Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR ser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy [PDF]
, 2017 Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial.
Al-Azzawi +46 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Nina Batorek Lukač +6 more
wiley +1 more source
Diagnosis and management of male hypogonadism in Germany
The Aging MaleBackground The extent to which male hypogonadism is diagnosed and treated remains ambiguous. This study scrutinizes the respective medical framework in Germany.Materials and methods This observational study retrospectively analyzes data from four million
Michael Zitzmann +4 more
doaj +1 more source
Testosterone deficiency in the aging male
Therapeutic Advances in Urology, 2016 Treatment for hypogonadism is on the rise, particularly in the aging population. Yet treatment in this population represents a unique challenge to clinicians.
J. Abram McBride +2 more
doaj +1 more source
Clinicopathologic assessment of hypogonadism in men with type 2 diabetes mellitus
Indian Journal of Endocrinology and Metabolism, 2016 Objective: To determine the prevalence of hypogonadism in men with type 2 diabetes mellitus and evaluate its clinical and pathologic correlates. Subjects and Methods: In a cross-sectional survey of 200 type 2 diabetic males aged 32-69 years, total ...
Theophilus E Ugwu +3 more
doaj +1 more source
Healthy Aging Men Do Not Suffer From Relevant Limitations of Their Reproductive Functions
Andrology, EarlyView.Abstract Background While metabolic disorders are well‐established contributors to testosterone decline and erectile dysfunction (ED), little is known about the natural progression of reproductive parameters in healthy aging men. Objectives This study aimed to evaluate longitudinal changes in reproductive parameters and sought to determine the ...
Simone Bier +8 more
wiley +1 more source
Apeced in Turkey: a case report and insights on genetic and phenotypic variability [PDF]
, 2018 APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune ...
Alessandra Fierabraccia +4 more
core +1 more source
Bleeding Disorders in Children With Genetic Diseases: A Narrative Review
Acta Paediatrica, EarlyView.ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol +6 more
wiley +1 more source
Use of testosterone replacement therapy to treat long-COVID-related hypogonadism
Endocrinology, Diabetes & Metabolism Case ReportsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can impair pituitary–gonadal axis and a higher prevalence of hypogonadism in post-coronavirus disease 2019 (COVID-19) patients compared with the general population has been highlighted. Here we
Alessandro Amodeo +3 more
doaj +1 more source
A Clinical Case of Hypogonadism and Anosmia Associated with a New Mutation of the KAL1/ ANOS1 Gene [PDF]
, 2023 Del Prete Michela +6 more
openalex +1 more source