Results 121 to 130 of about 228,932 (402)
Advanced Science, EarlyView.This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou +9 more
wiley +1 more source
Basal-Bolus Advisor for Type 1 Diabetes (T1D) Patients Using Multi-Agent Reinforcement Learning (RL) Methodology [PDF]
arXiv, 2023 This paper presents a novel multi-agent reinforcement learning (RL) approach for personalized glucose control in individuals with type 1 diabetes (T1D). The method employs a closed-loop system consisting of a blood glucose (BG) metabolic model and a multi-agent soft actor-critic RL model acting as the basal-bolus advisor.
arxiv
Journal of Diabetes Science and Technology, 2019 Hypoglycemia remains the limiting factor of near-normal glucose control in people with diabetes using insulin therapy. Continuous glucose monitoring (CGM) may be able to avoid hypoglycemia and support the management of hypoglycemia problems in clinical ...
N. Hermanns +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.A multifunctional wound dressing (ACG gels) with antioxidant, local glycocontrol, and antibacterial properties to promote diabetic wound healing. Au‐CeO2 dumbbells effectively eliminate ROS, protecting cells from oxidative stress‐induced damage while exhibiting significant near‐infrared photothermal antibacterial activity.
Bangguo Zhou +9 more
wiley +1 more source
Challenging common bolus advisor for self-monitoring type-I diabetes patients using Reinforcement Learning [PDF]
arXiv, 2020 Patients with diabetes who are self-monitoring have to decide right before each meal how much insulin they should take. A standard bolus advisor exists, but has never actually been proven to be optimal in any sense. We challenged this rule applying Reinforcement Learning techniques on data simulated with T1DM, an FDA-approved simulator developed by ...
arxiv
Microfluidics‐Based Microcarriers for Live‐Cell Delivery
Advanced Science, EarlyView.In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang +3 more
wiley +1 more source
Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats. [PDF]
PLoS ONE, 2013 Recurrent/moderate (R/M) hypoglycemia is common in type 1 diabetes patients. Moderate hypoglycemia is not life-threatening, but if experienced recurrently it may present several clinical complications. Activated PARP-1 consumes cytosolic NAD, and because
Bo Young Choi +7 more
doaj +1 more source
Prediction of Daytime Hypoglycemic Events Using Continuous Glucose Monitoring Data and Classification Technique [PDF]
arXiv, 2017 Daytime hypoglycemia should be accurately predicted to achieve normoglycemia and to avoid disastrous situations. Hypoglycemia, an abnormally low blood glucose level, is divided into daytime hypoglycemia and nocturnal hypoglycemia. Many studies of hypoglycemia prevention deal with nocturnal hypoglycemia. In this paper, we propose new predictor variables
arxiv
Glucose Variability: Timing, Risk Analysis, and Relationship to Hypoglycemia in Diabetes
Diabetes Care, 2016 Glucose control, glucose variability (GV), and risk for hypoglycemia are intimately related, and it is now evident that GV is important in both the physiology and pathophysiology of diabetes.
B. Kovatchev, C. Cobelli
semanticscholar +1 more source
A Touch Enabled Hemodynamic and Metabolic Monitor
Advanced Science, EarlyView.This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi +19 more
wiley +1 more source