Results 201 to 210 of about 15,559,661 (310)

Cinnamic Acid Attenuates Ethanol‐Exacerbated Hepatocyte Pyroptosis in Type 2 Diabetes via AMPK‐Mediated NLRP3/GSDMD Inhibition

Phytotherapy Research, EarlyView.
CA directly binds to and activates AMPK to suppress NLRP3/GSDMD signaling, thereby alleviating hepatocyte pyroptosis in T2DM mice. ABSTRACT Type 2 diabetes mellitus (T2DM) is frequently accompanied by chronic ethanol (ET) consumption, which worsens metabolic dysregulation and organ damage.
Huaiying Tang, Qin Xiang, Yue Zhang, Yu Zhang, Xiangxiang Fu, Liming Tan, Yongli Zhang, Siqi Li, Dong Gong, Xu Guo, Yonghong Zhang, Li Chen, Tao Zheng, Qibin Wang   +13 more
wiley   +1 more source

Synthesis and Hypoglycemic Effect of Insulin from the Venom of Sea Anemone Exaiptasia diaphana. [PDF]

Mar Drugs
Guo Q, Tang T, Lu J, Huang M, Zhang J, Ma L, Gao B.   +6 more
europepmc   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Proposed mechanisms of action participating in the hypoglycemic effect of the traditionally used Croton guatemalensis Lotsy and junceic acid, its main compound. [PDF]

Front Pharmacol
Moreno-Vargas AD, Andrade-Cetto A, Espinoza-Hernández FA, Mata-Torres G.   +3 more
europepmc   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Preparation of a Novel Oat β-Glucan-Chromium(III) Complex and Its Hypoglycemic Effect and Mechanism. [PDF]

Molecules
Li P, Wang Y, Wang X, Li R, Wang K, Jiang Y, Zhang M, Huang C, Ma Q, Sun J, Quan J.   +10 more
europepmc   +1 more source

Different blood lipid profiles and their role in cardiometabolic disease progression: A comparative study between an East Asian and European Large Prospective Cohorts

VIEW, EarlyView.
In this study, we analyzed data from the Kailuan study in China (N = 95,711) and the UK Biobank (N = 388,317), comprising adults free of CMDs at baseline. The results demonstrated distinct, population‐specific patterns regarding how blood lipids influence the transition from a healthy state to incident CMDs and subsequently to CMM.
Lili Huang, Zhe Huang, Fandi Mo, Xinming Xu, Yuchong Zhang, Xinqiang Ma, Tingting Geng, Chengkai Hu, Shiyi Li, Genmao Cao, Hanji Fang, Shouji Qiu, Zhicheng Zhang, Sun Liang, Xiang Gao, Shouling Wu, Lixin Wang   +16 more
wiley   +1 more source

Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes. [PDF]

Front Pharmacol
Feng Y, Ren Y, Zhang X, Yang S, Jiao Q, Li Q, Jiang W.   +6 more
europepmc   +1 more source

The Performance of Selective Screening Ultrasound to Detect the Small‐for‐Gestational‐Age Foetus: A Prospective Cohort Study Nested Within the DESiGN Randomised Control Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Evidence on the performance of foetal growth ultrasound parameters to detect the Small‐for‐Gestational‐Age (SGA) foetus for a selective cohort is limited. We report the performance of estimated foetal weight under the 10th percentile (EFW < 10th) at the last selective screening ultrasound to detect SGA based on gestational age of ...
Charles Arcus, James Elhindi, Chivon Winsloe, Andrew Copas, Sophie Relph, Annette Briley, Kirstie Coxon, Mark Johnson, Asma Khalil, Deborah A. Lawlor, Christoph Lees, Neil Marlow, Louise Page, Andrew Shennan, Jane Sandall, Tanya Nippita, Matias C. Vieira, Dharmintra Pasupathy   +17 more
wiley   +1 more source