Results 41 to 50 of about 37,742 (258)

Associations of sarcopenia, sarcopenia components and sarcopenic obesity with cancer incidence: A prospective cohort study of 414,094 participants in UK Biobank

International Journal of Cancer, EarlyView.
What's New? Sarcopenia is highly prevalent and associated with adverse outcomes in cancer survivors. However, evidence regarding the role of sarcopenia in the general population as a potential risk factor for cancer development is scarce. This prospective cohort study investigated the association of sarcopenia with the incidence of 19 cancers in a ...
Panagiotis Filis, Christos K. Papagiannopoulos, Georgios Markozannes, Christos V. Chalitsios, Ioannis Zerdes, Antonios Valachis, Christopher Papandreou, Sofia Christakoudi, Konstantinos K. Tsilidis   +8 more
wiley   +1 more source

Prevalence of Hypogonadism and Associated Risk Factors among Newly Diagnosed ART Naïve HIV-Infected Males in Mwanza, Tanzania

International Journal of Endocrinology
Background. Hypogonadism is frequent among HIV-infected males and might have significant clinical impact leading to sexual impairment and metabolic derangement.
Shabani Iddi, Haruna Dika, Benson Kidenya, Samuel Kalluvya   +3 more
doaj   +1 more source

Systematic in‐hospital screening and treatment for osteoporosis in a geriatric population with hip fractures

Journal of Hospital Medicine, EarlyView.
Abstract Background Low‐trauma fractures of the hip signify osteoporosis and increase the risk of a second fracture. However, screening for secondary osteoporosis and initiating osteoporosis treatment can be challenging in a geriatric population.
Jeppe B. Rosenbæk, Line B. Dalgaard, Anne Grauballe, Stella J. Wilfred, Mikkel W. Ibsen, Lene R. Madsen   +5 more
wiley   +1 more source

Severe Obstructive Sleep Apnea After Pharyngeal Fat Injection for Velopharyngeal Insufficiency

The Laryngoscope, EarlyView.
ABSTRACT A 3‐month‐old male with a chromosomal deletion (8p11.23) underwent cleft lip and palate repair with a postoperative polysomnogram (PSG) showing mild obstructive sleep apnea. He underwent multiple surgical interventions for persistent sleep apnea in subsequent years with minimal improvement. Due to persistent hypernasality, he underwent harvest
Ruby Kazemi, Hannah Turbeville, David Zopf   +2 more
wiley   +1 more source

Association Between Type 2 Diabetes and Hypogonadism in India: An Observational Study

Indian Journal of Endocrinology and Metabolism
Introduction: Hypogonadism is a common comorbidity associated with several metabolic disorders including type 2 diabetes (T2D) that can remain undetected without proper screening.
Ambika G. Unnikrishnan, Banshi D. Saboo, Anirban Majumdar, Ravi K. Saraogi, Shanmuga Sundar, Shriraam Mahadevan, Anantharaman Ramakrishnan, Indraneel Basu, Deep Dutta, Arpan D. Bhattacharya, Prakadeesh Bharathi, Kalpesh Gawand   +11 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Adult-Onset Hypogonadism [PDF]

Mayo Clinic Proceedings, 2016
In August 2015, an expert colloquium commissioned by the Sexual Medicine Society of North America (SMSNA) convened in Washington, DC, to discuss the common clinical scenario of men who present with low testosterone (T) and associated signs and symptoms accompanied by low or normal gonadotropin levels.
Ravi Kacker, Lawrence S. Hakim, Ira D. Sharlip, Adrian S. Dobs, Culley C. Carson, Hossein Sadeghi-Nejad, Martha M. Faraday, Arthur L. Burnett, Irwin Goldstein, Gregory A. Broderick, Jesse N. Mills, Stephen J. Winters, Mohit Khera, Martin Miner, Martin Miner, Wayne J.G. Hellstrom, Wayne J.G. Hellstrom, Allen D. Seftel, Allen D. Seftel, Allen D. Seftel, Tobias S. Köhler   +20 more
openaire   +2 more sources

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Hypogonadism and associated factors among male Leprosy patients.

PLoS Neglected Tropical Diseases
BackgroundLeprosy affects various organs in addition to skin, eyes, and peripheral nerves. Testicular involvement in leprosy patients is common and causes disturbance in endocrine function of the testis and results in hypogonadism.
Nafyad Tolossa Urgie, Miftah Oumer Surur, Shimelis Nigussie, Beniam Worku Yigazu, Kidist Bobosha, Abebaye Aragaw, Getahun Shibru   +6 more
doaj   +1 more source

Rare Chromosomal Variants in Males with Hypogonadism: A Case Series From Tertiary Hospital in India

National Board of Examinations Journal of Medical Sciences
Male hypogonadism refers to decrease in testosterone levels due to diminished activity of testes. Hypogonadism will result in infertility, absent or poor secondary sexual characteristics and abnormal genitalia.
Anjali Shastry
doaj   +1 more source