Results 11 to 20 of about 59,480 (283)
Hypoplastic left heart syndrome [PDF]
Orphanet Journal of Rare Diseases, 2007 Hypoplastic left heart syndrome(HLHS) refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left
Thiagarajan Ravi, Connor Jean
doaj +4 more sources
What Is the Hypoplastic Left Heart Syndrome?
Journal of Cardiovascular Development and Disease, 2023 As yet, there is no agreed definition for the so-called “hypoplastic left heart syndrome”. Even its origin remains contentious. Noonan and Nadas, who as far as we can establish first grouped together patients as belonging to a “syndrome” in 1958 ...
Robert H. Anderson +2 more
doaj +2 more sources
Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome
Cell Stem Cell, 2020 Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized by abnormalities in the left ventricle, associated valves, and ascending aorta.
Yifei Miao, Lei Tian, Marcella Martin
exaly +2 more sources
Hypoplastic left heart syndrome: a review [PDF]
Acta Medica Lituanica, 2016 Background. Hypoplastic left heart syndrome (HLHS) is an etiologically multifactorial congenital heart disease affecting one in 5,000 newborns. Thirty years ago there were no treatment options for this pathology and the natural course of the disease ...
Roberts Gobergs +2 more
doaj +3 more sources
Nature Communications, 2022 The developmental mechanisms responsible for the structural defects observed in hypoplastic left heart syndrome remain controversial. Using rbfox-deficient zebrafish, the authors implicate impaired cardiac function as a primary driver of disease.
Mengmeng Huang +10 more
doaj +2 more sources
Hypoplastic left heart syndrome – Unresolved Issues [PDF]
Frontiers in Pediatrics, 2014 Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present it is expected that - at best - 70% of newborns with HLHA will reach adulthood. This review addresses the problems of right ventricular failure and
Raoul Roman Arnold +2 more
doaj +3 more sources
Hypoplastic Left Heart Syndrome: Is There a Role for Fetal Therapy?
Frontiers in Pediatrics, 2022 During fetal life some cardiac defects may lead to diminished left heart growth and to the evolution of a form of hypoplastic left heart syndrome (HLHS).
Andreas Tulzer +7 more
doaj +3 more sources
eLife, 2020 Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based on whole ...
Jeanne L Theis +20 more
doaj +2 more sources
Hypoplastic left heart syndrome with mitral regurgitation: a new marker of poor fetal outcome [PDF]
Journal of UltrasonographyHypoplastic left heart syndrome is a severe congenital heart defect that may be accompanied by tricuspid and mitral valve regurgitation. The aim of this paper is to identify a new ultrasound marker for evaluating the outcomes of fetuses with hypoplastic ...
Witkowski Sławomir +2 more
doaj +2 more sources
A rare case of hypoplastic left heart syndrome in pregnancy and its outcome [PDF]
New Indian Journal of OBGYN, 2022 Hypoplastic left heart syndrome is abnormal development of left sided cardiac structure, leading to obstruction to blood flow from the left ventricular outflow tract.
Akshatha DS +4 more
doaj +1 more source