Results 101 to 110 of about 228,932 (402)

Hypoglycemia in Mitochondrial Disorders [PDF]

, 2019
INTRODUCTION: The electron transport chain (ETC) in mitochondria functions to produce energy in the form of adenosine triphosphate (ATP). Defects in the mitochondrial or nuclear DNA that codes for components of the ETC lead to mitochondrial disorders ...
Moats, Allison
core   +1 more source

IMPAIRED AWARENESS OF HYPOGLYCEMIA CONTINUES TO BE A RISK FACTOR FOR SEVERE HYPOGLYCEMIA DESPITE THE USE OF CONTINUOUS GLUCOSE MONITORING SYSTEM IN TYPE 1 DIABETES.

Endocrine Practice, 2019
OBJECTIVE Impaired awareness of hypoglycemia (IAH) is a risk factor for severe hypoglycemia in patients with type 1 diabetes (T1D) not using Continuous Glucose Monitoring (CGM) system.
Yu Kuei Lin, Man Hung, Anu Sharma, O. Chan, M. Varner, Gitana Staskus, S. Fisher   +6 more
semanticscholar   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Comparison of Epilepsy Induced by Ischemic Hypoxic Brain Injury and Hypoglycemic Brain Injury using Multilevel Fusion of Data Features [PDF]

Fusion: Practice and Applications Volume 10 , Issue 1 , PP: 100-115, 2023
The study aims to investigate the similarities and differences in the brain damage caused by Hypoxia-Ischemia (HI), Hypoglycemia, and Epilepsy. Hypoglycemia poses a significant challenge in improving glycemic regulation for insulin-treated patients, while HI brain disease in neonates is associated with low oxygen levels.
arxiv   +1 more source

Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids. [PDF]

, 2019
Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines.
Abagyan, Ruben, Atayee, Rabia S, Makunts, Tigran, U, Andrew   +3 more
core   +1 more source

Comparison of insulin detemir and insulin glargine in a Basal-Bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: A 52-week, multinational, randomized, open-label, parallel-group, treat-to-target noninferiority trial [PDF]

, 2009
Objective: The primary study objective was to determine whether insulin detemir (detemir) was noninferior to insulin glargine (glargine) as the basal insulin in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in terms of glycemic ...
Albright, Bolli, Bruce Bode, Buse, Christoph Koenen, Devries, Garg, Havelund, Heinemann, Heinemann, Heise, Heise, Hermansen, Hougaard, Jehle, Klein, Le Floch, Montgomery, Owens, Pieber, Ratner, Russell-Jones, Simon Heller   +22 more
core   +1 more source

Hypoglycemia‐associated autonomic failure, counterregulatory responses, and therapeutic options in type 1 diabetes

Annals of the New York Academy of Sciences, 2019
Hypoglycemia remains a major barrier to the achievement of target levels of glycemic control for most individuals with insulin‐dependent type 1 diabetes (T1D).
M. Rickels
semanticscholar   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

Hypoglycemia in blood glucose level in type 2 diabetic Japanese patients by continuous glucose monitoring

Diabetology & Metabolic Syndrome, 2019
Background Hypoglycemia is associated with cardiovascular diseases, increased risk of death. Therefore, it is important to avoid hypoglycemia. The aim of this study was to characterize hypoglycemia according to glycated hemoglobin (HbA1c) level and ...
Maiko Hajime, Yosuke Okada, Hiroko Mori, Fumi Uemura, Satomi Sonoda, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto, Yoshiya Tanaka   +9 more
doaj   +1 more source

The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies

Critical Care, 2023
Background Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later.
Jan Gunst, Astrid De Bruyn, An Jacobs, Lies Langouche, Inge Derese, Karolijn Dulfer, Fabian Güiza, Gonzalo Garcia Guerra, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek, Greet Van den Berghe   +12 more
doaj   +1 more source