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Approach to the Hypoglycemic Patient

Emergency Medicine Clinics of North America, 2023
Hypoglycemia is commonly encountered in the emergency department. Patients can present with a myriad of symptoms and its presentation can mimic other more serious diagnoses. Despite the relative ease of its management, clinicians often miss the diagnosis or mismanage it even when discovered.
Molly, Chang, George C, Willis
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Oral Hypoglycemic Agents

Primary Care: Clinics in Office Practice, 1977
Oral agents should not be used in the treatment of patients with asymptomatic maturity-onset diabetes. The indication for sulfonylureas is symptomatic maturity-onset diabetes or excessive hyperglycemia--fasting blood sugar over 300 mg per 100 ml--in the elderly patient who cannot or will not take insulin. The use of biguanides cannot be recommended.
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Hypoglycemic Action of Tryptophan

Diabetes, 1973
These studies were designed to define the mechanism by which the tryptophan metabolite, quinolinic acid, blocks gluconeogenesis and to determine the role it plays in influencing this process under physiologic and pathologic conditions. An alteration in the level of gluconeogenic intermediates occurred at a quinolinic acid content of 43 ng.
H G, McDaniel, B R, Boshell, W J, Reddy
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Hypoglycemic Brain Damage

Metabolic Brain Disease, 2004
Hypoglycemia was long considered to kill neurons by depriving them of glucose. We now know that hypoglycemia kills neurons actively from without, rather than by starvation from within. Hypoglycemia only causes neuronal death when the EEG becomes flat. This usually occurs after glucose levels have fallen below 1 mM (18 mg/dl) for some period, depending ...
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Oral Hypoglycemic Agents

Medical Clinics of North America, 1988
The sulfonylureas remain the most important oral agents, although their chronic hypoglycemic actions are still unexplained and the evidence on their relative efficacy is inconclusive. Data on relative safety suggest that chlorpropamide is the most toxic sulfonylurea but glyburide causes dangerous hypoglycemia as often as chlorpropamide.
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The management of the hypoglycemic patient

World Journal of Surgery, 1982
AbstractOrganic hypoglycemia may be caused by an insulinoma. This is a rare tumor, multiple in about 10% and malignant in about 10% of cases. Multiplicity is particularly likely when insulinoma occurs as part of the MEN 1 syndrome. When a patient exhibits Whipple's triad, synchronous blood sugar and insulin estimations must be made, and repeated during
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Potential Hypoglycemic Sulfonylureas

Journal of Pharmaceutical Sciences, 1964
A series of N ′-alkyl- N - p -phenylbenzenesulfonylureas and N , N ′-bis ( N -alkylcarbamyl) 4,4′-biphenyldisulfonamides has been prepared for pharmacological studies of their hypoglycemic activities.
K A, NIEFORTH, G L, JENKINS, A M, KNEVEL
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Hypoglycemic Peripheral Neuropathy

Archives of Neurology, 1969
PERIPHERAL neuropathy is a rare finding in spontaneous hypoglycemia, and only 22 patients have been reported in the literature (Table 1). 1-12 The purpose of this communication is to report two additional cases and to analyze the clinical presentation of peripheral neurological symptoms that occasionally accompany spontaneous hypoglycemia.
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Oral Hypoglycemic Agents

Pediatrics, 1969
I noted with interest the article by Drs. Adam and Schwartz, "Should Oral Hypoglycemic Agents Be Used in Pediatric and Pregnant Patients?" (Pediatrics, 42:819, 1968). In regard to juvenile diabetics, his conclusions were an echo of what usually appears in the ped iatric literature, namely, these drugs have no place in the management of any pediatric ...
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Oral Hypoglycemic Agents

New England Journal of Medicine, 1989
ORAL hypoglycemic agents are commonly prescribed drugs. In the United States they account for about 1 percent of all prescriptions.1 This review discusses the pharmacology, mechanisms of action, ef...
John A. Oates   +2 more
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