Association between hypoglycemia unawareness and cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus: a prospective cohort study. [PDF]
Diabetol Metab SyndrBackground Diabetes has emerged as the third most significant global public health challenge. Among patients with type 2 diabetes mellitus (T2DM), cardiovascular autonomic neuropathy (CAN) represents a prevalent yet frequently overlooked complication ...
Li S, Shan X, Wei X, Dai W, Cao Y.
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Hypoglycemia unawareness and autonomic dysfunction in diabetes: Lessons learned and roles of diabetes technologies. [PDF]
J Diabetes Investig, 2020 Impaired awareness of hypoglycemia (IAH) is a reduction in the ability to recognize low blood glucose levels that would otherwise prompt an appropriate corrective therapy.
Lin YK, Fisher SJ, Pop-Busui R.
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Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes: Beyond Hypoglycemia Unawareness. [PDF]
Clin Diabetes, 2022 Giannakopoulos A +3 more
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The Antinarcolepsy Drug Modafinil Reverses Hypoglycemia Unawareness and Normalizes Glucose Sensing of Orexin Neurons in Male Mice. [PDF]
Diabetes, 2023 Perifornical hypothalamus (PFH) orexin glucose-inhib-ited (GI) neurons that facilitate arousal have been impli-cated in hypoglycemia awareness. Mice lacking orexin exhibit narcolepsy, and orexin mediates the effect of the antinarcolepsy drug modafinil ...
Patel V +7 more
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Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity
Periodontology 2000, EarlyView., 2023 Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti +2 more
wiley +1 more source
Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. [PDF]
J Clin Invest, 2018 Among nondiabetic individuals, mild glucose decrements alter brain activity in regions linked to reward, motivation, and executive control. Whether these effects differ in type 1 diabetes mellitus (T1DM) patients with and without hypoglycemia awareness remains unclear.Forty-two individuals (13 healthy control [HC] subjects, 16 T1DM individuals with ...
Hwang JJ +12 more
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Endocrine Reviews, 1991 Hypoglycemia unawareness can occur in diabetic as well as nondiabetic individuals. A single causative mechanism for its occurrence is not yet apparent. It is likely to be multifactorial but current evidence favors a major role for some type of CNS adaptation.
J E, Gerich +4 more
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Mechanisms of hypoglycemia unawareness and implications in diabetic patients. [PDF]
World J Diabetes, 2015 Hypoglycemia unawareness (HU) is defined at the onset of neuroglycopenia before the appearance of autonomic warning symptoms. It is a major limitation to achieving tight diabetes and reduced quality of life. HU occurs in approximately 40% of people with type 1 diabetes mellitus (T1DM) and with less frequency in T2DM.
Martín-Timón I, Del Cañizo-Gómez FJ.
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Acute hypoglycemia impairs executive cognitive function in adults with and without type 1 diabetes [PDF]
, 2013 OBJECTIVE Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management.
Graveling, Alex J. +2 more
core +1 more source
Current and future therapies to treat impaired awareness of hypoglycemia
Frontiers in Pharmacology, 2023 In order to achieve optimal glycemic control, intensive insulin regimes are needed for individuals with Type 1 Diabetes (T1D) and insulin-dependent Type 2 Diabetes (T2D).
Erica L. Macon +12 more
doaj +1 more source