemba, Julie M. Herlihy, Reuben K. Mbewe, Fern Mweena, Kojo Yeboah‐Antwi, Jane Bruce, Daniel Chandramohan, Andrew Prendergast, Joy E. Lawn, Hannah Blencowe, Eric Ohuma, Yemi Okwaraji, Judith Yargawa, Ellen Bradley, Joanne Katz   +189 more
wiley   +1 more source

Patient‐derived tumor organoids highlight the potential of precision medicine in managing pancreatic ductal adenocarcinoma

International Journal of Cancer, EarlyView.
What's New? Only about one‐fifth of patients with pancreatic ductal adenocarcinoma (PDAC) qualify for curative treatment approaches employing adjuvant chemotherapy. Tools to predict PDAC response to chemotherapeutic regimens, however, are lacking.
Christine Nitschke, Charline Phan, Yara Souto, Philipp Walter, Mara Goetz, Gediminas Simkus, Jacob Thastrup, Ronald Simon, Jürgen Kupper, Jakob Izbicki, Steven A. Johnsen, Thilo Hackert, Marianne Sinn, Harriet Wikman, Faik G. Uzunoglu, Tabea M. Sturmheit   +15 more
wiley   +1 more source

Neonatal mortality risk of large‐for‐gestational‐age and macrosomic live births in 15 countries, including 115.6 million nationwide linked records, 2000–2020

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView., 2023
Abstract Objective We aimed to compare the prevalence and neonatal mortality associated with large for gestational age (LGA) and macrosomia among 115.6 million live births in 15 countries, between 2000 and 2020. Design Population‐based, multi‐country study. Setting National healthcare systems. Population Liveborn infants.
Lorena Suárez‐Idueta, Eric O. Ohuma, Chia‐Jung Chang, Elizabeth A. Hazel, Judith Yargawa, Yemisrach B. Okwaraji, Ellen Bradley, Adrienne Gordon, Jessica Sexton, Harriet L. S. Lawford, Enny S. Paixao, Ila R. Falcão, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jírová, Erzsebet Horváth‐Puhó, Henrik T. Sørensen, Luule Sakkeus, Lili Abuladze, Khalid A. Yunis, Ayah Al Bizri, Sonia Lopez Alvarez, Lisa Broeders, Aimée E. van Dijk, Fawziya Alyafei, Mai AlQubaisi, Neda Razaz, Jonas Söderling, Lucy K. Smith, Ruth J. Matthews, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Joy E. Lawn, Hannah Blencowe, the National Vulnerable Newborn Mortality Collaborative Group and the Vulnerable Newborn Measurement Core Group, Vicki Flenady, Kara Warrilow, Harriet Lawford, Mauricio Lima Barreto, Ila Rocha Falcão, Erzsébet Horváth‐Puhó, Liili Abuladze, Pascale Nakad, Arturo Barranco Flores, Jesus Felipe Gonzalez Roldan, Fawzia Alyafei, Tawa O. Olukade, Hamdy A. Ali, Mohamad Rami Alturk, Bradley N. Manktelow, Elizabeth Draper, Alan Fenton, Jennifer J. Kurinczuk, Celina Davis, Samantha Clarke   +59 more
wiley   +1 more source