Mechanisms of hypoglycemia unawareness and implications in diabetic patients. [PDF]
World J Diabetes, 2015 Hypoglycemia unawareness (HU) is defined at the onset of neuroglycopenia before the appearance of autonomic warning symptoms. It is a major limitation to achieving tight diabetes and reduced quality of life. HU occurs in approximately 40% of people with type 1 diabetes mellitus (T1DM) and with less frequency in T2DM.
Martín-Timón I, Del Cañizo-Gómez FJ.
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Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. [PDF]
J Clin Invest, 2018 Among nondiabetic individuals, mild glucose decrements alter brain activity in regions linked to reward, motivation, and executive control. Whether these effects differ in type 1 diabetes mellitus (T1DM) patients with and without hypoglycemia awareness remains unclear.Forty-two individuals (13 healthy control [HC] subjects, 16 T1DM individuals with ...
Hwang JJ +12 more
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Hypoglycemia unawareness and autonomic dysfunction in diabetes: Lessons learned and roles of diabetes technologies [PDF]
Journal of Diabetes Investigation, 2020 Impaired awareness of hypoglycemia (IAH) is a reduction in the ability to recognize low blood glucose levels that would otherwise prompt an appropriate corrective therapy.
Yu Kuei Lin +2 more
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Increased brain transport and metabolism of acetate in hypoglycemia unawareness. [PDF]
J Clin Endocrinol Metab, 2013 Intensive insulin therapy reduces the risk for long-term complications in patients with type 1 diabetes mellitus (T1DM) but increases the risk for hypoglycemia-associated autonomic failure (HAAF), a syndrome that includes hypoglycemia unawareness and defective glucose counterregulation (reduced epinephrine and glucagon responses to hypoglycemia).The ...
Gulanski BI +6 more
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Impaired awareness of hypoglycemia: can structured education address this persistent challenge? [PDF]
Frontiers in EndocrinologyImpaired Awareness of Hypoglycemia (IAH) describes a condition in insulin-treated diabetic patients characterized by a diminished ability to perceive the onset of acute hypoglycemia.
Yuanyuan Chen +3 more
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Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes: Beyond Hypoglycemia Unawareness. [PDF]
Clin Diabetes, 2022 Giannakopoulos A +3 more
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Endocrinology, Diabetes & Metabolism Case Reports, 2023 Unawareness of postprandial hypoglycemia for 5 years was identified in a 66-year-old man at a local clinic. The patient was referred to our hospital because of this first awareness of hypoglycemia (i.e.
Rikako Nakajima +11 more
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Minimizing Hypoglycemia with Insulin Therapy: The “THINK” Strategy
Chronicle of Diabetes Research and Practice, 2022 Iatrogenic hypoglycemia is the most feared and common complication of insulin therapy. Hypoglycemia can have serious consequences and can be potentially life-threatening. In addition to the neurological manifestations of severe hypoglycemia, hypoglycemia
Gagan Priya, Emmy Grewal
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Revista de la Facultad de Medicina Humana, 2022 Diabetes mellitus is a public health problem that causes early and late complications. Continuous glucose monitoring (CGM) has become the main technological tool for real-time glycemic control and has the potential to prevent complications.
Sonia H. Perez Cavero +2 more
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Influence of erythropoietin on cognitive performance during experimental hypoglycemia in patients with type 1 diabetes mellitus: a randomized cross-over trial. [PDF]
PLoS ONE, 2013 The incidence of severe hypoglycemia in type 1 diabetes has not decreased over the past decades. New treatment modalities minimizing the risk of hypoglycemic episodes and attenuating hypoglycemic cognitive dysfunction are needed.
Peter Lommer Kristensen +8 more
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