Results 91 to 100 of about 15,559,661 (310)

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro

Drug Design, Development and Therapy, 2017
The present study investigated the possible antiobesity and hypoglycemic effects of phloretin (Ph). In an attempt to discover the hypoglycemic effect and potential mechanism of Ph, we used the streptozotocin-induced diabetic rats and (L6) myotubes. Daily
Xin Shen, Nan Zhou, Le Mi, Zishuo Hu, Li-Bin Wang, Xue-Ying Liu, Sheng-Yong Zhang   +6 more
semanticscholar   +1 more source

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, EarlyView.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source

Hypoglycemic effect of the aqueous extract from Acalypha argomuelleri Briq. (Euphorbiaceae) 'Sweet stick' leaves in Rattus rattus var. albinus [version 2; peer review: 2 approved, 1 not approved]

F1000Research
Introduction Diabetes mellitus (DM) is a chronic metabolic disease representing a global public health concern and is associated with severe complications such as cardiovascular and renal diseases.
Doyle Isabel Benel Fernández, Néstor Manuel Rodríguez Alayo, Berta Loja Herrera, Jorge Guillermo Morales Ramos, César Sánchez Marín, María Ema Soledad Mocarro Willis, Carolina Susana Loayza Estrada, Luis Felipe Pérez Medina   +7 more
doaj   +1 more source

Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

International Journal of Nanomedicine, 2017
Diabetes mellitus is an incurable metabolic disorder that seriously threatens human health. At present, there is no effective medication available to defeat it.
Juntao Yin, Yantao Hou, Yuyun Yin, Xiao-Yong Song   +3 more
semanticscholar   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Evaluation of the toxicity and hypoglycemic effect of the aqueous extracts of Cnidoscolus quercifolius Pohl

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017
Diabetes mellitus is one of the most common chronic degenerative diseases, and it is estimated to increase worldwide to around 415 million and to impact 642 million in 2040.
S. Lira, N. V. Canabrava, Stephen Rathinaraj Benjamin, J. Y. G. Silva, D. A. Viana, C. L. S. Lima, P. M. Paredes, M. Marques, E. Pereira, E. A. Queiroz, M. Guedes   +10 more
semanticscholar   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

ESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano   +11 more
wiley   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

The hypoglycemic metabolites and potential mechanisms of Lilium lancifolium (Juandan lily)

Frontiers in Pharmacology
In Chinese folk medicine, lily bulbs have traditionally been used to help lower blood glucose levels. Numerous studies have demonstrated that extracts from lily bulbs possess significant hypoglycemic activity. However, the specific active metabolites and
Qinxuan Wu, Kunyu Xiao, Di Zhao, Rui Tang, Weiping Liu, Feng Li, Hexiang Wang, Fengming Chen, Fengming Chen   +8 more
doaj   +1 more source