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Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications [PDF]

Biomedicines
Hypoglycemia is a particular problem in people with diabetes while it can also occur in other clinical circumstances. Hypoglycemia unawareness describes a condition in which autonomic and neuroglycopenic symptoms of hypoglycemia decrease and hence are ...
Laura Hölzen, Bernd Schultes, Sebastian M. Meyhöfer, Svenja Meyhöfer   +3 more
doaj   +4 more sources

Factors associated with hypoglycemia unawareness and severe hypoglycemia in type 1 diabetes mellitus patients [PDF]

Journal of Diabetes Investigation, 2022
Aims/Introduction Several factors are associated with hypoglycemia unawareness and severe hypoglycemia, but few large studies have analyzed Japanese patients with type 1 diabetes.
Satoshi Takagi, Junnosuke Miura, Mikako Takita, Shota Mochizuki, Takuya Asanuma, Sari Hoshina, Hiroko Takaike, Yasuko Uchigata, Tetsuya Babazono   +8 more
doaj   +2 more sources

Hypoglycemia unawareness among insulin-treated diabetic patients in Madinah, Saudi Arabia: prevalence and risk factors [PDF]

Frontiers in Endocrinology, 2023
BackgroundHypoglycemia unawareness (HU) is associated with significant risks. Screening for impaired awareness of hypoglycemia in patients with diabetes is important to minimize those risks. There are limited data on the prevalence of HU in patients with
Amal M. Qasem Surrati, Alhanouf Ayed Alanazi, Samyah Sami Bukhari, Eman Mohammed Alfadhli, Eman Mohammed Alfadhli   +4 more
doaj   +2 more sources

Persistent Postgastrectomy Hypoglycemia Unawareness in Patients With Gastric Cancer Unveiled by a Prospective Study [PDF]

Annals of Surgery Open, 2022
Objective:. Late dumping syndrome is a common postgastrectomy complication characterized by reactive hypoglycemia. This study aimed to explore the glycemic trend in patients who underwent gastrectomy for gastric cancer and clarify its changes over time ...
Takeshi Kubota, MD, PhD, Masayuki Yubakami, MD, Emi Ushigome, MD, PhD, Takuma Ohashi, MD, PhD, Katsutoshi Shoda, MD, PhD, Hirotaka Konishi, MD, PhD, Atsushi Shiozaki, MD, PhD, Hitoshi Fujiwara, MD, PhD, Kazuma Okamoto, MD, PhD, Michiaki Fukui, MD, PhD, Eigo Otsuji, MD, PhD   +10 more
doaj   +2 more sources

Comprehensive evaluation of patterns of hypoglycemia unawareness (HUA) and glycemic variability (GV) in patients with fibrocalculous pancreatic diabetes (FCPD): A cross-sectional study from South India. [PDF]

PLoS ONE, 2022
ObjectivesHypoglycemia unawareness (HUA) in patients with FCPD is common with an unclear etiology. We evaluated the prevalence, characteristics of HUA, glycemic variability (GV), its possible association with pancreatic glucagon secretion & cardiac ...
Riddhi Dasgupta, Felix K Jebasingh, Shajith Anoop, Santhya Seenivasan, Mathews Edatharayil Kurian, Flory Christina, Gracy Varghese, Pamela Christudoss, K U Lijesh, Deepu David, Sudipta Dhar Chowdhury, Thomas V Paul, Nihal Thomas   +12 more
doaj   +2 more sources

Characterizing Glycemic Control and Sleep in Adults with Long-Standing Type 1 Diabetes and Hypoglycemia Unawareness Initiating Hybrid Closed Loop Insulin Delivery [PDF]

Journal of Diabetes Research, 2021
Nocturnal hypoglycemia is life threatening for individuals with type 1 diabetes (T1D) due to loss of hypoglycemia symptom recognition (hypoglycemia unawareness) and impaired glucose counter regulation.
Susan Kohl Malone, Amy J. Peleckis, Laura Grunin, Gary Yu, Sooyong Jang, James Weimer, Insup Lee, Michael R. Rickels, Namni Goel   +8 more
doaj   +2 more sources

Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes. [PDF]

PLoS ONE, 2019
Asprosin is a counter-regulatory hormone to insulin which plays a role in fasting. It may therefore also play a role in hypoglycaemia unawareness, which has been subsequently examined in this pilot study.
Jan Benedikt Groener, Aikaterini Valkanou, Zoltan Kender, Jan Pfeiffenberger, Lars Kihm, Thomas Fleming, Peter Paul Nawroth, Stefan Kopf   +7 more
doaj   +2 more sources

Hypoglycemia unawareness identified by continuous glucose monitoring system is frequent in outpatients with type 2 diabetes without receiving intensive therapeutic interventions [PDF]

Diabetology & Metabolic Syndrome, 2022
Background Patients with diabetes are prone to asymptomatic hypoglycemia (AH) due to diminished ability to perceive the onset of hypoglycemia. However, the actual prevalence and influencing factors of AH in outpatients with type 2 diabetes (T2DM) have ...
Bingkun Huang, Qiuhui Jiang, Ting Wu, Qingbao Shen, Wengui Wang, Shoubi Wang, Yinxiang Huang, Shunhua Wang, Peiying Huang, Mingzhu Lin, Xiulin Shi, Xuejun Li   +11 more
doaj   +2 more sources

Association between hypoglycemia unawareness and cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus: a prospective cohort study [PDF]

Diabetology & Metabolic Syndrome
Background Diabetes has emerged as the third most significant global public health challenge. Among patients with type 2 diabetes mellitus (T2DM), cardiovascular autonomic neuropathy (CAN) represents a prevalent yet frequently overlooked complication ...
Siqi Li, Xiangxiang Shan, Xing Wei, Wu Dai, Yonghong Cao   +4 more
doaj   +2 more sources

Hypoglycemia unawareness prevention: Targeting glucagon production. [PDF]

Physiol Behav, 2016
Insulin-dependent individuals with diabetes are at risk for a severe hypoglycemic event that may predispose them to several repeat episodes during which the normal counter regulatory mechanisms that protect against hypoglycemia fail to be activated. This state of hypoglycemia unawareness is characterized by a failure of glucagon release, preventing ...
Samson WK, Stein LM, Elrick M, Salvatori A, Kolar G, Corbett JA, Yosten GL.   +6 more
europepmc   +4 more sources