Results 61 to 70 of about 72,413 (261)

Non-neural phenotype of spinal and bulbar muscular atrophy: Results from a large cohort of Italian patients [PDF]

, 2016
Objective: To carry out a deep characterisation of the main androgen-responsive tissues involved in spinal and bulbar muscular atrophy (SBMA). Methods: 73 consecutive Italian patients underwent a full clinical protocol including biochemical and hormonal ...
Angelini, Lorenzo, Bello, Luca, Bertolin, Cinzia, Briani, Chiara, Caretta, Nicola, Corrado, Domenico, da Re, Elisa, Ermani, Mario, Ferlin, Alberto, Foresta, Carlo, Gaiani, Alessandra, Galasso, Giuliana, Iafrate, Massimo, Mandrioli, Jessica, Mariotti, Caterina, Massa, Roberto, Mazzini, Letizia, Palmieri, Arianna, Pareyson, Davide, Pegoraro, Elena, Pennuto, Maria, Pennuto, Maria, Petrucci, Antonio, Polo, Alberto, Querin, Giorgia, Ricci, Giulia, Romito, Silvia, Sagnelli, Anna, Sartori, Leonardo, Scarpelli, Mauro, Semplicini, Claudio, Siciliano, Gabriele, Silani, Vincenzo, Silvano, Maria, Soraru', Gianni, Tonin, Paola, Volpe, Marco, Zara, Gabriella   +37 more
core   +1 more source

Long‐Term Outcomes of Deep Brain Stimulation in Woodhouse–Sakati Syndrome

Movement Disorders, EarlyView.
Abstract Background Woodhouse–Sakati syndrome (WSS) is a rare autosomal recessive disease with distinctive neuroendocrine manifestations, with dystonia being the most common. No clear guidelines are available for the treatment of dystonia in WSS. Objective The aim was to analyze the impact of deep brain stimulation (DBS) on WSS‐associated dystonia ...
Hend Alhodaif, Yara Alkhodair, Faisal Alotaibi, Salma Alqahtani, Saeed Bohlega, Amaal Aldakheel   +5 more
wiley   +1 more source

Testosterone deficiency increases hospital readmission and mortality rates in male patients with heart failure. [PDF]

, 2015
BackgroundTestosterone deficiency in patients with heart failure (HF) is associated with decreased exercise capacity and mortality; however, its impact on hospital readmission rate is uncertain.
Alves, Maria-Janieire de Nazaré Nunes, Arap, Marco Antônio, Barretto, Antônio Carlos Pereira, Fonseca, Guilherme, Groehs, Raphaela Vilar Ramalho, Middlekauff, Holly R, Negrão, Carlos Eduardo, Santos, Marcelo Rodrigues dos, Sayegh, Ana Luiza Carrari, Trombetta, Ivani Credidio   +9 more
core   +3 more sources

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Pancreas Cancer-Associated Weight Loss. [PDF]

, 2019
Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality.
Denlinger, Crystal S, Hendifar, Andrew E, Matrisian, Lynn M, Petzel, Maria QB, Picozzi, Vincent J, Precision Promise Consortium, Rahib, Lola, Zimmers, Teresa A   +7 more
core  

Assessing the utility of a natural language processing model in answering common urological questions

UroPrecision, EarlyView.
ABSTRACT Background ChatGPT, an interactive natural language processing model, is becoming increasingly used for medical information gathering. The objective of this study is to investigate the appropriateness of ChatGPT's responses to common urological questions compared to the Canadian Urological Association (CUA) guideline recommendations. Methods A
Wyatt MacNevin, John‐David Brown, Nicholas Dawe, Jesse T. R. Spooner, Nicholas R. Paterson, Daniel T. Keefe, David G. Bell   +6 more
wiley   +1 more source

Hypogonadism and associated factors among male Leprosy patients.

PLoS Neglected Tropical Diseases
BackgroundLeprosy affects various organs in addition to skin, eyes, and peripheral nerves. Testicular involvement in leprosy patients is common and causes disturbance in endocrine function of the testis and results in hypogonadism.
Nafyad Tolossa Urgie, Miftah Oumer Surur, Shimelis Nigussie, Beniam Worku Yigazu, Kidist Bobosha, Abebaye Aragaw, Getahun Shibru   +6 more
doaj   +1 more source

Association Between Type 2 Diabetes and Hypogonadism in India: An Observational Study

Indian Journal of Endocrinology and Metabolism
Introduction: Hypogonadism is a common comorbidity associated with several metabolic disorders including type 2 diabetes (T2D) that can remain undetected without proper screening.
Ambika G. Unnikrishnan, Banshi D. Saboo, Anirban Majumdar, Ravi K. Saraogi, Shanmuga Sundar, Shriraam Mahadevan, Anantharaman Ramakrishnan, Indraneel Basu, Deep Dutta, Arpan D. Bhattacharya, Prakadeesh Bharathi, Kalpesh Gawand   +11 more
doaj   +1 more source

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland, Henze, R., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +4 more
core   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source