Results 21 to 30 of about 59,480 (283)

Hypoplastic Left Heart Syndrome [PDF]

RadioGraphics, 2001
Hypoplastic left heart syndrome (HLHS) is a complex combination of cardiac malformations that probably results from multiple developmental errors in the early stages of cardiogenesis and that, if left untreated, invariably proves fatal. A variety of chest radiographic findings are seen in patients with HLHS, including an enlarged cardiac silhouette ...
D M, Bardo, D G, Frankel, K E, Applegate, D J, Murphy, R P, Saneto   +4 more
openaire   +4 more sources

Transcriptome studies of congenital heart diseases: identifying current gaps and therapeutic frontiers

Frontiers in Genetics, 2023
Congenital heart disease (CHD) are genetically complex and comprise a wide range of structural defects that often predispose to - early heart failure, a common cause of neonatal morbidity and mortality.
Nkechi Martina Odogwu, Clinton Hagen, Timothy J. Nelson, Timothy J. Nelson, Timothy J. Nelson, Timothy J. Nelson, Timothy J. Nelson   +6 more
doaj   +1 more source

Prenatal diagnosis of hypoplastic left heart syndrome on ultrasound using artificial intelligence: How does performance compare to a current screening programme?

Prenatal Diagnosis, 2023
Artificial intelligence (AI) has the potential to improve prenatal detection of congenital heart disease. We analysed the performance of the current national screening programme in detecting hypoplastic left heart syndrome (HLHS) to compare with our own ...
T. Day, Samuel Budd, Jeremy Tan, J. Matthew, E. Skelton, V. Jowett, D. Lloyd, Alberto Gómez, J. Hajnal, Reza Razavi, Bernhard Kainz, J. Simpson   +11 more
semanticscholar   +1 more source

Impact of Socioeconomic Status, Race and Ethnicity, and Geography on Prenatal Detection of Hypoplastic Left Heart Syndrome and Transposition of the Great Arteries

Circulation, 2021
Background: Prenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic and geographic factors with PND have not been sufficiently ...
A. Krishnan, Marni B. Jacobs, S. Morris, S. Peyvandi, A. Bhat, Anjali Chelliah, J. Chiu, B. Cuneo, G. Freire, L. Hornberger, L. Howley, N. Husain, Catherine M. Ikemba, A. Kavanaugh-McHugh, S. Kutty, Caroline K. Lee, Keila N. Lopez, A. McBrien, E. Michelfelder, N. Pinto, Rachel Schwartz, K. Stern, Carolyn L. Taylor, V. Thakur, W. Tworetzky, Carol A. Wittlieb-Weber, K. Woldu, M. Donofrio   +27 more
semanticscholar   +1 more source

Hypoplastic Left Heart Syndrome: A Case Report

Journal of Nepal Medical Association, 2023
Hypoplastic left heart syndrome is a rare critical congenital heart defect constituting a prevalence of 1/3,500 to 1/12,500 live births in which there is obstructions to the blood flow within the left heart.
Sunil Raja Manandhar, Anjila Ghimire, Dipendra Rai, Sabina Shrestha, Pritha Adhikari   +4 more
doaj   +1 more source

Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases

Journal of Cardiovascular Development and Disease, 2022
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with complex genetic inheritance. HLHS segregates with other left ventricular outflow tract (LVOT) malformations in families, and can present as either an isolated ...
Melissa Anfinson, R. Fitts, J. Lough, Jeanne M. James, P. Simpson, Stephanie S. Handler, Michael E. Mitchell, A. Tomita‐Mitchell   +7 more
semanticscholar   +1 more source

Use of Frogs as a Model to Study the Etiology of HLHS

Journal of Cardiovascular Development and Disease, 2023
A frog is a classical model organism used to uncover processes and regulations of early vertebrate development, including heart development. Recently, we showed that a frog also represents a useful model to study a rare human congenital heart disease ...
Shuyi Nie
doaj   +1 more source

Current state of the art in hypoplastic left heart syndrome

Frontiers in Cardiovascular Medicine, 2022
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart condition in which a neonate is born with an underdeveloped left ventricle and associated structures. Without palliative interventions, HLHS is fatal.
Aditya K. Birla, Sunita Brimmer, W. D. Short, O. Olutoye, Jason A. Shar, Suriya Lalwani, P. Sucosky, A. Parthiban, S. Keswani, C. Caldarone, R. Birla   +10 more
semanticscholar   +1 more source

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

bioRxiv, 2021
Background Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular outflow tract obstruction defects ...
M. Krane, M. Dreßen, Gianluca Santamaria, Ilaria My, C. Schneider, Tatjana Dorn, S. Laue, E. Mastantuono, Riccardo Berutti, Hilansi Rawat, R. Gilsbach, P. Schneider, H. Lahm, S. Schwarz, S. Doppler, Sharon L. Paige, N. Puluca, S. Doll, I. Neb, Thomas Brade, Zhong Zhang, C. Abou‐Ajram, B. Northoff, L. Holdt, S. Sudhop, Makoto Sahara, A. Goedel, A. Dendorfer, F. Tjong, M. Rijlaarsdam, J. Cleuziou, N. Lang, C. Kupatt, C. Bezzina, R. Lange, N. Bowles, M. Mann, B. Gelb, L. Crotti, L. Hein, T. Meitinger, Sean M. Wu, D. Sinnecker, P. Gruber, K. Laugwitz, A. Moretti   +45 more
semanticscholar   +1 more source

Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome

Biomechanics and Modeling in Mechanobiology, 2021
Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation.
H. E. Salman, Maha Alser, Akshay Shekhar, Russell A. Gould, F. Benslimane, J. Butcher, H. Yalcin   +6 more
semanticscholar   +1 more source