Results 41 to 50 of about 182,826 (303)

Prevention of hypoglycemia-induced neuronal death by minocycline

Journal of Neuroinflammation, 2012
Diabetic patients who attempt strict management of blood glucose levels frequently experience hypoglycemia. Severe and prolonged hypoglycemia causes neuronal death and cognitive impairment.
Won Seok, Kim Jin, Yoo Byung, Sohn Min, Kauppinen Tiina M, Park Man-Seong, Kwon Hyung-Joo, Liu Jialing, Suh Sang   +8 more
doaj   +1 more source

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]

, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C, Gonzalez, Reyna, Hofman, Florence M, Louie, Stan G, Pao, Peng-Wen, Pirrung, Michael C, Schönthal, Axel H, Sharma, Natasha, Thomas, Simmy   +8 more
core   +2 more sources

Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan

BMC Endocrine Disorders, 2019
Background Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment.
Mohammad J. Alkhatatbeh, Nedaa A. Abdalqader, Mohammad A. Y. Alqudah   +2 more
doaj   +1 more source

Continuous Glucose and Heart Rate Monitoring in Young People with Type 1 Diabetes: An Exploratory Study about Perspectives in Nocturnal Hypoglycemia Detection

Metabolites, 2020
A combination of information from blood glucose (BG) and heart rate (HR) measurements has been proposed to investigate the HR changes related to nocturnal hypoglycemia (NH) episodes in pediatric subjects with type 1 diabetes (T1D), examining whether they
Valeria Calcaterra, Pietro Bosoni, Lucia Sacchi, Gian Vincenzo Zuccotti, Savina Mannarino, Riccardo Bellazzi, Cristiana Larizza   +6 more
doaj   +1 more source

A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11. [PDF]

, 2017
The ATP-sensitive potassium channel (KATP) functions as a metabo-electric transducer in regulating insulin secretion from pancreatic β-cells. The pancreatic KATP channel is composed of a pore-forming inwardly-rectifying potassium channel, Kir6.2, and a ...
Ferrara, Christine, German, Michael, Gitelman, Stephen, Long, Roger, Yang, Shi-Bing, Yang, Yen-Yu   +5 more
core   +1 more source

Autonomic dysfunction and risk of severe hypoglycemia among individuals with type 2 diabetes

JCI Insight, 2022
There are limited data on the link between cardiac autonomic neuropathy (CAN) and severe hypoglycemia in type 2 diabetes. Here, we evaluated the associations of CAN with severe hypoglycemia among 7,421 adults with type 2 diabetes from the Action to ...
Arnaud D. Kaze, Matthew F. Yuyun, Rexford S. Ahima, Michael R. Rickels, Justin B. Echouffo-Tcheugui   +4 more
doaj   +1 more source

An auto-ethnographic study of co-produced health research in a patient organisation: unpacking the good, the bad, and the unspoken

Research Involvement and Engagement
Background In rare diseases, limited access to services and rare disease experts may force families to act as medical advocates for their child; they can volunteer to support clinician-initiated research or initiate and lead research themselves.
Astrid Janssens, Danielle Drachmann, Kristy Barnes-Cullen, Austin Carrigg, Henrik Thybo Christesen, Becky Futers, Yvette Ollada Lavery, Tiffany Palms, Jacob Sten Petersen, Pratik Shah, Paul Thornton, Joseph Wolfsdorf   +11 more
doaj   +1 more source

Severe Hypoglycemia: Is It Still a Threat for Children and Adolescents With Type 1 Diabetes?

Frontiers in Endocrinology, 2020
Severe hypoglycemia is defined as a condition with serious cognitive dysfunction, such as a convulsion and coma, requiring external help from other persons.
Tatsuhiko Urakami
doaj   +1 more source

1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy [PDF]

Endocrinology and Metabolism, 2016
BackgroundThe identification of a marker for hypoglycemia could help patients achieve strict glucose control with a lower risk of hypoglycemia. 1,5-Anhydro-D-glucitol (1,5-AG) reflects postprandial hyperglycemia in patients with well-controlled diabetes,
Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source