Results 31 to 40 of about 15,559,661 (310)

The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis

Drug Metabolism And Disposition, 2020
Our previous study suggests that berberine (BBR) lowers lipids by modulating bile acids and activating intestinal farnesoid X receptor (FXR). However, to what extent this pathway contributes to the hypoglycemic effect of BBR has not been determined.
Run-Bin Sun, B. Kong, Na Yang, B. Cao, D. Feng, Xiaoyi Yu, C. Ge, Si-Qi Feng, Fei Fei, Jing-Qiu Huang, Zhen-Yao Lu, Yuan Xie, Chung S. Yang, Grace L. Guo, Guang-Ji Wang, Jiye Aa   +15 more
semanticscholar   +1 more source

Influence of losartan on the hypoglycemic activity of glimepiride in normal and diabetic rats

Therapeutic Advances in Endocrinology and Metabolism, 2013
Background: The influence of losartan on the hypoglycemic effect of glimepiride was studied in normal and diabetic rats. Method: Losartan and glimepiride were studied at a dose of 4.5 and 0.09 mg/kg and in normal and diabetic rats, respectively.
T.E.G.K. Murthy, Manogna K. Kommineni, Candasamy Mayuren   +2 more
doaj   +1 more source

Hypoglycemic Effect of Prolamin from Cooked Foxtail Millet (Setaria italic) on Streptozotocin-Induced Diabetic Mice

Nutrients, 2020
Millet proteins have been demonstrated to possess glucose-lowering and lipid metabolic disorder modulation functions against diabetes; however, the molecular mechanisms underlying their anti-diabetic effects remain unclear.
Yongxia Fu, Ruiyang Yin, Zhenyu Liu, Yan Niu, Erhu Guo, Ru-hong Cheng, Xianmin Diao, Yong Xue, Q. Shen   +8 more
semanticscholar   +1 more source

Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats

PLoS ONE, 2020
Background Diabetes mellitus is one of the most common todays public health problems. According to a survey by the World Health Organization, this metabolic disorder has reached global epidemic proportions, with a worldwide prevalence of 8.5% in the ...
G. R. Villas Boas, João Marcos Rodrigues Lemos, Matheus William de Oliveira, R. C. dos Santos, Ana Paula Stefanello da Silveira, Flávia Barbieri Bacha, Caren Naomi Aguero Ito, Ediane Bortolotte Cornelius, Fernanda Brioli Lima, Andrea Marisa Sachilarid Rodrigues, Nathália Belmal Costa, Felipe Francisco Bittencourt, Fernando Freitas de Lima, Marina Meirelles Paes, P. Gubert, S. Oesterreich   +15 more
semanticscholar   +1 more source

Hypoglycemic effect of okra aqueous extract on streptozotocin-induced diabetic rats

Food Science and Technology, 2020
Dkra ( Abelmoschusesculentus L.Moench) is widely planted in subtropical and tropical areas, with good palatability and a variety of biological activities. However, the hypoglycemic activity of okra aqueous extract and its mechanism were still unclear. On
Li Wu, M. Weng, Heng-Guang Zheng, Pu-Fu Lai, Bao-Sha Tang, Jun-Chen Chen, Yi-Bin Li   +6 more
semanticscholar   +1 more source

Plant/algal polysaccharides extracted by microwave: A review on hypoglycemic, hypolipidemic, prebiotic, and immune-stimulatory effect.

Carbohydrate Polymers, 2021
Microwave-assisted extraction (MAE) is an emerging technology to obtain polysaccharides with an extensive spectrum of biological characteristics. In this study, the hypoglycemic, hypolipidemic, prebiotic, and immunomodulatory (e.g., antiinflammatory ...
M. Mirzadeh, Ali Keshavarz Lelekami, L. Khedmat   +2 more
semanticscholar   +1 more source

Potential Hypoglycemic Effect of Pomegranate Juice and Its Mechanism of Action: A Systematic Review

Journal of Medicinal Food, 2020
Pomegranate juice (PJ) has gained popularity attributed to its phenolic compounds and their medicinal properties. Its potential hypoglycemic effect has been related to enzymatic inhibition, insulin release, and the protection of pancreatic tissue.
Carmen Alejandrina Virgen-Carrillo, A. G. Martínez Moreno, Elia Herminia Valdés Miramontes   +2 more
semanticscholar   +1 more source

Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins

Molecules, 2018
This study investigated the possible enhancement of berberine’s (BB) hypoglycemic activity by oligomeric proanthocyanidins (OPCs) and its underlying mechanism. The hypoglycemic activity of the studied compounds was evaluated in diabetic db/db mice.
Haoyue Zhang, Xueping Wang, Ting Wang, Kaixian Chen, Heyao Wang, Qi Jia, Yiming Li   +6 more
doaj   +1 more source

Drugs with secondary hypoglycemic effect

Public Health Economy and Management in Medicine
The problem of hypoglycemia induced by non-diabetic drugs, which is increasingly reported, has been studied. The hypoglycemic side effect of drugs is explained by different mechanisms and manifests individually depending on age, gender, comorbidities.
Ina Pogonea, Tatiana Chiriac, Carolina Catcov, Maria Mihalachi-Anghel, Liviu Mereacre   +4 more
semanticscholar   +1 more source

Medicinal Plants Galega officinalis L. and Yacon Leaves as Potential Sources of Antidiabetic Drugs

Antioxidants, 2021
Hypoglycemic and antioxidant properties of extracts of medicinal plants Galega officinalis L. (aboveground part) and yacon (Smallanthus sonchifolius Poepp.
Halyna Hachkova, Mariia Nagalievska, Zoriana Soliljak, Olena Kanyuka, Alicja Zofia Kucharska, Anna Sokół-Łętowska, Elena Belonovskaya, Vyacheslav Buko, Nataliia Sybirna   +8 more
doaj   +1 more source