Results 61 to 70 of about 77,706 (265)

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

Animal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang, Bo Wang, Mengya Wang, Haizhan Tang, Mingjian Liu, Da Zheng, Zhongyi Zhai, Jiahang Li, Jinyang Xie, Chaofan Jin, Jingjie Hu, Zhenmin Bao   +11 more
wiley   +1 more source

Bioactive Profiling and Anti-Hyperglycemic Potential of Berberis nummularia Bunge: Role of Polyphenols and α-Amylase Inhibition

Foods
The Berberis nummularia fruit is rich in polyphenols and which are associated with the inhibition of carbohydrate-digesting enzymes. However, the phytochemical compositions, antioxidant strength, and the ability of the fruits on the inhibition of α ...
Buhailiqiemu Abudureheman, Lin Chen, Jianlin Zhang, Shuai Zhu, Jinjuan Wang, Junli Huang, Chaoying Xie, Haibo Pan, Xingqian Ye   +8 more
doaj   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Exploration on hypoglycemic mechanism of components in Guangdong finger citron based on network pharmacology and molecular docking

Shipin yu jixie
ObjectiveTo study the potential targets of hypoglycemic effects of components in Guangdong Finger Citron (GFC) based on network pharmacology.MethodsGenes associated with type 2 diabetes mellitus (T2DM) and hyperglycemia are screened using the TTD ...
MA Wencong, WU Yuxiao, ZHONG Cheng, ZHOU Aimei   +3 more
doaj   +1 more source

Development of obtaining stable substances for functional food products based on yacon (Smallanthus sonchifolius Poepp. & Endl.) powder root tubers and investigation of their hypoglycemic activity in rats

Біологічні студії, 2016
Methods of obtaining a stable substance for functional foods with antioxidant and hypoglycemic action based on powder root tubers of yacon’ are proposed.
A. Horbulinska, M. Khokhla, H. Hachkova, A. Zyn, R. Vildanova, O. Shulga, L. Mishchenko, N. Sybirna   +7 more
doaj   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Modern Biotechnology of Phellinus baumii – From Fermentation to Proteomics

Food Technology and Biotechnology, 2007
Phellinus baumii is a mushroom used as a folk medicine for a variety of human diseases in several Asian countries. Recently we have reported for the first time about the antidiabetic effect of the crude exopolysaccharides (EPS) produced from submerged ...
Hye Jin Hwang, Sang Woo Kim, Jong Won Yun   +2 more
doaj  

Hypoglycemic Effects of Silphium perfoliatum L. In Vitro and In Vivo and Its Active Composition Identification by UPLC-Triple-TOF-MS/MS

Pharmaceuticals
Background: Reducing postprandial blood glucose (PBG) is a crucial strategy for treating diabetes and minimizing the risk of complications. Developing efficient and safe α-glycosidase inhibitors from natural products to lower PBG has attracted much ...
Guoying Zhang, Liying Liu, Wenjing Jia, Luya Wang, Jihong Tao, Wei Zhang, Huilan Yue, Dejun Zhang, Xiaohui Zhao   +8 more
doaj   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Hypoglycemic effects of edible fungus polysaccharides: A mini review

Food & Medicine Homology
Diabetes mellitus (DM) is a chronic metabolic disorder with the feature of hyperglycemia, which has severely endangered human health. Edible fungus polysaccharides (EFP), which has great development potential, have attracted enormous attention since ...
Yan-Long Cui, Bo Li
doaj   +1 more source