Results 71 to 80 of about 15,559,661 (310)

Novel probiotic Lactobacillus helveticus WIS02 alleviates diabetes through multi-pronged regulation of glycolipid metabolism, pancreatic protection and gut microbiota remodeling

Frontiers in Microbiology
BackgroundDiabetes mellitus poses a global health burden with limited therapies derived from breast milk targeting its systemic complications. Probiotics like Lactobacillus helveticus show metabolic benefits, but strain-specific efficacy and mechanisms ...
Shuang Guo, Yuying Li, Yanan Yang, Yuexiao Jiang, Yufeng Wang, Ying Cao, Yunfeng Duan, Chongming Wu, Chongming Wu, Chongming Wu   +9 more
doaj   +1 more source

Efek hipoglikemik tepung komposit (ubi jalar ungu, jagung kuning, dan kacang tunggak) pada tikus diabetes induksi streptozotocin

Jurnal Gizi Klinik Indonesia, 2014
Background: The composite flour (50% sweet potato, 30% corn, and 20% cowpea) had proven that it could substitute 100% wheat flour for biscuit making.
Carolina Sisca Djunaidi, Dian Rachmawanti Affandi, Danar Praseptiangga   +2 more
doaj   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Bioactive Profiling and Anti-Hyperglycemic Potential of Berberis nummularia Bunge: Role of Polyphenols and α-Amylase Inhibition

Foods
The Berberis nummularia fruit is rich in polyphenols and which are associated with the inhibition of carbohydrate-digesting enzymes. However, the phytochemical compositions, antioxidant strength, and the ability of the fruits on the inhibition of α ...
Buhailiqiemu Abudureheman, Lin Chen, Jianlin Zhang, Shuai Zhu, Jinjuan Wang, Junli Huang, Chaoying Xie, Haibo Pan, Xingqian Ye   +8 more
doaj   +1 more source

EFEK HIPOGLIKEMIK EKSTRAK ETANOL UMBI KETELA RAMBAT (Ipomoea batatas P) (EEUKR) PADA MENCIT SWISS YANG DIINDUKSI ALOKSAN

Pharmaciana, 2014
Sweet potatos rood contain lots of beta-carotene, polyphenols and flavonoids. Alloxan proven pancreatic cell damage through oxidative stress mechanisms.
Akrom Akrom, Harjanti P D, Armansyah T
doaj   +1 more source

Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii

Natural Product Research, 2019
Three new acetophenones, named cynwilforones A–C (1–3), together with cynandione A (4) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds 1
Haowen Jiang, Shanshan Gu, Lei Cao, Shenglin Jiang, Jing Lin, Yan Chen, Ling Wang, He Jiao, Jing-Ya Li, Wei-Min Zhao, Jin-Long Li   +10 more
semanticscholar   +1 more source

Effect of purity of tea polysaccharides on its antioxidant and hypoglycemic activities.

Journal of food biochemistry, 2020
The effects of purity of tea polysaccharides (TPS) on its five antioxidant activities and hypoglycemic activities in vitro were studied. The results showed that the higher the purity of TPS, the lower the antioxidant capacity.
Ming-Hao Fan, Jun-Xiang Zhu, Yilin Qian, Wei Yue, Ying Xu, Dandan Zhang, Yu-Qi Yang, Xiaoyan Gao, Hai-Yue He, Dong-Feng Wang   +9 more
semanticscholar   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Exploration on hypoglycemic mechanism of components in Guangdong finger citron based on network pharmacology and molecular docking

Shipin yu jixie
ObjectiveTo study the potential targets of hypoglycemic effects of components in Guangdong Finger Citron (GFC) based on network pharmacology.MethodsGenes associated with type 2 diabetes mellitus (T2DM) and hyperglycemia are screened using the TTD ...
MA Wencong, WU Yuxiao, ZHONG Cheng, ZHOU Aimei   +3 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source