Results 11 to 20 of about 43,375 (245)

Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome

eLife, 2020
Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based on whole ...
Jeanne L Theis, Georg Vogler, Maria A Missinato, Xing Li, Tanja Nielsen, Xin-Xin I Zeng, Almudena Martinez-Fernandez, Stanley M Walls, Anaïs Kervadec, James N Kezos, Katja Birker, Jared M Evans, Megan M O'Byrne, Zachary C Fogarty, André Terzic, Paul Grossfeld, Karen Ocorr, Timothy J Nelson, Timothy M Olson, Alexandre R Colas, Rolf Bodmer   +20 more
doaj   +2 more sources

Hypoplastic left heart syndrome – Unresolved Issues [PDF]

Frontiers in Pediatrics, 2014
Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present it is expected that - at best - 70% of newborns with HLHA will reach adulthood. This review addresses the problems of right ventricular failure and
Raoul Roman Arnold, Tsvetomir eLoukanov, Matthias eGorenflo   +2 more
doaj   +4 more sources

A rare case of hypoplastic left heart syndrome in pregnancy and its outcome [PDF]

New Indian Journal of OBGYN, 2022
Hypoplastic left heart syndrome is abnormal development of left sided cardiac structure, leading to obstruction to blood flow from the left ventricular outflow tract.
Akshatha DS, Shakuntala PN, Sreelatha S, Sumayya, Shruthi   +4 more
doaj   +1 more source

Transcriptome studies of congenital heart diseases: identifying current gaps and therapeutic frontiers

Frontiers in Genetics, 2023
Congenital heart disease (CHD) are genetically complex and comprise a wide range of structural defects that often predispose to - early heart failure, a common cause of neonatal morbidity and mortality.
Nkechi Martina Odogwu, Clinton Hagen, Timothy J. Nelson, Timothy J. Nelson, Timothy J. Nelson, Timothy J. Nelson, Timothy J. Nelson   +6 more
doaj   +1 more source

Prenatal diagnosis of hypoplastic left heart syndrome on ultrasound using artificial intelligence: How does performance compare to a current screening programme?

Prenatal Diagnosis, 2023
Artificial intelligence (AI) has the potential to improve prenatal detection of congenital heart disease. We analysed the performance of the current national screening programme in detecting hypoplastic left heart syndrome (HLHS) to compare with our own ...
T. Day, Samuel Budd, Jeremy Tan, J. Matthew, E. Skelton, V. Jowett, D. Lloyd, Alberto Gómez, J. Hajnal, Reza Razavi, Bernhard Kainz, J. Simpson   +11 more
semanticscholar   +1 more source

Hypoplastic Left Heart Syndrome [PDF]

RadioGraphics, 2001
Hypoplastic left heart syndrome (HLHS) is a complex combination of cardiac malformations that probably results from multiple developmental errors in the early stages of cardiogenesis and that, if left untreated, invariably proves fatal. A variety of chest radiographic findings are seen in patients with HLHS, including an enlarged cardiac silhouette ...
Kimberly E. Applegate, Daniel J. Murphy, David G. Frankel, Russel P. Saneto, Dianna M. E. Bardo   +4 more
openaire   +6 more sources

Impact of Socioeconomic Status, Race and Ethnicity, and Geography on Prenatal Detection of Hypoplastic Left Heart Syndrome and Transposition of the Great Arteries

Circulation, 2021
Background: Prenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic and geographic factors with PND have not been sufficiently ...
A. Krishnan, Marni B. Jacobs, S. Morris, S. Peyvandi, A. Bhat, Anjali Chelliah, J. Chiu, B. Cuneo, G. Freire, L. Hornberger, L. Howley, N. Husain, Catherine M. Ikemba, A. Kavanaugh-McHugh, S. Kutty, Caroline K. Lee, Keila N. Lopez, A. McBrien, E. Michelfelder, N. Pinto, Rachel Schwartz, K. Stern, Carolyn L. Taylor, V. Thakur, W. Tworetzky, Carol A. Wittlieb-Weber, K. Woldu, M. Donofrio   +27 more
semanticscholar   +1 more source

Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases

Journal of Cardiovascular Development and Disease, 2022
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with complex genetic inheritance. HLHS segregates with other left ventricular outflow tract (LVOT) malformations in families, and can present as either an isolated ...
Melissa Anfinson, R. Fitts, J. Lough, Jeanne M. James, P. Simpson, Stephanie S. Handler, Michael E. Mitchell, A. Tomita‐Mitchell   +7 more
semanticscholar   +1 more source

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

bioRxiv, 2021
Background Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular outflow tract obstruction defects ...
M. Krane, M. Dreßen, Gianluca Santamaria, Ilaria My, C. Schneider, Tatjana Dorn, S. Laue, E. Mastantuono, Riccardo Berutti, Hilansi Rawat, R. Gilsbach, P. Schneider, H. Lahm, S. Schwarz, S. Doppler, Sharon L. Paige, N. Puluca, S. Doll, I. Neb, Thomas Brade, Zhong Zhang, C. Abou‐Ajram, B. Northoff, L. Holdt, S. Sudhop, Makoto Sahara, A. Goedel, A. Dendorfer, F. Tjong, M. Rijlaarsdam, J. Cleuziou, N. Lang, C. Kupatt, C. Bezzina, R. Lange, N. Bowles, M. Mann, B. Gelb, L. Crotti, L. Hein, T. Meitinger, Sean M. Wu, D. Sinnecker, P. Gruber, K. Laugwitz, A. Moretti   +45 more
semanticscholar   +1 more source

Use of Frogs as a Model to Study the Etiology of HLHS

Journal of Cardiovascular Development and Disease, 2023
A frog is a classical model organism used to uncover processes and regulations of early vertebrate development, including heart development. Recently, we showed that a frog also represents a useful model to study a rare human congenital heart disease ...
Shuyi Nie
doaj   +1 more source