Results 21 to 30 of about 43,375 (245)

Current state of the art in hypoplastic left heart syndrome

Frontiers in Cardiovascular Medicine, 2022
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart condition in which a neonate is born with an underdeveloped left ventricle and associated structures. Without palliative interventions, HLHS is fatal.
Aditya K. Birla, Sunita Brimmer, W. D. Short, O. Olutoye, Jason A. Shar, Suriya Lalwani, P. Sucosky, A. Parthiban, S. Keswani, C. Caldarone, R. Birla   +10 more
semanticscholar   +1 more source

Flow-Mediated Factors in the Pathogenesis of Hypoplastic Left Heart Syndrome

Journal of Cardiovascular Development and Disease, 2022
Hypoplastic left heart syndrome (HLHS) is a life-threatening congenital heart disease that is characterized by severe underdevelopment of left heart structures.
Anum Rahman, R. Chaturvedi, J. Sled
semanticscholar   +1 more source

Serial Assessment of Right Ventricular Deformation in Patients With Hypoplastic Left Heart Syndrome: A Cardiovascular Magnetic Resonance Feature Tracking Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2022
Background As right ventricular dysfunction is a major cause of adverse outcome in patients with hypoplastic left heart syndrome, the aim was to assess right ventricular function and deformation after Fontan completion by performing 2‐dimensional ...
L. M. Kanngiesser, S. Freitag-Wolf, Simona Boroni Grazioli, D. Gabbert, J. Hansen, A. Uebing, I. Voges   +6 more
semanticscholar   +1 more source

Hypoplastic Left Heart Syndrome: Is There a Role for Fetal Therapy?

Frontiers in Pediatrics, 2022
During fetal life some cardiac defects may lead to diminished left heart growth and to the evolution of a form of hypoplastic left heart syndrome (HLHS).
Andreas Tulzer, Andreas Tulzer, James C. Huhta, Julian Hochpoechler, Kathrin Holzer, Thomas Karas, David Kielmayer, Gerald Tulzer   +7 more
doaj   +1 more source

Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome

Biomechanics and Modeling in Mechanobiology, 2021
Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation.
H. E. Salman, Maha Alser, Akshay Shekhar, Russell A. Gould, F. Benslimane, J. Butcher, H. Yalcin   +6 more
semanticscholar   +1 more source

A mouse model of hypoplastic left heart syndrome demonstrating left heart hypoplasia and retrograde aortic arch flow

Disease Models & Mechanisms, 2021
In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia and their associated fetal abnormalities are largely unknown.
Anum Rahman, Taylor DeYoung, L. Cahill, Yohan Yee, Sarah K Debebe, O. Botelho, M. Seed, R. Chaturvedi, J. Sled   +8 more
semanticscholar   +1 more source

The Left Ventricular Myocardium in Hypoplastic Left Heart Syndrome

Journal of Cardiovascular Development and Disease, 2022
Hypoplastic left heart syndrome (HLHS) is a collective term applied to severe congenital cardiac malformations, characterised by a combination of abnormalities mainly affecting the left ventricle, associated valves, and ascending aorta.
Bill Chaudhry, Ahlam Alqahtani, Lorraine Eley, Louise Coats, Corina Moldovan, Srinivas R. Annavarapu, Deborah J. Henderson   +6 more
doaj   +1 more source

Myocardial Perfusion in Hypoplastic Left Heart Syndrome

Circulation Cardiovascular Imaging, 2021
Supplemental Digital Content is available in the text. Background: The status of the systemic right ventricular coronary microcirculation in hypoplastic left heart syndrome (HLHS) is largely unknown.
C. Rickers, P. Wegner, M. Silberbach, Erin Madriago, D. Gabbert, A. Kheradvar, I. Voges, J. Scheewe, T. Attmann, M. Jerosch-Herold, Hans-Heiner Kramer   +10 more
semanticscholar   +1 more source

Impact of Left Ventricular Morphology on Adverse Outcomes Following Stage 1 Palliation for Hypoplastic Left Heart Syndrome: 20 Years of National Data From Sweden

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Hypoplastic left heart syndrome is associated with significant morbidity and mortality. We aimed to assess the influence of left ventricular morphology and choice of shunt on adverse outcome in patients with hypoplastic left heart syndrome and
Katrin Fricke, Mats Mellander, Katarina Hanséus, Phan‐Kiet Tran, Mats Synnergren, Jens Johansson Ramgren, Annika Rydberg, Jan Sunnegårdh, Magnus Dalén, Gunnar Sjöberg, Constance G. Weismann, Petru Liuba,   +11 more
doaj   +1 more source

Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling

Communications Biology, 2023
Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth failure, we generate left ventricular inflow obstruction (LVIO ...
Miriam S. Reuter, Dustin J. Sokolowski, J. Javier Diaz-Mejia, Johannes Keunen, Barbra de Vrijer, Cadia Chan, Liangxi Wang, Greg Ryan, David A. Chiasson, Troy Ketela, Stephen W. Scherer, Michael D. Wilson, Edgar Jaeggi, Rajiv R. Chaturvedi   +13 more
doaj   +1 more source