Results 21 to 30 of about 10,287 (203)

PCSK9 Antagonists: Clinical Efficacy and Main Trends in the Development of New Medicines

Безопасность и риск фармакотерапии, 2023
Scientific relevance. Cardiovascular diseases (CVD) are the leading cause of death worldwide. Dyslipidemia, as the pathophysiological basis of atherosclerosis, is the most important cause of CVD.
A. A. Nekipelova, R. N. Alyautdin
doaj   +1 more source

Studies on hypolipidemic agents. IV. Influence of a new hypolipidemic agent, 5-tridecylpyrazole-3-carboxylic acid, on cholesterol metabolism in rats.

Chemical and Pharmaceutical Bulletin, 1985
KUNIO SEKI, Minoru Fukuda, M. OHKI
openalex   +5 more sources

Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives

Molecules, 2022
Novel pyrrolo [2,3-b] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the new derivatives were confirmed through spectral analysis.
Moumen S. Kamel, Amany Belal, Moustafa O. Aboelez, E. Kh. Shokr, H. Abdel-Ghany, Hany S. Mansour, Ahmed M. Shawky, Mahmoud Abd El Aleem Ali Ali El-Remaily   +7 more
doaj   +1 more source

Sustainable Synthesis of the Naturally Hypolipidemic Agent α-Asarone [PDF]

Synthetic Communications, 2015
:A short and practical preparation of α-asarone was developed using the inexpensive methylisoeugenol as a starting material. The utilization of a sequence of tribromination, debromination and copper-mediated aromatic substitution enabled the stereoselective formation of only the E isomer of α-asarone in good yield.
Alejandro Camacho-Dávila, Gerardo Zaragoza-Galán, David Chávez-Flores, Víctor H. Ramos-Sánchez   +3 more
openaire   +2 more sources

The Use of Primary Care Electronic Health Records for Research: Lipid Medications and Mortality in Elderly Patients

Pharmacy, 2019
General practice electronic health record (EHR) data have significant potential for clinical research. This study demonstrates the feasibility of utilising longitudinal EHR data analysis to address clinically relevant outcomes and uses the relationship ...
Adam J. Hodgkins, Judy Mullan, Darren J. Mayne, Andrew Bonney   +3 more
doaj   +1 more source

MODELING OF MICE AS TEST ANIMALS FOR A PRECLINICAL STUDY OF HYPOLIPIDEMIC AGENTS

Jurnal Farmasi Sains dan Praktis, 2023
Animal models suitable for preclinical research are necessary for the discovery of hypolipidemic agents. Various publications have presented alternative dyslipidemia animal models, but identifying a feasible and stable method would serve as a solid ...
Setiyo Budi Santoso, Widarika Santi Hapsari, Renny Setyowati   +2 more
doaj   +1 more source

Study on the influence of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives on the lipid metabolism in experiment

Zaporožskij Medicinskij Žurnal, 2021
Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents.
I. M. Bilai, M. I. Romanenko, D. H. Ivanchenko   +2 more
doaj   +1 more source

Comparative analysis of the use of lipid modifying agents in the Republic of Serbia and Nordic countries in the period 2015-2017 [PDF]

Hospital Pharmacology, 2020
Introduction: Cardiovascular diseases are the leading cause of death both in Serbia and in the rest of the world. It has been shown that as many as 80% of them are preventable.
Martić Nikola B., Zečević Dragan D., Đurđević Milena V., Milijašević Dragana S., Tomić Nataša Z., Lalić-Popović Mladena N., Todorović Nemanja B., Medin Danilo V., Mićanović Branimir B., Milijašević Boris Ž.   +9 more
doaj  

Lipid-lowering drug prescriptions in a group of Colombian patients

Biomédica: revista del Instituto Nacional de Salud, 2019
Introduction. Lipid-lowering drugs, especially statins, have shown great relevance in preventing and treating cardiovascular diseases. Objective. To determine the prescription patterns of lipid-lowering drugs and the variables associated with their use ...
Andres Gaviria-Mendoza, Manuel E. Machado-Duque, Jorge E. Machado-Alba   +2 more
doaj   +1 more source

Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis

Annals of Medicine, 2022
Atherosclerotic heart disease is the leading cause of mortality and morbidity in the USA. Low density lipoprotein (LDL) has been the target for many hypolipidemic agents to modify atherosclerotic risk.
Ramyashree Tummala, Manasvi Gupta, Arvind Reddy Devanabanda, Dhrubajyoti Bandyopadhyay, Wilbert S. Aronow, Kausik K. Ray, Mamas Mamas, Raktim K. Ghosh   +7 more
doaj   +1 more source