Results 21 to 30 of about 1,584 (188)

Hypoprothrombinemia: case report [PDF]

Blood, 1978
A patient with a significant history of spontaneous and posttraumatic bleeding was found to have hypoprothrombinemia. His prothrombin (factor II) activity by clotting assay was 9.5% and his factor II antigen was 5%. Crossed immunoelectrophoresis and sucrose density gradient ultracentrifugation of the patient's plasma showed his prothrombin to be ...
William E. Hathaway, Robert R. Montgomery, A Otsuka   +2 more
openaire   +4 more sources

Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation

Clinical Case Reports, Volume 11, Issue 6, June 2023., 2023
Key Clinical Message Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment.
Marlena Frydrysiak, Paulina Pachniak, Anna Krysicka, Dariusz Moczulski   +3 more
wiley   +1 more source

Clinical features and treatment of 70 child with lupus anticoagulant-hypoprothrombinemia syndrome: A retrospective study from a single centre in China

Research and Practice in Thrombosis and Haemostasis
Dandan Tian, Junfeng Zhang, Jintu Lou, Xuejun Chen, Juan Liang, Xiaojun Xu, Hui Gao, Wenjian Nie, Qing Ye, Hongqiang Shen   +9 more
openalex   +2 more sources

A suspicious case of cefmetazole‐induced hypoprothrombinemia

Journal of General and Family Medicine, Volume 18, Issue 5, Page 258-260, October 2017., 2017
Abstract Cefmetazole occasionally prolongs the prothrombin time. The mechanism is considered to be because of (i) inhibition of vitamin K metabolism, (ii) a lack of vitamin K, and (iii) low vitamin K stores. We report the death of a 93‐year‐old woman who was administered cefmetazole and exhibited a prolonged prothrombin time.
Nobuhiro Kodama, Shuichi Matsumoto, Sunao Matsubayashi   +2 more
openalex   +2 more sources

Neuropsychiatric Lupus and Lupus Nephritis Successfully Treated with Combined IVIG and Rituximab: An Alternative to Standard of Care

Case Reports in Rheumatology, Volume 2022, Issue 1, 2022., 2022
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unpredictable course and flares. The clinical manifestation can vary from mild to severe and life‐threatening disease. Infection is the primary cause of mortality in hospitalized SLE patients.
Mohamed M. Cheikh, Abdullah K. Bahakim, Moayad K. Aljabri, Saad M. Alharthi, Sanad M. Alharthi, Abdullah K. Alsaeedi, Saad F. Alqahtani, Constantine Saadeh   +7 more
wiley   +1 more source

A case of congenital prothrombin deficiency with two concurrent mutations in the prothrombin gene

Research and Practice in Thrombosis and Haemostasis, Volume 5, Issue 4, May 2021., 2021
Abstract Congenital prothrombin deficiency is an extremely rare, autosomal recessive bleeding disorder with a prevalence of 1 in 2 million individuals. Here, we report a case of congenital prothrombin deficiency with two concurrent mutations in the prothrombin gene (F2), affecting the heavy B chain.
Eman M. Mansory, Pratibha Bhai, Alan Stuart, Lori Laudenbach, Bekim Sadikovic, Alejandro Lazo‐Langner   +5 more
wiley   +1 more source

Monitoring of anticoagulation in thrombotic antiphospholipid syndrome

Journal of Thrombosis and Haemostasis, Volume 19, Issue 4, Page 892-908, April 2021., 2021
Abstract Anticoagulation is central to the management of thrombotic antiphospholipid syndrome (APS). The standard anticoagulant treatment for thrombotic APS is life‐long warfarin or an alternative vitamin K antagonist. The role of direct oral anticoagulants for thrombotic APS is not established due to the lack of definitive evidence and has recently ...
Hannah Cohen, Maria Efthymiou, Katrien M. J. Devreese   +2 more
wiley   +1 more source

A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome [PDF]

Blood, 1983
Antibodies that bind prothrombin without neutralizing its coagulant activity were demonstrated in the plasma of two patients with the acquired hypoprothrombinemia-lupus anticoagulant syndrome. The first patient's plasma contained less than 1% prothrombin activity and no detectable prothrombin antigen.
SI Rapaport, Daniel S. Fierer, KD Herbst, SP Bajaj, DB Schwartz   +4 more
openaire   +4 more sources

Hypoprothrombinemia Induced by Gossypol.

Experimental Biology and Medicine, 1951
SummaryGossypol induces hypoprothrombinemia in rabbits and pigs. Cottonseed meal containing free gossypol induces hypoprothrombinemia in young rabbits which begins after about 7 days feeding and passes through a maximum at approximately 17 days then slowly returns tto normal around 28 days. Gossypol is not as effective an anticoagulant as Dicumarol but
W. S. Harms, K. T. Holley
openaire   +3 more sources

Pathophysiology of coronavirus disease 2019 for wound care professionals

International Wound Journal, Volume 17, Issue 6, Page 1935-1940, December 2020., 2020
Abstract There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) which causes Coronavirus disease 2019 (COVID‐19). The tissue tropism of SARS‐CoV‐2 includes not only the lung but also the vascular and integumentary systems.
Sammy Al‐Benna
wiley   +1 more source