Results 91 to 100 of about 228,932 (402)

Decreased branched-chain amino acids and elevated fatty acids during antecedent hypoglycemia in type 1 diabetes

BMJ Open Diabetes Research & Care, 2023
Introduction Hypoglycemia is a major limiting factor in achieving recommended glycemic targets for people with type 1 diabetes. Exposure to recurrent hypoglycemia results in blunted hormonal counter-regulatory and symptomatic responses to hypoglycemia ...
Ulrik Pedersen-Bjergaard, Cristina Legido-Quigley, Rui She, Naba Hassan Al-sari, Ismo Matias Mattila, Anne-Sophie Sejling, Jens Pedersen   +6 more
doaj   +1 more source

A machine-learning approach to predict postprandial hypoglycemia

BMC Medical Informatics and Decision Making, 2019
BackgroundFor an effective artificial pancreas (AP) system and an improved therapeutic intervention with continuous glucose monitoring (CGM), predicting the occurrence of hypoglycemia accurately is very important.
Wonju Seo, You-Bin Lee, Seunghyun Lee, Sang-Man Jin, Sung-Min Park   +4 more
semanticscholar   +1 more source

Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery

Advanced Therapeutics, EarlyView.
Here, glycol chitosan (GC)‐coated PLGA NPs are developed to enhance oral drug delivery by enabling dual‐pathway endocytosis via clathrin‐ and caveolae‐mediated mechanisms. Alginate layering coating on GC‐PLGA further improves oral insulin delivery, achieving sustained glucose reduction in diabetic mice.
Huiwen Pang, Wenxuan Yu, Youzhi Wu, Xuqiang Nie, Guojun Huang, Zhi Ping Xu, Chen Chen, Felicity Y. Han   +7 more
wiley   +1 more source

Circulating differentiated and senescent lymphocyte subsets and incident diabetes risk in older adults: The Cardiovascular Health Study

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
This study performed a longitudinal analysis of a comprehensive panel of 22 innate and adaptive immune cell phenotypes, including differentiated and senescent CD4+ and CD8+ cells, with incident diabetes risk among a U.S. community‐based population of older adults.
Nels C. Olson, Margaret F. Doyle, Petra Buzkova, Sally A. Huber, Ian H. de Boer, Colleen M. Sitlani, Russell P. Tracy, Bruce M. Psaty, Kenneth J. Mukamal, Joseph A. Delaney   +9 more
wiley   +1 more source

Clustering of Hypoglycemia Events in Patients With Hyperinsulinism: Extension of the Digital Phenotype Through Retrospective Data Analysis

Journal of Medical Internet Research, 2021
BackgroundHyperinsulinism (HI) due to excess and dysregulated insulin secretion is the most common cause of severe and recurrent hypoglycemia in childhood.
Chris Worth, Simon Harper, Maria Salomon-Estebanez, Elaine O'Shea, Paul W Nutter, Mark J Dunne, Indraneel Banerjee   +6 more
doaj   +1 more source

Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence. [PDF]

, 2015
BackgroundWe hypothesize that depression in type 2 diabetes might be associated with poor glycemic control, in part due to suboptimal self-care. We tested this hypothesis by examining the associations of depression with clinical and laboratory findings ...
Chan, Juliana Cn, China Depression in Chinese Patients with Type 2 Diabetes (DD2) Study Group, Guo, Xiaohui, Ji, Linong, Jia, Weiping, Kong, Alice Ps, Li, Wenhui, Luk, Andrea Oy, Morisky, Donald E, Oldenburg, Brian, Sartorius, Norman, Ting, Rose Zw, Weng, Jianping, Wing, Yun-Kwok, Yang, Wenying, Zhang, Yuying   +15 more
core   +1 more source

Reducing the burden of hypoglycaemia in people with diabetes through increased understanding:design of the Hypoglycaemia Redefining Solutions for Better Lives (Hypo-RESOLVE) project [PDF]

, 2020
Background Hypoglycaemia is the most frequent complication of treatment with insulin or insulin secretagogues in people with diabetes. Severe hypoglycaemia, i.e.
Carlton, J., Choudhary, P., de Galan, B.E., Heller, S.R., Hypo-RESOLVE, C.o.n.s.o.r.t.i.u.m., Ibberson, M., McCrimmon, R.J., Mullenborn, M., Pieber, T.R., Pouwer, F., Rosilio, M., Speight, J., Tack, C.J.   +12 more
core   +4 more sources

Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes

Pediatric Diabetes, 2018
Fear of hypoglycemia is common in parents of young children with type 1 diabetes (T1D), but little is known about the specific fears that parents most often experience. Hypoglycemia fear has been associated with poorer glycemic control in older children,
M. V. Van Name, M. Hilliard, Claire T Boyle, K. Miller, D. Desalvo, B. Anderson, L. Laffel, Stephanie E. Woerner, L. Dimeglio, W. Tamborlane   +9 more
semanticscholar   +1 more source

On the Relentless Pursuit of an Oral Insulin Delivery System: How Far is Too Far?

Advanced Therapeutics, EarlyView.
Injectable insulin preparations have far outpaced oral ones by virtue of adequate bioavailability and are driven by innovations, including insulin pumps, real‐time blood glucose monitoring, and artificial intelligence. In contrast, oral insulin delivery systems, including nanomedicines, continue to struggle and lag due to varied reasons.
Sourav Bhattacharjee
wiley   +1 more source

Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason, Charles C. T. Hindmarch, Kimberly J. Dunham‐Snary   +2 more
wiley   +1 more source