Results 71 to 80 of about 189,446 (330)

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Abnormally low Bispectral index and severe hypoglycemia during maintenance of and recovery from general anesthesia in diabetic retinopathy surgery: two case reports

BMC Anesthesiology, 2018
Background Hypoglycemia is one of the most fatal complications during the perioperative period. General anesthesia or sedation can mask a hypoglycemia-altered mental status. Acute hypoglycemia might result in permanent brain injury.
Chunhua Xi, Chuxiong Pan, Tianzuo Li
doaj   +1 more source

Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence. [PDF]

, 2015
BackgroundWe hypothesize that depression in type 2 diabetes might be associated with poor glycemic control, in part due to suboptimal self-care. We tested this hypothesis by examining the associations of depression with clinical and laboratory findings ...
Chan, Juliana Cn, China Depression in Chinese Patients with Type 2 Diabetes (DD2) Study Group, Guo, Xiaohui, Ji, Linong, Jia, Weiping, Kong, Alice Ps, Li, Wenhui, Luk, Andrea Oy, Morisky, Donald E, Oldenburg, Brian, Sartorius, Norman, Ting, Rose Zw, Weng, Jianping, Wing, Yun-Kwok, Yang, Wenying, Zhang, Yuying   +15 more
core   +1 more source

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source

Hypoglycemia in blood glucose level in type 2 diabetic Japanese patients by continuous glucose monitoring

Diabetology & Metabolic Syndrome, 2019
Background Hypoglycemia is associated with cardiovascular diseases, increased risk of death. Therefore, it is important to avoid hypoglycemia. The aim of this study was to characterize hypoglycemia according to glycated hemoglobin (HbA1c) level and ...
Maiko Hajime, Yosuke Okada, Hiroko Mori, Fumi Uemura, Satomi Sonoda, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto, Yoshiya Tanaka   +9 more
doaj   +1 more source

Essential Updates 2023/2024: Recent Advances of Multimodal Approach in Patients for Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Gastric cancer remains a major global health burden, especially in East Asia. Recent years have brought significant advances in multimodal management, including surgery, perioperative chemotherapy, immunotherapy, and supportive care. This review summarizes key updates from 2023 to 2024, focusing on surgical innovations, perioperative systemic ...
Katsutoshi Shoda, Yoshihiko Kawaguchi, Suguru Maruyama, Daisuke Ichikawa   +3 more
wiley   +1 more source

Co‐producing an inclusive‐care model for young people transitioning from adolescent eating disorder services to adult care: A qualitative study protocol for Transition for Eating Disorder Youth intervention

European Eating Disorders Review, EarlyView., 2023
Abstract Eating disorders (EDs) present a chronic issue to child paediatric mental health services due to their high mortality and relapse rates. The transition from Child and Adolescent Mental Health Services to Adult Mental Health Services is a particularly high‐risk period for young people with EDs given their high vulnerability to change, which can
Maria Livanou, Anya Heneghan, Elli Bouliou, Grace Hill, Katharine Mills, Sophie Naylor Roll, Zara Smalley, Jun Teh, Janet Treasure   +8 more
wiley   +1 more source

Retrospective evaluation of a national guideline to prevent neonatal hypoglycemia

Pediatrics and Neonatology, 2017
Hypoglycemia is common in neonates and may cause adverse neurological outcomes. Guidelines should aim to prevent repeated hypoglycemic episodes in risk groups, but they are not usually stratified according to the severity of hypoglycemia risk, which may ...
Annett Helleskov Rasmussen, Sonja Wehberg, Jesper Fenger-Groen, Henrik Thybo Christesen   +3 more
doaj   +1 more source

Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats. [PDF]

PLoS ONE, 2013
Recurrent/moderate (R/M) hypoglycemia is common in type 1 diabetes patients. Moderate hypoglycemia is not life-threatening, but if experienced recurrently it may present several clinical complications. Activated PARP-1 consumes cytosolic NAD, and because
Bo Young Choi, Jin Hee Kim, Hyun Jung Kim, Jin Hyuk Yoo, Hong Ki Song, Min Sohn, Seok Joon Won, Sang Won Suh   +7 more
doaj   +1 more source

Comparison of insulin detemir and insulin glargine in a Basal-Bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: A 52-week, multinational, randomized, open-label, parallel-group, treat-to-target noninferiority trial [PDF]

, 2009
Objective: The primary study objective was to determine whether insulin detemir (detemir) was noninferior to insulin glargine (glargine) as the basal insulin in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in terms of glycemic ...
Albright, Bolli, Bruce Bode, Buse, Christoph Koenen, Devries, Garg, Havelund, Heinemann, Heinemann, Heise, Heise, Hermansen, Hougaard, Jehle, Klein, Le Floch, Montgomery, Owens, Pieber, Ratner, Russell-Jones, Simon Heller   +22 more
core   +1 more source