Results 151 to 160 of about 72,413 (261)

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Open Reduction and Treatment with Bone Morphogenetic Protein-2 for Correction of Closed Tibial Pseudoarthrosis in a 32-Year-Old Non-smoking Male with Osteoporosis and Hypogonadism: A Case Report. [PDF]

J Orthop Case Rep
Hill S, Slack K, Perry F, Parhar K, Schmitz M.   +4 more
europepmc   +1 more source

Oncosexology: A Narrative Review on Sexual Health and Quality of Life in Cancer Patients

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer remains a major global public health problem. A key aspect of cancer care among survivors is sexual health. Cancer patients experience a range of sexual dysfunctions, including erectile dysfunction, vaginal dryness, dyspareunia, and reduced libido.
Pasquale Marino, Roberta Colangelo, Paola Amendola, Ilaria Bochicchio, Alessandro Rocco Lettini, Stefania Lapadula, Alda Giuliano, Martina Catalano, Francesca Sanseverino   +8 more
wiley   +1 more source

Aicardi‐Goutières Syndrome Type 6: Case Report and Structural Prediction Supporting a Dominant‐Negative Effect of the ADAR1 c.3019G>A Variant

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Aicardi–Goutières syndrome type 6 (AGS6) is a genetically determined autoinflammatory disorder, classically inherited in an autosomal recessive manner. We report a Czech child with a heterozygous ADAR1 NM_001111.5:c.3019G>A variant causing AGS6.
Katerina Turan, Petra Pokorna, Kamila Rihova, Jana Kubatova, Katerina Kozelkova, Eliska Hlouskova, Pavlina Danhofer, Petr Jabandziev, Jiri Damborsky, Regina Demlova, Ondrej Slaby, Katerina Slaba   +11 more
wiley   +1 more source

A Novel Marker in Hypogonadal Hypogonadism: Apelin. [PDF]

Sisli Etfal Hastan Tip Bul
Akansel Caglar A, Sebin E, Kartal Baykan E, Carlıoglu A.   +3 more
europepmc   +1 more source

Knuckle, Knuckle, Dimple, Dimple: Do Not Miss A Diagnostic Opportunity

Clinical Case Reports, Volume 14, Issue 4, April 2026.
Archibald's metacarpal sign is characterized by dimpling over the knuckles when the fist is clenched, resulting from relative shortening of the fourth and fifth metacarpals compared with the third. ABSTRACT Turner syndrome (TS) often presents with subtle or overlooked clinical signs, contributing to frequent diagnostic delays. We describe the case of a
Maria Chiara Pellegrin, Gianluca Tamaro, Alice Fachin, Egidio Barbi, Gianluca Tornese   +4 more
wiley   +1 more source

Brachymetatarsia as an Early Clue to Turner Syndrome

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Congenital anomalies of the extremities, particularly bilateral toe or finger malformations, may provide an early and valuable clue to an underlying genetic disorder and should prompt further diagnostic evaluation. Brachymetatarsia is a rare associated finding that may raise suspicion for Turner syndrome, particularly when diagnosis is delayed
Hounaida Mahfoud, Zaki Elhanchi
wiley   +1 more source

International Registry of NKX2‐1‐Related Disorders: Clinical, Genetic, and Imaging Perspectives

Movement Disorders, Volume 41, Issue 4, Page 889-900, April 2026.
Abstract Background NKX2‐1–related disorders result from heterozygous variants in NKX2‐1, a gene crucial for brain, lung, and thyroid development. Although movement disorders, hypothyroidism, and neonatal respiratory distress are recognized, the full phenotype and genotype–phenotype relationships remain incompletely defined.
Laia Nou‐Fontanet, Claudia Ravelli, Lydie Burglen, Sol Balsells Mejia, Angel Valls‐Villalba, Elies Roman Schiffels, Alice Innocenti, Beatriz Villafuerte, Ainara Salazar‐Villacorta, Vicente Quiroz, Andrea Sariego Jamardo, Giulia Bonato, Asun Díaz‐Gomez, Alexandra Afenjar, Catheline Vilain, Patricia Dumke da Silva Möller, Deyanira Garcia‐Navas Nuñez, Magdalena Krygier, Maria Judit Molnar, Łukasz Milanowski, Katrin Õunap, Micaela Pauni, Patricia Vega, Raphael Borie, Milena Villamil‐Osorio, Sanem Yilmaz, Dénes Zádori, Marta Zawadzka, Tahsin Stefan Barakat, Sebastian Neuens, Daniel de Natera‐de Benito, Dídac Casas‐Alba, Luca Soliani, Claudio M. de Gusmao, Giacomo Garone, Nicola Specchio, Miryam Carecchio, José C. Moreno, Francesca Magrinelli, Kailash P. Bhatia, Darius Ebrahimi‐Fakhari, Claudia Castiglioni, Manju Ann Kurian, João Nuno Carvalho, Roser Pons, Emmanuel Roze, Diane Doummar, Juan Darío Ortigoza‐Escobar   +47 more
wiley   +1 more source

Amenorrhea Induced by Hydrocephalus Due to Tuberculous Meningitis: A Rare Case Report and Literature. [PDF]

Int Med Case Rep J
Adnyana IBPP, Ritonga MA, Rachmawati A, Tjahjadi D, Anwar R, Hartanto AI.   +5 more
europepmc   +1 more source

Hypogonadotropic Hypogonadism

, 2014
Adamowicz, Jan, Aboumarzouk, Omar M., Chłosta, Piotr, Drewa, Tomasz   +3 more
openaire   +2 more sources