Results 241 to 250 of about 15,559,661 (310)

The effect of the molecular weight of blackberry polysaccharides on gut microbiota modulation and hypoglycemic effect in vivo.

Food & Function
Blackberry polysaccharides with certain molecular weight distribution have good bioactivity. In this research, type 2 diabetes mice were used to investigate the hypoglycemic effect of blackberry polysaccharides with three different molecular weights, BBP
Xi Lai, Wei-Bing Xu, Shuyong Fu, Sheng-Hua Li, Xiong Fu, Chin-Ping Tan, Pingping Wang, Zu-Man Dou, Chun Chen   +8 more
semanticscholar   +1 more source

Structural characterization and hypoglycemic effect of polysaccharides of Polygonatum sibiricum.

Journal of Food Science
Polygonatum sibiricum polysaccharide (PSP) was extracted and purified from raw material obtained from P. sibiricum. The structural features of PSP were investigated by Congo red, circular dichroism spectrum, high-performance gel permeation chromatography,
Xin Wang, Meng-Yuan Yang, Ying Shen, Yipeng Zhang, Wei-Ye Xiu, S. Yu, Yong-Qiang Ma   +6 more
semanticscholar   +1 more source

The hypoglycemic effect of extract/fractions from Fuzhuan Brick-Tea in streptozotocin-induced diabetic mice and their active components characterized by LC-QTOF-MS/MS.

Journal of Food Science, 2020
Fuzhuan Brick-Tea is a postfermented product with the hypoglycemic effect, which is prepared from the leaves of Camellia sinensis var. sinensis. However, the material basis associated with the hypoglycemic effect was not clear.
Xingliang Xiang, Yi Xiang, Shuna Jin, Zhiqiang Wang, Yiqiang Xu, Chao Su, Qingxin Shi, Cheng Chen, Qing-Song Yu, Cheng-Wu Song   +9 more
semanticscholar   +1 more source

Synthesis and hypoglycemic effect of chrysin derivatives

Bioorganic & Medicinal Chemistry Letters, 1999
A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetec mice in spite of the fact that ...
J S, Shin, K S, Kim, M B, Kim, J H, Jeong, B K, Kim   +4 more
openaire   +2 more sources

Potentiation of Hypoglycemic Effect of Sulfonylureas by Halofenate

New England Journal of Medicine, 1975
We investigated the possibility of a drug interaction between the antilipemic agent halofenate and sulfonylureas. Twelve young, healthy men were given 1 g of tolbutamide by mouth before and after 12 days of double-blind treatment with 1 g per day of halofenate, or placebo. There was a significant increase in serum tolbutamide at eight, 10 and 12 hours (
A K, Jain, J R, Ryan, F G, McMahon
openaire   +2 more sources

Inhibitory effect of epigallocatechin-3-O-gallate on α-glucosidase and its hypoglycemic effect via targeting PI3K/AKT signaling pathway in L6 skeletal muscle cells.

International Journal of Biological Macromolecules, 2019
Epigallocatechin-3-O-gallate (EGCG), a tea polyphenol is renowned for its anti-diabetic properties, however limited studies elucidate its hypoglycemic mechanism from multi-perspectives. In the present study, the interaction between EGCG and α-glucosidase
Leilei Xu, Wei-Wei Li, Zhongqin Chen, Qing-Wen Guo, Chunli Wang, R. Santhanam, Hai-Xia Chen   +6 more
semanticscholar   +1 more source

Effect of Antacids on Activity of Oral Hypoglycemics

Journal of Pharmaceutical Sciences, 1981
The effect of some antacids on the dissolution and hypoglycemic activity of acetohexamide, tolazamide, and tolbutamide tablets was investigated, as was the adsorption of the three drugs onto the antacids. The dissolution rates of the three drugs in the presence of magnesium oxide, aluminum hydroxide, magnesium carbonate, and calcium carbonate increased
S A, Said, M E, Abdullah
openaire   +2 more sources

Improving hypoglycemic effect of insulin via the nasal administration of deep eutectic solvents.

International journal of pharmaceutics, 2019
This study aimed to develop biocompatible deep eutectic solvents (DESs) as carriers for improving the nasal delivery of insulin. The DES was prepared from malic acid and choline chloride broadly used in foods, drugs, or cosmetics as biocompatible ...
Yang Li, Xi-Ying Wu, Quan-Gang Zhu, Zhong-Jian Chen, Yi Lu, Jian-Ping Qi, Wei Wu   +6 more
semanticscholar   +1 more source

Hypoglycemic effect of dietary fibers from bamboo shoot shell: An in vitro and in vivo study.

Food and Chemical Toxicology, 2019
Bamboo shoot shell (BSS) was enzymatically decomposed to yield insoluble dietary fiber (IDF), soluble dietary fiber (SDF) and total dietary fiber (TDF), which were investigated for their hypoglycemic properties using in vitro and in vivo methods.
Ya-Feng Zheng, Qi Wang, Ju-Qing Huang, Dong-Ya Fang, Weijing Zhuang, Xianliang Luo, Xiao-Bo Zou, Baodong Zheng, Hui Cao   +8 more
semanticscholar   +1 more source

Hypoglycemic effect of Bauhinia cheilandra in rats

Fitoterapia, 2006
The extract of the methanolic leaves of Bauhinia cheilandra (BC) was tested on glucose loaded and alloxan-induced diabetic rats. In both tests, the methanolic extract at doses of 300, 600, and 900 mg/kg, has shown a statistically significant and considerable hypoglycemic activity.
E R, Almeida, M C, Guedes, J F C, Albuquerque, H, Xavier   +3 more
openaire   +2 more sources